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Gene: COBL |
Gene summary for COBL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | COBL | Gene ID | 23242 |
| Gene name | cordon-bleu WH2 repeat protein | |
| Gene Alias | COBL | |
| Cytomap | 7p12.1 | |
| Gene Type | protein-coding | GO ID | GO:0000578 | UniProtAcc | O75128 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23242 | COBL | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.76e-11 | -5.01e-01 | 0.0155 |
| 23242 | COBL | HTA11_347_2000001011 | Human | Colorectum | AD | 1.95e-14 | 6.70e-01 | -0.1954 |
| 23242 | COBL | HTA11_411_2000001011 | Human | Colorectum | SER | 9.75e-03 | 8.30e-01 | -0.2602 |
| 23242 | COBL | HTA11_696_2000001011 | Human | Colorectum | AD | 3.23e-05 | 4.18e-01 | -0.1464 |
| 23242 | COBL | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.46e-02 | -3.60e-01 | 0.294 |
| 23242 | COBL | A015-C-203 | Human | Colorectum | FAP | 2.41e-13 | -3.60e-01 | -0.1294 |
| 23242 | COBL | A015-C-204 | Human | Colorectum | FAP | 1.24e-02 | -2.81e-01 | -0.0228 |
| 23242 | COBL | A002-C-201 | Human | Colorectum | FAP | 7.06e-08 | -3.29e-01 | 0.0324 |
| 23242 | COBL | A001-C-108 | Human | Colorectum | FAP | 5.61e-04 | -1.73e-01 | -0.0272 |
| 23242 | COBL | A002-C-205 | Human | Colorectum | FAP | 6.75e-14 | -3.56e-01 | -0.1236 |
| 23242 | COBL | A015-C-006 | Human | Colorectum | FAP | 5.93e-06 | -2.26e-01 | -0.0994 |
| 23242 | COBL | A015-C-106 | Human | Colorectum | FAP | 8.45e-03 | -1.63e-01 | -0.0511 |
| 23242 | COBL | A002-C-114 | Human | Colorectum | FAP | 7.78e-10 | -2.47e-01 | -0.1561 |
| 23242 | COBL | A015-C-104 | Human | Colorectum | FAP | 1.57e-14 | -3.01e-01 | -0.1899 |
| 23242 | COBL | A001-C-014 | Human | Colorectum | FAP | 1.37e-02 | -1.76e-01 | 0.0135 |
| 23242 | COBL | A002-C-016 | Human | Colorectum | FAP | 7.60e-13 | -3.30e-01 | 0.0521 |
| 23242 | COBL | A015-C-002 | Human | Colorectum | FAP | 1.34e-04 | -2.94e-01 | -0.0763 |
| 23242 | COBL | A001-C-203 | Human | Colorectum | FAP | 7.08e-05 | -1.73e-01 | -0.0481 |
| 23242 | COBL | A002-C-116 | Human | Colorectum | FAP | 1.10e-15 | -3.61e-01 | -0.0452 |
| 23242 | COBL | A014-C-008 | Human | Colorectum | FAP | 1.51e-06 | -2.00e-01 | -0.191 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
| GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
| GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
| GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
| GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
| GO:0016049 | Colorectum | AD | cell growth | 143/3918 | 482/18723 | 2.83e-06 | 8.09e-05 | 143 |
| GO:0061008 | Colorectum | AD | hepaticobiliary system development | 55/3918 | 150/18723 | 6.34e-06 | 1.59e-04 | 55 |
| GO:0001889 | Colorectum | AD | liver development | 54/3918 | 147/18723 | 7.20e-06 | 1.77e-04 | 54 |
| GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
| GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
| GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
| GO:0061564 | Colorectum | AD | axon development | 132/3918 | 467/18723 | 8.40e-05 | 1.31e-03 | 132 |
| GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
| GO:0014020 | Colorectum | AD | primary neural tube formation | 33/3918 | 94/18723 | 1.02e-03 | 9.50e-03 | 33 |
| GO:0001841 | Colorectum | AD | neural tube formation | 35/3918 | 102/18723 | 1.16e-03 | 1.05e-02 | 35 |
| GO:0001843 | Colorectum | AD | neural tube closure | 30/3918 | 88/18723 | 2.83e-03 | 2.12e-02 | 30 |
| GO:0048588 | Colorectum | AD | developmental cell growth | 67/3918 | 234/18723 | 3.03e-03 | 2.25e-02 | 67 |
| GO:0016358 | Colorectum | AD | dendrite development | 69/3918 | 243/18723 | 3.32e-03 | 2.42e-02 | 69 |
| GO:0060606 | Colorectum | AD | tube closure | 30/3918 | 89/18723 | 3.42e-03 | 2.49e-02 | 30 |
| GO:0035148 | Colorectum | AD | tube formation | 45/3918 | 148/18723 | 4.13e-03 | 2.87e-02 | 45 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| COBL | SNV | Missense_Mutation | c.3280N>C | p.Val1094Leu | p.V1094L | O75128 | protein_coding | tolerated(0.31) | benign(0) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| COBL | SNV | Missense_Mutation | novel | c.3233C>T | p.Pro1078Leu | p.P1078L | O75128 | protein_coding | tolerated(0.32) | benign(0.003) | TCGA-AR-A2LR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| COBL | SNV | Missense_Mutation | c.271G>A | p.Glu91Lys | p.E91K | O75128 | protein_coding | deleterious(0.01) | possibly_damaging(0.721) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
| COBL | insertion | Frame_Shift_Ins | novel | c.1912_1913insAACTACTCAGGGGACTGAGGTGGGAAGAT | p.Pro638GlnfsTer54 | p.P638Qfs*54 | O75128 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| COBL | insertion | In_Frame_Ins | novel | c.1040_1041insGGTTCATTTTCTTTTTAAATCATTCAGCATTTGTTATTTCACTTACGT | p.Ser347delinsArgValHisPheLeuPheLysSerPheSerIleCysTyrPheThrTyrVal | p.S347delinsRVHFLFKSFSICYFTYV | O75128 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| COBL | insertion | Frame_Shift_Ins | novel | c.3405_3406insTTTGTATTTTTAGTAGAGACAGG | p.Glu1136PhefsTer43 | p.E1136Ffs*43 | O75128 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| COBL | insertion | Frame_Shift_Ins | novel | c.3746_3747insCTCGTACATGCTTGCATTCCAGCCTAATGTTGGACAGTTACGGAAT | p.Gln1249HisfsTer64 | p.Q1249Hfs*64 | O75128 | protein_coding | TCGA-A8-A090-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| COBL | insertion | Nonsense_Mutation | novel | c.2686_2687insGATATTTGTACTGA | p.Met896ArgfsTer5 | p.M896Rfs*5 | O75128 | protein_coding | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| COBL | deletion | Frame_Shift_Del | c.130delN | p.Ala44ProfsTer11 | p.A44Pfs*11 | O75128 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| COBL | insertion | Frame_Shift_Ins | novel | c.2195_2196insGCCCATTGGGAAAGTCAGAGAGTTCTGGAGGTGCAACTCTG | p.Asp732GlufsTer80 | p.D732Efs*80 | O75128 | protein_coding | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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