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Gene: CNNM3 |
Gene summary for CNNM3 |
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Gene information | Species | Human | Gene symbol | CNNM3 | Gene ID | 26505 |
Gene name | cyclin and CBS domain divalent metal cation transport mediator 3 | |
Gene Alias | ACDP3 | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8NE01 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26505 | CNNM3 | HCC1_Meng | Human | Liver | HCC | 2.73e-22 | 2.75e-02 | 0.0246 |
26505 | CNNM3 | HCC2_Meng | Human | Liver | HCC | 3.22e-02 | 4.15e-02 | 0.0107 |
26505 | CNNM3 | HCC1 | Human | Liver | HCC | 2.48e-07 | 2.50e+00 | 0.5336 |
26505 | CNNM3 | HCC2 | Human | Liver | HCC | 4.50e-16 | 3.19e+00 | 0.5341 |
26505 | CNNM3 | S014 | Human | Liver | HCC | 2.02e-08 | 3.22e-01 | 0.2254 |
26505 | CNNM3 | S015 | Human | Liver | HCC | 3.14e-14 | 5.54e-01 | 0.2375 |
26505 | CNNM3 | S016 | Human | Liver | HCC | 7.69e-11 | 3.32e-01 | 0.2243 |
26505 | CNNM3 | S028 | Human | Liver | HCC | 1.02e-05 | 2.90e-01 | 0.2503 |
26505 | CNNM3 | S029 | Human | Liver | HCC | 8.40e-05 | 1.61e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CNNM3 | SNV | Missense_Mutation | novel | c.1034N>A | p.Gly345Asp | p.G345D | Q8NE01 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A5J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CNNM3 | SNV | Missense_Mutation | c.1327G>C | p.Glu443Gln | p.E443Q | Q8NE01 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-EW-A1IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD | |
CNNM3 | insertion | Nonsense_Mutation | novel | c.1964_1965insTTAATTTTTTTTTTTTATTTTGAGACGGTCTTG | p.Ala655_Gln656insTer | p.A655_Q656ins* | Q8NE01 | protein_coding | TCGA-A8-A07P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | ||
CNNM3 | insertion | Frame_Shift_Ins | novel | c.1649_1650insTATTGGCCAGGCTGGTCTCCAACTCCTGACT | p.Gln550HisfsTer28 | p.Q550Hfs*28 | Q8NE01 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CNNM3 | SNV | Missense_Mutation | c.1526N>G | p.Asp509Gly | p.D509G | Q8NE01 | protein_coding | deleterious(0.02) | benign(0.001) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
CNNM3 | SNV | Missense_Mutation | c.1126T>G | p.Cys376Gly | p.C376G | Q8NE01 | protein_coding | deleterious(0.01) | benign(0.186) | TCGA-QG-A5YV-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
CNNM3 | SNV | Missense_Mutation | rs754286149 | c.1888N>A | p.Val630Met | p.V630M | Q8NE01 | protein_coding | deleterious(0) | possibly_damaging(0.791) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CNNM3 | SNV | Missense_Mutation | rs770397651 | c.1925N>T | p.Thr642Met | p.T642M | Q8NE01 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CNNM3 | SNV | Missense_Mutation | c.1711N>A | p.Gly571Arg | p.G571R | Q8NE01 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
CNNM3 | SNV | Missense_Mutation | c.1478N>T | p.Ser493Leu | p.S493L | Q8NE01 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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