Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CNFN

Gene summary for CNFN

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CNFN

Gene ID

84518

Gene namecornifelin
Gene AliasPLAC8L2
Cytomap19q13.2
Gene Typeprotein-coding
GO ID

GO:0007275

UniProtAcc

Q9BYD5


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
84518CNFNGSM4909281HumanBreastIDC9.99e-112.30e-010.21
84518CNFNGSM4909287HumanBreastIDC3.93e-145.40e-010.2057
84518CNFNGSM4909298HumanBreastIDC9.79e-071.71e-010.1551
84518CNFNGSM4909299HumanBreastIDC4.84e-082.46e-010.035
84518CNFNGSM4909304HumanBreastIDC2.48e-366.20e-010.1636
84518CNFNGSM4909315HumanBreastIDC2.27e-093.92e-010.21
84518CNFNGSM4909316HumanBreastIDC3.64e-033.84e-010.21
84518CNFNGSM4909319HumanBreastIDC2.06e-03-3.90e-020.1563
84518CNFNDCIS2HumanBreastDCIS1.22e-241.47e-020.0085
84518CNFNLZE4THumanEsophagusESCC1.27e-075.23e-020.0811
84518CNFNLZE5THumanEsophagusESCC1.02e-039.49e-010.0514
84518CNFNLZE7THumanEsophagusESCC1.17e-032.01e-010.0667
84518CNFNLZE24THumanEsophagusESCC3.04e-081.86e-010.0596
84518CNFNP1T-EHumanEsophagusESCC4.67e-051.98e-010.0875
84518CNFNP2T-EHumanEsophagusESCC4.86e-088.56e-020.1177
84518CNFNP4T-EHumanEsophagusESCC1.43e-133.04e-010.1323
84518CNFNP5T-EHumanEsophagusESCC2.15e-131.20e-010.1327
84518CNFNP8T-EHumanEsophagusESCC2.72e-451.04e+000.0889
84518CNFNP9T-EHumanEsophagusESCC1.08e-082.57e-010.1131
84518CNFNP10T-EHumanEsophagusESCC8.38e-801.54e+000.116
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
BreastThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.IDC: Invasive ductal carcinoma
DCIS: Ductal carcinoma in situ
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:000854412BreastIDCepidermis development41/1434324/187231.03e-031.14e-0241
GO:000991312BreastIDCepidermal cell differentiation28/1434202/187231.62e-031.60e-0228
GO:00302161BreastIDCkeratinocyte differentiation21/1434139/187232.06e-031.95e-0221
GO:00435883BreastIDCskin development33/1434263/187233.46e-032.87e-0233
GO:000854422BreastDCISepidermis development40/1390324/187231.05e-031.16e-0240
GO:000991322BreastDCISepidermal cell differentiation27/1390202/187232.11e-031.97e-0227
GO:00302162BreastDCISkeratinocyte differentiation20/1390139/187233.24e-032.74e-0220
GO:004358812BreastDCISskin development31/1390263/187237.15e-034.85e-0231
GO:00435888EsophagusESCCskin development163/8552263/187236.48e-081.14e-06163
GO:000854410EsophagusESCCepidermis development193/8552324/187232.87e-074.19e-06193
GO:000991310EsophagusESCCepidermal cell differentiation122/8552202/187231.69e-051.51e-04122
GO:00302167EsophagusESCCkeratinocyte differentiation86/8552139/187238.53e-056.19e-0486
GO:00435887Oral cavityOSCCskin development143/7305263/187232.77e-074.27e-06143
GO:00085449Oral cavityOSCCepidermis development171/7305324/187232.89e-074.43e-06171
GO:00302166Oral cavityOSCCkeratinocyte differentiation81/7305139/187233.16e-063.81e-0581
GO:00099139Oral cavityOSCCepidermal cell differentiation109/7305202/187231.08e-051.14e-04109
GO:000854416Oral cavityLPepidermis development112/4623324/187233.81e-055.61e-04112
GO:004358816Oral cavityLPskin development93/4623263/187236.47e-058.70e-0493
GO:003021613Oral cavityLPkeratinocyte differentiation51/4623139/187231.05e-038.84e-0351
GO:000991315Oral cavityLPepidermal cell differentiation69/4623202/187231.53e-031.19e-0269
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CNFNdeletionFrame_Shift_Delnovelc.39delNp.Thr14ProfsTer95p.T14Pfs*95Q9BYD5protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
CNFNSNVMissense_Mutationc.45N>Ap.Ser15Argp.S15RQ9BYD5protein_codingtolerated(0.25)benign(0)TCGA-AA-3492-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
CNFNSNVMissense_Mutationnovelc.100N>Ap.Asp34Asnp.D34NQ9BYD5protein_codingdeleterious(0.01)possibly_damaging(0.822)TCGA-EI-6917-01Colorectumrectum adenocarcinomaMale<65III/IVChemotherapy5fluorouracil+oxaciplatina+l-folinianSD
CNFNSNVMissense_Mutationnovelc.292N>Tp.Pro98Serp.P98SQ9BYD5protein_codingdeleterious(0.01)probably_damaging(0.928)TCGA-D1-A2G0-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
CNFNSNVMissense_Mutationnovelc.321N>Cp.Glu107Aspp.E107DQ9BYD5protein_codingdeleterious(0.03)probably_damaging(0.987)TCGA-EY-A1GD-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
CNFNSNVMissense_Mutationc.271N>Tp.Ala91Serp.A91SQ9BYD5protein_codingtolerated(0.06)possibly_damaging(0.75)TCGA-60-2698-01Lunglung squamous cell carcinomaMale<65I/IIChemotherapymithramycinPD
CNFNSNVMissense_Mutationnovelc.86C>Tp.Thr29Metp.T29MQ9BYD5protein_codingtolerated(0.22)benign(0.018)TCGA-63-A5MM-01Lunglung squamous cell carcinomaFemale>=65I/IIChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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