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Gene: CNOT8 |
Gene summary for CNOT8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CNOT8 | Gene ID | 9337 |
| Gene name | CCR4-NOT transcription complex subunit 8 | |
| Gene Alias | CAF1 | |
| Cytomap | 5q33.2 | |
| Gene Type | protein-coding | GO ID | GO:0000288 | UniProtAcc | Q9UFF9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9337 | CNOT8 | LZE4T | Human | Esophagus | ESCC | 1.32e-06 | 2.49e-01 | 0.0811 |
| 9337 | CNOT8 | LZE7T | Human | Esophagus | ESCC | 2.41e-09 | 4.96e-01 | 0.0667 |
| 9337 | CNOT8 | LZE8T | Human | Esophagus | ESCC | 6.40e-06 | 2.21e-01 | 0.067 |
| 9337 | CNOT8 | LZE24T | Human | Esophagus | ESCC | 3.27e-19 | 4.27e-01 | 0.0596 |
| 9337 | CNOT8 | LZE6T | Human | Esophagus | ESCC | 1.69e-09 | 3.69e-01 | 0.0845 |
| 9337 | CNOT8 | P1T-E | Human | Esophagus | ESCC | 7.29e-07 | 4.60e-01 | 0.0875 |
| 9337 | CNOT8 | P2T-E | Human | Esophagus | ESCC | 7.27e-40 | 6.04e-01 | 0.1177 |
| 9337 | CNOT8 | P4T-E | Human | Esophagus | ESCC | 3.49e-30 | 4.99e-01 | 0.1323 |
| 9337 | CNOT8 | P5T-E | Human | Esophagus | ESCC | 6.51e-20 | 2.80e-01 | 0.1327 |
| 9337 | CNOT8 | P8T-E | Human | Esophagus | ESCC | 2.01e-16 | 3.22e-01 | 0.0889 |
| 9337 | CNOT8 | P9T-E | Human | Esophagus | ESCC | 4.43e-09 | 1.88e-01 | 0.1131 |
| 9337 | CNOT8 | P10T-E | Human | Esophagus | ESCC | 5.33e-23 | 3.77e-01 | 0.116 |
| 9337 | CNOT8 | P11T-E | Human | Esophagus | ESCC | 2.17e-17 | 5.34e-01 | 0.1426 |
| 9337 | CNOT8 | P12T-E | Human | Esophagus | ESCC | 3.82e-31 | 5.44e-01 | 0.1122 |
| 9337 | CNOT8 | P15T-E | Human | Esophagus | ESCC | 1.13e-24 | 5.62e-01 | 0.1149 |
| 9337 | CNOT8 | P16T-E | Human | Esophagus | ESCC | 1.58e-24 | 3.66e-01 | 0.1153 |
| 9337 | CNOT8 | P17T-E | Human | Esophagus | ESCC | 1.93e-06 | 2.77e-01 | 0.1278 |
| 9337 | CNOT8 | P20T-E | Human | Esophagus | ESCC | 8.61e-18 | 2.68e-01 | 0.1124 |
| 9337 | CNOT8 | P21T-E | Human | Esophagus | ESCC | 3.73e-23 | 3.76e-01 | 0.1617 |
| 9337 | CNOT8 | P22T-E | Human | Esophagus | ESCC | 4.88e-36 | 5.27e-01 | 0.1236 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009896111 | Esophagus | ESCC | positive regulation of catabolic process | 332/8552 | 492/18723 | 4.36e-23 | 9.22e-21 | 332 |
| GO:0031331111 | Esophagus | ESCC | positive regulation of cellular catabolic process | 292/8552 | 427/18723 | 8.67e-22 | 1.53e-19 | 292 |
| GO:1903311110 | Esophagus | ESCC | regulation of mRNA metabolic process | 210/8552 | 288/18723 | 3.25e-21 | 5.56e-19 | 210 |
| GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
| GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
| GO:0006402110 | Esophagus | ESCC | mRNA catabolic process | 170/8552 | 232/18723 | 8.70e-18 | 8.00e-16 | 170 |
| GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
| GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
| GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
| GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
| GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
| GO:000095618 | Esophagus | ESCC | nuclear-transcribed mRNA catabolic process | 88/8552 | 112/18723 | 9.41e-13 | 4.14e-11 | 88 |
| GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
