Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CNOT11

Gene summary for CNOT11

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CNOT11

Gene ID

55571

Gene nameCCR4-NOT transcription complex subunit 11
Gene AliasC2orf29
Cytomap2q11.2
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q9UKZ1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
55571CNOT11LZE2THumanEsophagusESCC2.50e-023.72e-010.082
55571CNOT11LZE7THumanEsophagusESCC9.44e-041.52e-010.0667
55571CNOT11LZE24THumanEsophagusESCC2.12e-041.96e-010.0596
55571CNOT11P2T-EHumanEsophagusESCC1.39e-234.21e-010.1177
55571CNOT11P4T-EHumanEsophagusESCC1.82e-103.67e-010.1323
55571CNOT11P5T-EHumanEsophagusESCC9.56e-153.17e-010.1327
55571CNOT11P8T-EHumanEsophagusESCC7.43e-101.53e-010.0889
55571CNOT11P9T-EHumanEsophagusESCC2.31e-092.90e-010.1131
55571CNOT11P10T-EHumanEsophagusESCC3.98e-111.79e-010.116
55571CNOT11P11T-EHumanEsophagusESCC1.57e-021.35e-010.1426
55571CNOT11P12T-EHumanEsophagusESCC7.99e-111.88e-010.1122
55571CNOT11P15T-EHumanEsophagusESCC1.33e-123.08e-010.1149
55571CNOT11P16T-EHumanEsophagusESCC4.73e-076.66e-020.1153
55571CNOT11P20T-EHumanEsophagusESCC8.09e-071.22e-010.1124
55571CNOT11P21T-EHumanEsophagusESCC9.02e-203.45e-010.1617
55571CNOT11P22T-EHumanEsophagusESCC3.33e-101.22e-010.1236
55571CNOT11P23T-EHumanEsophagusESCC1.62e-164.66e-010.108
55571CNOT11P24T-EHumanEsophagusESCC2.47e-071.84e-010.1287
55571CNOT11P26T-EHumanEsophagusESCC1.26e-183.76e-010.1276
55571CNOT11P27T-EHumanEsophagusESCC1.81e-091.58e-010.1055
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006401110EsophagusESCCRNA catabolic process204/8552278/187233.39e-215.66e-19204
GO:0034655110EsophagusESCCnucleobase-containing compound catabolic process272/8552407/187232.92e-182.90e-16272
GO:0006402110EsophagusESCCmRNA catabolic process170/8552232/187238.70e-188.00e-16170
GO:0006417111EsophagusESCCregulation of translation304/8552468/187231.53e-171.33e-15304
GO:004670018EsophagusESCCheterocycle catabolic process286/8552445/187231.12e-157.47e-14286
GO:004427019EsophagusESCCcellular nitrogen compound catabolic process288/8552451/187233.03e-151.79e-13288
GO:001943918EsophagusESCCaromatic compound catabolic process295/8552467/187231.09e-145.98e-13295
GO:190136118EsophagusESCCorganic cyclic compound catabolic process307/8552495/187239.99e-144.80e-12307
GO:003424914EsophagusESCCnegative regulation of cellular amide metabolic process144/8552273/187231.08e-023.67e-02144
GO:004427021LiverHCCcellular nitrogen compound catabolic process303/7958451/187239.76e-273.64e-24303
GO:004670021LiverHCCheterocycle catabolic process299/7958445/187232.07e-267.29e-24299
GO:190136121LiverHCCorganic cyclic compound catabolic process325/7958495/187236.52e-262.18e-23325
GO:001943921LiverHCCaromatic compound catabolic process309/7958467/187231.56e-254.94e-23309
GO:000640121LiverHCCRNA catabolic process201/7958278/187233.88e-241.02e-21201
GO:003465521LiverHCCnucleobase-containing compound catabolic process273/7958407/187234.84e-241.23e-21273
GO:000640221LiverHCCmRNA catabolic process169/7958232/187234.50e-216.96e-19169
GO:000641722LiverHCCregulation of translation287/7958468/187238.79e-178.08e-15287
GO:003424921LiverHCCnegative regulation of cellular amide metabolic process144/7958273/187233.80e-042.61e-03144
GO:001714821LiverHCCnegative regulation of translation129/7958245/187238.14e-044.87e-03129
GO:000640118Oral cavityOSCCRNA catabolic process184/7305278/187232.71e-204.19e-18184
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CNOT11SNVMissense_Mutationnovelc.317C>Tp.Ser106Leup.S106LQ9UKZ1protein_codingtolerated(0.71)benign(0.148)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
CNOT11SNVMissense_Mutationc.913N>Ap.Glu305Lysp.E305KQ9UKZ1protein_codingtolerated(0.07)benign(0.304)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
CNOT11SNVMissense_Mutationnovelc.736G>Ap.Asp246Asnp.D246NQ9UKZ1protein_codingdeleterious(0.03)probably_damaging(0.989)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
CNOT11SNVMissense_Mutationc.76N>Tp.Ala26Serp.A26SQ9UKZ1protein_codingdeleterious_low_confidence(0)benign(0.001)TCGA-A6-5659-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
CNOT11SNVMissense_Mutationnovelc.983G>Ap.Arg328Glnp.R328QQ9UKZ1protein_codingtolerated(0.2)benign(0.175)TCGA-AA-A00N-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
CNOT11SNVMissense_Mutationrs778787740c.599C>Tp.Thr200Metp.T200MQ9UKZ1protein_codingdeleterious(0.05)probably_damaging(0.996)TCGA-D5-6529-01Colorectumcolon adenocarcinomaMale>=65I/IIChemotherapyoxaliplatinum+SD
CNOT11SNVMissense_Mutationrs775090253c.811N>Ap.Gly271Argp.G271RQ9UKZ1protein_codingdeleterious(0.02)probably_damaging(0.999)TCGA-D5-6540-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
CNOT11SNVMissense_Mutationc.644C>Ap.Ser215Tyrp.S215YQ9UKZ1protein_codingdeleterious(0.02)benign(0.34)TCGA-DM-A0XF-01Colorectumcolon adenocarcinomaFemale>=65III/IVChemotherapymayoCR
CNOT11SNVMissense_Mutationnovelc.1348C>Tp.Arg450Cysp.R450CQ9UKZ1protein_codingdeleterious(0)probably_damaging(1)TCGA-G4-6304-01Colorectumcolon adenocarcinomaFemale>=65I/IIChemotherapyfluorouracilPD
CNOT11SNVMissense_Mutationrs750783059c.655N>Gp.Ser219Glyp.S219GQ9UKZ1protein_codingtolerated(0.13)probably_damaging(0.952)TCGA-G4-6320-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapyoxaliplatinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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