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Gene: COIL |
Gene summary for COIL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | COIL | Gene ID | 8161 |
| Gene name | coilin | |
| Gene Alias | CLN80 | |
| Cytomap | 17q22 | |
| Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | P38432 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8161 | COIL | LZE2T | Human | Esophagus | ESCC | 3.47e-02 | 3.45e-01 | 0.082 |
| 8161 | COIL | LZE4T | Human | Esophagus | ESCC | 4.90e-14 | 3.28e-01 | 0.0811 |
| 8161 | COIL | LZE7T | Human | Esophagus | ESCC | 5.42e-07 | 3.13e-01 | 0.0667 |
| 8161 | COIL | LZE8T | Human | Esophagus | ESCC | 1.05e-02 | 1.08e-01 | 0.067 |
| 8161 | COIL | LZE20T | Human | Esophagus | ESCC | 6.21e-05 | 2.01e-01 | 0.0662 |
| 8161 | COIL | LZE24T | Human | Esophagus | ESCC | 9.86e-15 | 4.03e-01 | 0.0596 |
| 8161 | COIL | LZE21T | Human | Esophagus | ESCC | 2.52e-04 | 3.59e-01 | 0.0655 |
| 8161 | COIL | P1T-E | Human | Esophagus | ESCC | 2.24e-14 | 7.06e-01 | 0.0875 |
| 8161 | COIL | P2T-E | Human | Esophagus | ESCC | 5.28e-33 | 6.22e-01 | 0.1177 |
| 8161 | COIL | P4T-E | Human | Esophagus | ESCC | 3.04e-23 | 4.43e-01 | 0.1323 |
| 8161 | COIL | P5T-E | Human | Esophagus | ESCC | 7.69e-11 | 2.00e-01 | 0.1327 |
| 8161 | COIL | P8T-E | Human | Esophagus | ESCC | 1.51e-29 | 4.87e-01 | 0.0889 |
| 8161 | COIL | P9T-E | Human | Esophagus | ESCC | 1.24e-14 | 2.98e-01 | 0.1131 |
| 8161 | COIL | P10T-E | Human | Esophagus | ESCC | 2.33e-27 | 4.83e-01 | 0.116 |
| 8161 | COIL | P11T-E | Human | Esophagus | ESCC | 5.53e-11 | 4.57e-01 | 0.1426 |
| 8161 | COIL | P12T-E | Human | Esophagus | ESCC | 6.47e-28 | 4.75e-01 | 0.1122 |
| 8161 | COIL | P15T-E | Human | Esophagus | ESCC | 9.87e-26 | 6.12e-01 | 0.1149 |
| 8161 | COIL | P16T-E | Human | Esophagus | ESCC | 4.77e-33 | 6.02e-01 | 0.1153 |
| 8161 | COIL | P17T-E | Human | Esophagus | ESCC | 1.33e-07 | 3.17e-01 | 0.1278 |
| 8161 | COIL | P20T-E | Human | Esophagus | ESCC | 3.76e-24 | 4.48e-01 | 0.1124 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022613111 | Esophagus | ESCC | ribonucleoprotein complex biogenesis | 365/8552 | 463/18723 | 1.74e-49 | 1.11e-45 | 365 |
| GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
| GO:0000375111 | Esophagus | ESCC | RNA splicing, via transesterification reactions | 248/8552 | 324/18723 | 3.05e-30 | 1.49e-27 | 248 |
| GO:0000377111 | Esophagus | ESCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
| GO:0000398111 | Esophagus | ESCC | mRNA splicing, via spliceosome | 244/8552 | 320/18723 | 2.52e-29 | 1.07e-26 | 244 |
| GO:0071826111 | Esophagus | ESCC | ribonucleoprotein complex subunit organization | 166/8552 | 227/18723 | 2.94e-17 | 2.42e-15 | 166 |
| GO:0022618111 | Esophagus | ESCC | ribonucleoprotein complex assembly | 159/8552 | 220/18723 | 8.19e-16 | 5.71e-14 | 159 |
| GO:00003875 | Esophagus | ESCC | spliceosomal snRNP assembly | 32/8552 | 50/18723 | 6.90e-03 | 2.52e-02 | 32 |
| GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
| GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
| GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
| GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
| GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
| GO:007182622 | Liver | HCC | ribonucleoprotein complex subunit organization | 159/7958 | 227/18723 | 3.14e-17 | 3.06e-15 | 159 |
| GO:002261822 | Liver | HCC | ribonucleoprotein complex assembly | 153/7958 | 220/18723 | 3.44e-16 | 2.91e-14 | 153 |
| GO:00003872 | Liver | HCC | spliceosomal snRNP assembly | 31/7958 | 50/18723 | 4.23e-03 | 1.84e-02 | 31 |
| GO:002261320 | Oral cavity | OSCC | ribonucleoprotein complex biogenesis | 333/7305 | 463/18723 | 8.28e-48 | 5.24e-44 | 333 |
| GO:000838020 | Oral cavity | OSCC | RNA splicing | 308/7305 | 434/18723 | 2.43e-42 | 7.70e-39 | 308 |
| GO:000037519 | Oral cavity | OSCC | RNA splicing, via transesterification reactions | 225/7305 | 324/18723 | 5.20e-29 | 2.99e-26 | 225 |
| GO:000037719 | Oral cavity | OSCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 221/7305 | 320/18723 | 5.50e-28 | 2.18e-25 | 221 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| COIL | SNV | Missense_Mutation | c.775N>A | p.Asp259Asn | p.D259N | P38432 | protein_coding | deleterious(0.05) | benign(0.027) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| COIL | SNV | Missense_Mutation | c.1543N>G | p.Leu515Val | p.L515V | P38432 | protein_coding | deleterious(0.03) | possibly_damaging(0.508) | TCGA-OL-A5DA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| COIL | SNV | Missense_Mutation | c.984G>C | p.Leu328Phe | p.L328F | P38432 | protein_coding | deleterious(0.03) | benign(0.103) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| COIL | SNV | Missense_Mutation | c.373G>C | p.Asp125His | p.D125H | P38432 | protein_coding | deleterious(0.02) | possibly_damaging(0.742) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| COIL | SNV | Missense_Mutation | c.984G>C | p.Leu328Phe | p.L328F | P38432 | protein_coding | deleterious(0.03) | benign(0.103) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
| COIL | SNV | Missense_Mutation | novel | c.557N>C | p.Lys186Thr | p.K186T | P38432 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| COIL | SNV | Missense_Mutation | novel | c.1553N>C | p.Leu518Ser | p.L518S | P38432 | protein_coding | tolerated(0.36) | benign(0.03) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| COIL | SNV | Missense_Mutation | novel | c.1496N>T | p.Arg499Ile | p.R499I | P38432 | protein_coding | deleterious(0.01) | benign(0.088) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| COIL | SNV | Missense_Mutation | novel | c.527N>G | p.Asp176Gly | p.D176G | P38432 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| COIL | SNV | Missense_Mutation | c.1543N>A | p.Leu515Ile | p.L515I | P38432 | protein_coding | tolerated(0.08) | possibly_damaging(0.573) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 8161 | COIL | NA | EGCG | EPIGALOCATECHIN GALLATE | 16046615 | |
| 8161 | COIL | NA | ACTINOMYCIN D | 2088441 | ||
| 8161 | COIL | NA | ANTI-P80 | 16246523 |
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