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Gene: COMMD10 |
Gene summary for COMMD10 |
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Gene information | Species | Human | Gene symbol | COMMD10 | Gene ID | 51397 |
Gene name | COMM domain containing 10 | |
Gene Alias | PTD002 | |
Cytomap | 5q23.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | D6RJ90 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51397 | COMMD10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.48e-24 | -7.59e-01 | 0.0155 |
51397 | COMMD10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.38e-07 | -6.52e-01 | -0.1808 |
51397 | COMMD10 | HTA11_2951_2000001011 | Human | Colorectum | AD | 8.77e-04 | -8.77e-01 | 0.0216 |
51397 | COMMD10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.02e-05 | -5.16e-01 | -0.0811 |
51397 | COMMD10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.62e-14 | -8.79e-01 | -0.1207 |
51397 | COMMD10 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.14e-20 | -6.58e-01 | -0.1464 |
51397 | COMMD10 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.92e-13 | -5.59e-01 | -0.1001 |
51397 | COMMD10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.72e-09 | -6.02e-01 | -0.059 |
51397 | COMMD10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.36e-03 | -7.28e-01 | -0.2061 |
51397 | COMMD10 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.98e-03 | -7.34e-01 | -0.1462 |
51397 | COMMD10 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.38e-06 | -7.31e-01 | -0.0179 |
51397 | COMMD10 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.67e-14 | -6.40e-01 | 0.096 |
51397 | COMMD10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.42e-08 | -9.30e-01 | 0.0528 |
51397 | COMMD10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.10e-10 | -7.42e-01 | 0.0338 |
51397 | COMMD10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.03e-23 | -6.75e-01 | 0.0674 |
51397 | COMMD10 | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.61e-06 | -7.27e-01 | 0.0112 |
51397 | COMMD10 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.53e-02 | -5.42e-01 | 0.0588 |
51397 | COMMD10 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.64e-15 | -5.42e-01 | 0.294 |
51397 | COMMD10 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.18e-22 | -6.94e-01 | 0.3859 |
51397 | COMMD10 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 4.58e-07 | -7.75e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COMMD10 | SNV | Missense_Mutation | c.172N>G | p.Gln58Glu | p.Q58E | Q9Y6G5 | protein_coding | tolerated(0.14) | benign(0.429) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
COMMD10 | SNV | Missense_Mutation | novel | c.380N>T | p.Arg127Ile | p.R127I | Q9Y6G5 | protein_coding | deleterious(0.01) | probably_damaging(0.933) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
COMMD10 | SNV | Missense_Mutation | c.341C>T | p.Ser114Phe | p.S114F | Q9Y6G5 | protein_coding | deleterious(0) | possibly_damaging(0.827) | TCGA-BH-A0H6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COMMD10 | insertion | In_Frame_Ins | novel | c.465_466insTTAAATATA | p.Ser155_Pro156insLeuAsnIle | p.S155_P156insLNI | Q9Y6G5 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
COMMD10 | SNV | Missense_Mutation | novel | c.569A>G | p.Lys190Arg | p.K190R | Q9Y6G5 | protein_coding | deleterious(0.03) | benign(0.026) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
COMMD10 | SNV | Missense_Mutation | c.451G>A | p.Ala151Thr | p.A151T | Q9Y6G5 | protein_coding | tolerated(0.16) | benign(0.356) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COMMD10 | SNV | Missense_Mutation | c.570G>T | p.Lys190Asn | p.K190N | Q9Y6G5 | protein_coding | tolerated(0.19) | benign(0.079) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
COMMD10 | SNV | Missense_Mutation | c.322G>T | p.Ala108Ser | p.A108S | Q9Y6G5 | protein_coding | deleterious(0.04) | benign(0.331) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
COMMD10 | insertion | Frame_Shift_Ins | novel | c.303_304insCATACTG | p.Arg102HisfsTer8 | p.R102Hfs*8 | Q9Y6G5 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
COMMD10 | SNV | Missense_Mutation | novel | c.119N>C | p.Lys40Thr | p.K40T | Q9Y6G5 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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