| GO:190331316 | Esophagus | ESCC | positive regulation of mRNA metabolic process | 87/8552 | 118/18723 | 5.10e-10 | 1.32e-08 | 87 |
| GO:006101319 | Esophagus | ESCC | regulation of mRNA catabolic process | 115/8552 | 166/18723 | 5.90e-10 | 1.49e-08 | 115 |
| GO:004348719 | Esophagus | ESCC | regulation of RNA stability | 117/8552 | 170/18723 | 7.91e-10 | 1.94e-08 | 117 |
| GO:004348819 | Esophagus | ESCC | regulation of mRNA stability | 109/8552 | 158/18723 | 2.40e-09 | 5.35e-08 | 109 |
| GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
| GO:006101416 | Esophagus | ESCC | positive regulation of mRNA catabolic process | 63/8552 | 87/18723 | 3.70e-07 | 5.15e-06 | 63 |
| GO:006115716 | Esophagus | ESCC | mRNA destabilization | 61/8552 | 84/18723 | 4.81e-07 | 6.49e-06 | 61 |
| Page: 1 2 3 4 5 6 7 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0301824 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
| hsa0301834 | Esophagus | ESCC | RNA degradation | 62/4205 | 79/8465 | 1.18e-07 | 9.39e-07 | 4.81e-07 | 62 |
| hsa030182 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
| hsa030183 | Liver | HCC | RNA degradation | 58/4020 | 79/8465 | 2.29e-06 | 2.19e-05 | 1.22e-05 | 58 |
| hsa030189 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
| hsa0301814 | Oral cavity | OSCC | RNA degradation | 59/3704 | 79/8465 | 2.05e-08 | 1.91e-07 | 9.70e-08 | 59 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CNOT8 | SNV | Missense_Mutation | c.800N>T | p.Ala267Val | p.A267V | Q9UFF9 | protein_coding | tolerated(0.36) | benign(0.003) | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| CNOT8 | SNV | Missense_Mutation | c.205G>A | p.Val69Ile | p.V69I | Q9UFF9 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
| CNOT8 | insertion | Frame_Shift_Ins | novel | c.104_105insTTATA | p.Ala38IlefsTer23 | p.A38Ifs*23 | Q9UFF9 | protein_coding | TCGA-C5-A2M1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
| CNOT8 | SNV | Missense_Mutation | c.353N>T | p.Asn118Ile | p.N118I | Q9UFF9 | protein_coding | deleterious(0.02) | possibly_damaging(0.61) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| CNOT8 | SNV | Missense_Mutation | c.508N>G | p.Thr170Ala | p.T170A | Q9UFF9 | protein_coding | deleterious(0) | benign(0.279) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| CNOT8 | SNV | Missense_Mutation | novel | c.164N>A | p.Arg55His | p.R55H | Q9UFF9 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| CNOT8 | SNV | Missense_Mutation | novel | c.340N>T | p.Asp114Tyr | p.D114Y | Q9UFF9 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
| CNOT8 | SNV | Missense_Mutation | novel | c.854N>T | p.Ala285Val | p.A285V | Q9UFF9 | protein_coding | deleterious(0.01) | possibly_damaging(0.499) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| CNOT8 | SNV | Missense_Mutation | c.266N>T | p.Pro89Leu | p.P89L | Q9UFF9 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-A5-A0GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CNOT8 | SNV | Missense_Mutation | c.250N>A | p.Glu84Lys | p.E84K | Q9UFF9 | protein_coding | deleterious(0.04) | benign(0.222) | TCGA-AP-A05J-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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