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Gene: COLCA1 |
Gene summary for COLCA1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | COLCA1 | Gene ID | 399948 |
| Gene name | colorectal cancer associated 1 | |
| Gene Alias | C11orf92 | |
| Cytomap | 11q23.1 | |
| Gene Type | ncRNA | GO ID | GO:0005575 | UniProtAcc | Q6ZS62 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 399948 | COLCA1 | LZE5T | Human | Esophagus | ESCC | 1.57e-02 | 1.77e-01 | 0.0514 |
| 399948 | COLCA1 | LZE7T | Human | Esophagus | ESCC | 1.62e-04 | 2.68e-01 | 0.0667 |
| 399948 | COLCA1 | LZE20T | Human | Esophagus | ESCC | 4.98e-02 | 1.15e-01 | 0.0662 |
| 399948 | COLCA1 | LZE21T | Human | Esophagus | ESCC | 6.52e-03 | 2.38e-01 | 0.0655 |
| 399948 | COLCA1 | P2T-E | Human | Esophagus | ESCC | 3.75e-03 | 7.06e-02 | 0.1177 |
| 399948 | COLCA1 | P4T-E | Human | Esophagus | ESCC | 2.90e-03 | 1.13e-01 | 0.1323 |
| 399948 | COLCA1 | P5T-E | Human | Esophagus | ESCC | 2.60e-12 | 3.01e-01 | 0.1327 |
| 399948 | COLCA1 | P8T-E | Human | Esophagus | ESCC | 8.27e-06 | 1.30e-01 | 0.0889 |
| 399948 | COLCA1 | P9T-E | Human | Esophagus | ESCC | 5.41e-23 | 5.57e-01 | 0.1131 |
| 399948 | COLCA1 | P15T-E | Human | Esophagus | ESCC | 3.34e-06 | 1.36e-01 | 0.1149 |
| 399948 | COLCA1 | P16T-E | Human | Esophagus | ESCC | 1.18e-03 | 3.83e-02 | 0.1153 |
| 399948 | COLCA1 | P22T-E | Human | Esophagus | ESCC | 6.32e-08 | 1.54e-01 | 0.1236 |
| 399948 | COLCA1 | P23T-E | Human | Esophagus | ESCC | 1.31e-04 | 1.25e-01 | 0.108 |
| 399948 | COLCA1 | P30T-E | Human | Esophagus | ESCC | 9.17e-18 | 5.11e-01 | 0.137 |
| 399948 | COLCA1 | P39T-E | Human | Esophagus | ESCC | 5.70e-06 | 1.57e-01 | 0.0894 |
| 399948 | COLCA1 | P47T-E | Human | Esophagus | ESCC | 4.59e-04 | 5.11e-02 | 0.1067 |
| 399948 | COLCA1 | P48T-E | Human | Esophagus | ESCC | 4.74e-06 | 6.61e-02 | 0.0959 |
| 399948 | COLCA1 | P54T-E | Human | Esophagus | ESCC | 2.11e-02 | 9.32e-02 | 0.0975 |
| 399948 | COLCA1 | P57T-E | Human | Esophagus | ESCC | 2.22e-06 | 1.07e-01 | 0.0926 |
| 399948 | COLCA1 | P62T-E | Human | Esophagus | ESCC | 2.57e-02 | 7.57e-02 | 0.1302 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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