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Gene: COCH |
Gene summary for COCH |
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Gene information | Species | Human | Gene symbol | COCH | Gene ID | 1690 |
Gene name | cochlin | |
Gene Alias | COCH-5B2 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O43405 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1690 | COCH | LZE4T | Human | Esophagus | ESCC | 3.18e-05 | 1.99e-01 | 0.0811 |
1690 | COCH | LZE7T | Human | Esophagus | ESCC | 4.33e-11 | 5.17e-01 | 0.0667 |
1690 | COCH | LZE24T | Human | Esophagus | ESCC | 4.15e-02 | 1.17e-01 | 0.0596 |
1690 | COCH | P8T-E | Human | Esophagus | ESCC | 5.03e-37 | 7.63e-01 | 0.0889 |
1690 | COCH | P22T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.66e-01 | 0.1236 |
1690 | COCH | P26T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.29e-01 | 0.1276 |
1690 | COCH | P28T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.56e-01 | 0.1149 |
1690 | COCH | P30T-E | Human | Esophagus | ESCC | 4.41e-11 | 3.76e-01 | 0.137 |
1690 | COCH | P31T-E | Human | Esophagus | ESCC | 8.40e-04 | 9.90e-02 | 0.1251 |
1690 | COCH | P36T-E | Human | Esophagus | ESCC | 7.72e-03 | 1.35e-01 | 0.1187 |
1690 | COCH | P37T-E | Human | Esophagus | ESCC | 4.28e-02 | 8.36e-02 | 0.1371 |
1690 | COCH | P48T-E | Human | Esophagus | ESCC | 7.90e-03 | 9.25e-02 | 0.0959 |
1690 | COCH | P52T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.24e-01 | 0.1555 |
1690 | COCH | P61T-E | Human | Esophagus | ESCC | 4.69e-32 | 7.93e-01 | 0.099 |
1690 | COCH | P76T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.09e-01 | 0.1207 |
1690 | COCH | P79T-E | Human | Esophagus | ESCC | 4.30e-10 | 2.73e-01 | 0.1154 |
1690 | COCH | P83T-E | Human | Esophagus | ESCC | 6.66e-04 | 1.72e-01 | 0.1738 |
1690 | COCH | P107T-E | Human | Esophagus | ESCC | 3.51e-03 | 1.18e-01 | 0.171 |
1690 | COCH | P128T-E | Human | Esophagus | ESCC | 3.30e-12 | 3.99e-01 | 0.1241 |
1690 | COCH | P130T-E | Human | Esophagus | ESCC | 6.89e-44 | 1.17e+00 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:000836018 | Esophagus | ESCC | regulation of cell shape | 92/8552 | 154/18723 | 3.00e-04 | 1.81e-03 | 92 |
GO:00450885 | Esophagus | ESCC | regulation of innate immune response | 125/8552 | 218/18723 | 3.34e-04 | 1.96e-03 | 125 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
COCH | SNV | Missense_Mutation | rs775781203 | c.282C>A | p.Ser94Arg | p.S94R | O43405 | protein_coding | tolerated(0.13) | benign(0.025) | TCGA-A8-A091-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD |
COCH | SNV | Missense_Mutation | c.625N>C | p.Ala209Pro | p.A209P | O43405 | protein_coding | tolerated(0.11) | possibly_damaging(0.848) | TCGA-E9-A1RF-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
COCH | SNV | Missense_Mutation | novel | c.1119T>G | p.Asp373Glu | p.D373E | O43405 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-LL-A441-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
COCH | insertion | Frame_Shift_Ins | novel | c.873_874insGTAGCAAGGCAAAAAGACCGCCTCAAAGTCGCTGCCCTTGGGGC | p.Phe292ValfsTer22 | p.F292Vfs*22 | O43405 | protein_coding | TCGA-BH-A1EY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
COCH | SNV | Missense_Mutation | c.1252N>C | p.Glu418Gln | p.E418Q | O43405 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-C5-A7CH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | SD | ||
COCH | SNV | Missense_Mutation | c.1606N>C | p.Asp536His | p.D536H | O43405 | protein_coding | tolerated(0.08) | possibly_damaging(0.694) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
COCH | SNV | Missense_Mutation | c.239G>T | p.Arg80Met | p.R80M | O43405 | protein_coding | deleterious(0.02) | possibly_damaging(0.756) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
COCH | SNV | Missense_Mutation | novel | c.770N>T | p.Thr257Met | p.T257M | O43405 | protein_coding | deleterious(0) | possibly_damaging(0.807) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
COCH | SNV | Missense_Mutation | novel | c.132G>T | p.Glu44Asp | p.E44D | O43405 | protein_coding | tolerated(0.31) | benign(0.007) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
COCH | SNV | Missense_Mutation | novel | c.230C>A | p.Ala77Asp | p.A77D | O43405 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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