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Gene: COMMD4 |
Gene summary for COMMD4 |
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Gene information | Species | Human | Gene symbol | COMMD4 | Gene ID | 54939 |
Gene name | COMM domain containing 4 | |
Gene Alias | COMMD4 | |
Cytomap | 15q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H0A8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54939 | COMMD4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.75e-03 | 2.63e-01 | -0.1808 |
54939 | COMMD4 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.76e-03 | 1.92e-01 | -0.1954 |
54939 | COMMD4 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.29e-02 | 5.70e-01 | -0.2602 |
54939 | COMMD4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 8.66e-03 | 3.28e-01 | -0.1207 |
54939 | COMMD4 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.78e-08 | 2.76e-01 | -0.1464 |
54939 | COMMD4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.86e-06 | 3.43e-01 | -0.059 |
54939 | COMMD4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.06e-03 | 2.02e-01 | 0.294 |
54939 | COMMD4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.97e-02 | 1.41e-01 | 0.3005 |
54939 | COMMD4 | LZE2T | Human | Esophagus | ESCC | 7.08e-04 | 8.55e-01 | 0.082 |
54939 | COMMD4 | LZE4T | Human | Esophagus | ESCC | 5.91e-12 | 3.96e-01 | 0.0811 |
54939 | COMMD4 | LZE7T | Human | Esophagus | ESCC | 3.18e-21 | 1.08e+00 | 0.0667 |
54939 | COMMD4 | LZE8T | Human | Esophagus | ESCC | 7.09e-09 | 2.66e-01 | 0.067 |
54939 | COMMD4 | LZE20T | Human | Esophagus | ESCC | 1.64e-06 | 1.82e-01 | 0.0662 |
54939 | COMMD4 | LZE22D1 | Human | Esophagus | HGIN | 1.70e-02 | 1.64e-01 | 0.0595 |
54939 | COMMD4 | LZE22T | Human | Esophagus | ESCC | 7.69e-06 | 4.98e-01 | 0.068 |
54939 | COMMD4 | LZE24T | Human | Esophagus | ESCC | 5.02e-16 | 4.13e-01 | 0.0596 |
54939 | COMMD4 | LZE22D3 | Human | Esophagus | HGIN | 2.71e-02 | 4.75e-01 | 0.0653 |
54939 | COMMD4 | LZE21T | Human | Esophagus | ESCC | 6.13e-12 | 7.74e-01 | 0.0655 |
54939 | COMMD4 | LZE6T | Human | Esophagus | ESCC | 1.24e-10 | 7.15e-01 | 0.0845 |
54939 | COMMD4 | P1T-E | Human | Esophagus | ESCC | 2.55e-24 | 1.03e+00 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COMMD4 | SNV | Missense_Mutation | c.490G>A | p.Ala164Thr | p.A164T | Q9H0A8 | protein_coding | tolerated(0.3) | benign(0.006) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | ||
COMMD4 | SNV | Missense_Mutation | novel | c.196A>G | p.Lys66Glu | p.K66E | Q9H0A8 | protein_coding | deleterious(0.04) | probably_damaging(0.936) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR |
COMMD4 | SNV | Missense_Mutation | c.222N>A | p.Phe74Leu | p.F74L | Q9H0A8 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
COMMD4 | SNV | Missense_Mutation | c.547N>A | p.Val183Ile | p.V183I | Q9H0A8 | protein_coding | deleterious(0.03) | possibly_damaging(0.675) | TCGA-AA-3673-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
COMMD4 | SNV | Missense_Mutation | c.185C>T | p.Ser62Leu | p.S62L | Q9H0A8 | protein_coding | tolerated(0.28) | benign(0.009) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
COMMD4 | SNV | Missense_Mutation | novel | c.511N>T | p.Pro171Ser | p.P171S | Q9H0A8 | protein_coding | tolerated(0.27) | benign(0.048) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COMMD4 | SNV | Missense_Mutation | novel | c.257N>A | p.Gly86Asp | p.G86D | Q9H0A8 | protein_coding | tolerated(0.15) | possibly_damaging(0.745) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
COMMD4 | SNV | Missense_Mutation | novel | c.311N>T | p.Ala104Val | p.A104V | Q9H0A8 | protein_coding | tolerated(0.25) | benign(0.029) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
COMMD4 | SNV | Missense_Mutation | novel | c.72G>T | p.Lys24Asn | p.K24N | Q9H0A8 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
COMMD4 | SNV | Missense_Mutation | novel | c.37N>A | p.Asp13Asn | p.D13N | Q9H0A8 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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