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Gene: CMTM4 |
Gene summary for CMTM4 |
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Gene information | Species | Human | Gene symbol | CMTM4 | Gene ID | 146223 |
Gene name | CKLF like MARVEL transmembrane domain containing 4 | |
Gene Alias | CKLFSF4 | |
Cytomap | 16q21-q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8IZR5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
146223 | CMTM4 | CCI_1 | Human | Cervix | CC | 2.78e-04 | 4.37e-01 | 0.528 |
146223 | CMTM4 | CCI_2 | Human | Cervix | CC | 3.31e-09 | 7.06e-01 | 0.5249 |
146223 | CMTM4 | CCI_3 | Human | Cervix | CC | 2.99e-07 | 5.40e-01 | 0.516 |
146223 | CMTM4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.05e-06 | -3.84e-01 | 0.0155 |
146223 | CMTM4 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.81e-18 | 7.96e-01 | -0.1954 |
146223 | CMTM4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.59e-09 | -4.75e-01 | 0.3005 |
146223 | CMTM4 | F007 | Human | Colorectum | FAP | 6.96e-09 | -4.87e-01 | 0.1176 |
146223 | CMTM4 | A001-C-207 | Human | Colorectum | FAP | 1.36e-07 | -3.42e-01 | 0.1278 |
146223 | CMTM4 | A015-C-203 | Human | Colorectum | FAP | 1.65e-31 | -5.38e-01 | -0.1294 |
146223 | CMTM4 | A015-C-204 | Human | Colorectum | FAP | 1.43e-13 | -4.62e-01 | -0.0228 |
146223 | CMTM4 | A014-C-040 | Human | Colorectum | FAP | 3.33e-07 | -5.54e-01 | -0.1184 |
146223 | CMTM4 | A002-C-201 | Human | Colorectum | FAP | 1.00e-17 | -4.17e-01 | 0.0324 |
146223 | CMTM4 | A002-C-203 | Human | Colorectum | FAP | 6.89e-06 | -2.76e-01 | 0.2786 |
146223 | CMTM4 | A001-C-119 | Human | Colorectum | FAP | 1.73e-10 | -4.88e-01 | -0.1557 |
146223 | CMTM4 | A001-C-108 | Human | Colorectum | FAP | 1.89e-22 | -5.23e-01 | -0.0272 |
146223 | CMTM4 | A002-C-205 | Human | Colorectum | FAP | 1.55e-28 | -5.59e-01 | -0.1236 |
146223 | CMTM4 | A001-C-104 | Human | Colorectum | FAP | 4.80e-07 | -3.77e-01 | 0.0184 |
146223 | CMTM4 | A015-C-005 | Human | Colorectum | FAP | 1.64e-08 | -3.77e-01 | -0.0336 |
146223 | CMTM4 | A015-C-006 | Human | Colorectum | FAP | 9.54e-19 | -5.32e-01 | -0.0994 |
146223 | CMTM4 | A015-C-106 | Human | Colorectum | FAP | 9.97e-14 | -4.40e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CMTM4 | SNV | Missense_Mutation | c.394C>A | p.Leu132Ile | p.L132I | Q8IZR5 | protein_coding | tolerated(0.13) | benign(0.089) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
CMTM4 | SNV | Missense_Mutation | rs374620860 | c.643N>A | p.Val215Ile | p.V215I | Q8IZR5 | protein_coding | tolerated_low_confidence(0.25) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CMTM4 | SNV | Missense_Mutation | rs764170070 | c.388N>A | p.Ala130Thr | p.A130T | Q8IZR5 | protein_coding | tolerated(0.86) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CMTM4 | SNV | Missense_Mutation | c.657N>T | p.Lys219Asn | p.K219N | Q8IZR5 | protein_coding | tolerated_low_confidence(0.22) | benign(0.011) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CMTM4 | SNV | Missense_Mutation | rs773632428 | c.613C>T | p.Arg205Cys | p.R205C | Q8IZR5 | protein_coding | deleterious(0.01) | benign(0.026) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CMTM4 | SNV | Missense_Mutation | novel | c.425N>T | p.Ala142Val | p.A142V | Q8IZR5 | protein_coding | tolerated(0.09) | benign(0.341) | TCGA-E6-A2P8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CMTM4 | SNV | Missense_Mutation | novel | c.577N>A | p.Glu193Lys | p.E193K | Q8IZR5 | protein_coding | tolerated(0.13) | possibly_damaging(0.551) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CMTM4 | SNV | Missense_Mutation | rs772354497 | c.614G>A | p.Arg205His | p.R205H | Q8IZR5 | protein_coding | deleterious(0.02) | benign(0.026) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
CMTM4 | insertion | Frame_Shift_Ins | novel | c.628_629insT | p.Ser210PhefsTer31 | p.S210Ffs*31 | Q8IZR5 | protein_coding | TCGA-BG-A0VZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR | ||
CMTM4 | SNV | Missense_Mutation | novel | c.491N>T | p.Tyr164Phe | p.Y164F | Q8IZR5 | protein_coding | tolerated(1) | possibly_damaging(0.793) | TCGA-DD-AAC8-01 | Liver | liver hepatocellular carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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