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Gene: CNOT11 |
Gene summary for CNOT11 |
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Gene information | Species | Human | Gene symbol | CNOT11 | Gene ID | 55571 |
Gene name | CCR4-NOT transcription complex subunit 11 | |
Gene Alias | C2orf29 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9UKZ1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55571 | CNOT11 | LZE2T | Human | Esophagus | ESCC | 2.50e-02 | 3.72e-01 | 0.082 |
55571 | CNOT11 | LZE7T | Human | Esophagus | ESCC | 9.44e-04 | 1.52e-01 | 0.0667 |
55571 | CNOT11 | LZE24T | Human | Esophagus | ESCC | 2.12e-04 | 1.96e-01 | 0.0596 |
55571 | CNOT11 | P2T-E | Human | Esophagus | ESCC | 1.39e-23 | 4.21e-01 | 0.1177 |
55571 | CNOT11 | P4T-E | Human | Esophagus | ESCC | 1.82e-10 | 3.67e-01 | 0.1323 |
55571 | CNOT11 | P5T-E | Human | Esophagus | ESCC | 9.56e-15 | 3.17e-01 | 0.1327 |
55571 | CNOT11 | P8T-E | Human | Esophagus | ESCC | 7.43e-10 | 1.53e-01 | 0.0889 |
55571 | CNOT11 | P9T-E | Human | Esophagus | ESCC | 2.31e-09 | 2.90e-01 | 0.1131 |
55571 | CNOT11 | P10T-E | Human | Esophagus | ESCC | 3.98e-11 | 1.79e-01 | 0.116 |
55571 | CNOT11 | P11T-E | Human | Esophagus | ESCC | 1.57e-02 | 1.35e-01 | 0.1426 |
55571 | CNOT11 | P12T-E | Human | Esophagus | ESCC | 7.99e-11 | 1.88e-01 | 0.1122 |
55571 | CNOT11 | P15T-E | Human | Esophagus | ESCC | 1.33e-12 | 3.08e-01 | 0.1149 |
55571 | CNOT11 | P16T-E | Human | Esophagus | ESCC | 4.73e-07 | 6.66e-02 | 0.1153 |
55571 | CNOT11 | P20T-E | Human | Esophagus | ESCC | 8.09e-07 | 1.22e-01 | 0.1124 |
55571 | CNOT11 | P21T-E | Human | Esophagus | ESCC | 9.02e-20 | 3.45e-01 | 0.1617 |
55571 | CNOT11 | P22T-E | Human | Esophagus | ESCC | 3.33e-10 | 1.22e-01 | 0.1236 |
55571 | CNOT11 | P23T-E | Human | Esophagus | ESCC | 1.62e-16 | 4.66e-01 | 0.108 |
55571 | CNOT11 | P24T-E | Human | Esophagus | ESCC | 2.47e-07 | 1.84e-01 | 0.1287 |
55571 | CNOT11 | P26T-E | Human | Esophagus | ESCC | 1.26e-18 | 3.76e-01 | 0.1276 |
55571 | CNOT11 | P27T-E | Human | Esophagus | ESCC | 1.81e-09 | 1.58e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006401110 | Esophagus | ESCC | RNA catabolic process | 204/8552 | 278/18723 | 3.39e-21 | 5.66e-19 | 204 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:0006402110 | Esophagus | ESCC | mRNA catabolic process | 170/8552 | 232/18723 | 8.70e-18 | 8.00e-16 | 170 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
GO:003424914 | Esophagus | ESCC | negative regulation of cellular amide metabolic process | 144/8552 | 273/18723 | 1.08e-02 | 3.67e-02 | 144 |
GO:004427021 | Liver | HCC | cellular nitrogen compound catabolic process | 303/7958 | 451/18723 | 9.76e-27 | 3.64e-24 | 303 |
GO:004670021 | Liver | HCC | heterocycle catabolic process | 299/7958 | 445/18723 | 2.07e-26 | 7.29e-24 | 299 |
GO:190136121 | Liver | HCC | organic cyclic compound catabolic process | 325/7958 | 495/18723 | 6.52e-26 | 2.18e-23 | 325 |
GO:001943921 | Liver | HCC | aromatic compound catabolic process | 309/7958 | 467/18723 | 1.56e-25 | 4.94e-23 | 309 |
GO:000640121 | Liver | HCC | RNA catabolic process | 201/7958 | 278/18723 | 3.88e-24 | 1.02e-21 | 201 |
GO:003465521 | Liver | HCC | nucleobase-containing compound catabolic process | 273/7958 | 407/18723 | 4.84e-24 | 1.23e-21 | 273 |
GO:000640221 | Liver | HCC | mRNA catabolic process | 169/7958 | 232/18723 | 4.50e-21 | 6.96e-19 | 169 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:003424921 | Liver | HCC | negative regulation of cellular amide metabolic process | 144/7958 | 273/18723 | 3.80e-04 | 2.61e-03 | 144 |
GO:001714821 | Liver | HCC | negative regulation of translation | 129/7958 | 245/18723 | 8.14e-04 | 4.87e-03 | 129 |
GO:000640118 | Oral cavity | OSCC | RNA catabolic process | 184/7305 | 278/18723 | 2.71e-20 | 4.19e-18 | 184 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNOT11 | SNV | Missense_Mutation | novel | c.317C>T | p.Ser106Leu | p.S106L | Q9UKZ1 | protein_coding | tolerated(0.71) | benign(0.148) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
CNOT11 | SNV | Missense_Mutation | c.913N>A | p.Glu305Lys | p.E305K | Q9UKZ1 | protein_coding | tolerated(0.07) | benign(0.304) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CNOT11 | SNV | Missense_Mutation | novel | c.736G>A | p.Asp246Asn | p.D246N | Q9UKZ1 | protein_coding | deleterious(0.03) | probably_damaging(0.989) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CNOT11 | SNV | Missense_Mutation | c.76N>T | p.Ala26Ser | p.A26S | Q9UKZ1 | protein_coding | deleterious_low_confidence(0) | benign(0.001) | TCGA-A6-5659-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CNOT11 | SNV | Missense_Mutation | novel | c.983G>A | p.Arg328Gln | p.R328Q | Q9UKZ1 | protein_coding | tolerated(0.2) | benign(0.175) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CNOT11 | SNV | Missense_Mutation | rs778787740 | c.599C>T | p.Thr200Met | p.T200M | Q9UKZ1 | protein_coding | deleterious(0.05) | probably_damaging(0.996) | TCGA-D5-6529-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatinum+ | SD |
CNOT11 | SNV | Missense_Mutation | rs775090253 | c.811N>A | p.Gly271Arg | p.G271R | Q9UKZ1 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-D5-6540-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CNOT11 | SNV | Missense_Mutation | c.644C>A | p.Ser215Tyr | p.S215Y | Q9UKZ1 | protein_coding | deleterious(0.02) | benign(0.34) | TCGA-DM-A0XF-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | mayo | CR | |
CNOT11 | SNV | Missense_Mutation | novel | c.1348C>T | p.Arg450Cys | p.R450C | Q9UKZ1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD |
CNOT11 | SNV | Missense_Mutation | rs750783059 | c.655N>G | p.Ser219Gly | p.S219G | Q9UKZ1 | protein_coding | tolerated(0.13) | probably_damaging(0.952) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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