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Gene: COMMD8 |
Gene summary for COMMD8 |
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Gene information | Species | Human | Gene symbol | COMMD8 | Gene ID | 54951 |
Gene name | COMM domain containing 8 | |
Gene Alias | COMMD8 | |
Cytomap | 4p12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NX08 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54951 | COMMD8 | LZE4T | Human | Esophagus | ESCC | 5.32e-14 | 4.10e-01 | 0.0811 |
54951 | COMMD8 | LZE7T | Human | Esophagus | ESCC | 2.24e-04 | 3.43e-01 | 0.0667 |
54951 | COMMD8 | LZE8T | Human | Esophagus | ESCC | 9.47e-04 | 2.65e-01 | 0.067 |
54951 | COMMD8 | LZE20T | Human | Esophagus | ESCC | 2.41e-10 | 2.30e-01 | 0.0662 |
54951 | COMMD8 | LZE24T | Human | Esophagus | ESCC | 8.59e-15 | 3.66e-01 | 0.0596 |
54951 | COMMD8 | LZE6T | Human | Esophagus | ESCC | 1.12e-11 | 7.01e-01 | 0.0845 |
54951 | COMMD8 | P2T-E | Human | Esophagus | ESCC | 1.18e-27 | 5.64e-01 | 0.1177 |
54951 | COMMD8 | P4T-E | Human | Esophagus | ESCC | 9.36e-39 | 9.09e-01 | 0.1323 |
54951 | COMMD8 | P5T-E | Human | Esophagus | ESCC | 8.72e-15 | 3.39e-01 | 0.1327 |
54951 | COMMD8 | P8T-E | Human | Esophagus | ESCC | 4.54e-24 | 5.06e-01 | 0.0889 |
54951 | COMMD8 | P9T-E | Human | Esophagus | ESCC | 8.70e-11 | 2.36e-01 | 0.1131 |
54951 | COMMD8 | P10T-E | Human | Esophagus | ESCC | 1.76e-21 | 3.81e-01 | 0.116 |
54951 | COMMD8 | P11T-E | Human | Esophagus | ESCC | 2.43e-15 | 6.54e-01 | 0.1426 |
54951 | COMMD8 | P12T-E | Human | Esophagus | ESCC | 3.55e-21 | 4.44e-01 | 0.1122 |
54951 | COMMD8 | P15T-E | Human | Esophagus | ESCC | 1.33e-21 | 6.57e-01 | 0.1149 |
54951 | COMMD8 | P16T-E | Human | Esophagus | ESCC | 1.03e-18 | 3.46e-01 | 0.1153 |
54951 | COMMD8 | P20T-E | Human | Esophagus | ESCC | 5.20e-16 | 2.80e-01 | 0.1124 |
54951 | COMMD8 | P21T-E | Human | Esophagus | ESCC | 1.06e-33 | 7.43e-01 | 0.1617 |
54951 | COMMD8 | P22T-E | Human | Esophagus | ESCC | 4.74e-19 | 3.10e-01 | 0.1236 |
54951 | COMMD8 | P23T-E | Human | Esophagus | ESCC | 2.59e-07 | 3.09e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COMMD8 | SNV | Missense_Mutation | novel | c.371N>G | p.Val124Gly | p.V124G | Q9NX08 | protein_coding | deleterious(0) | benign(0.376) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COMMD8 | SNV | Missense_Mutation | novel | c.371N>G | p.Val124Gly | p.V124G | Q9NX08 | protein_coding | deleterious(0) | benign(0.376) | TCGA-E9-A1NF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
COMMD8 | SNV | Missense_Mutation | novel | c.440N>G | p.Val147Gly | p.V147G | Q9NX08 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
COMMD8 | SNV | Missense_Mutation | c.179A>C | p.Lys60Thr | p.K60T | Q9NX08 | protein_coding | tolerated(0.99) | benign(0) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
COMMD8 | SNV | Missense_Mutation | c.143C>T | p.Ser48Leu | p.S48L | Q9NX08 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
COMMD8 | SNV | Missense_Mutation | c.101N>A | p.Arg34Gln | p.R34Q | Q9NX08 | protein_coding | tolerated(0.2) | possibly_damaging(0.86) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
COMMD8 | SNV | Missense_Mutation | c.227N>G | p.Phe76Cys | p.F76C | Q9NX08 | protein_coding | tolerated(0.13) | benign(0.183) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
COMMD8 | SNV | Missense_Mutation | novel | c.531N>T | p.Lys177Asn | p.K177N | Q9NX08 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COMMD8 | SNV | Missense_Mutation | novel | c.79N>G | p.Ile27Val | p.I27V | Q9NX08 | protein_coding | tolerated(1) | benign(0.006) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
COMMD8 | SNV | Missense_Mutation | novel | c.121N>T | p.Asp41Tyr | p.D41Y | Q9NX08 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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