Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CMKLR1

Gene summary for CMKLR1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CMKLR1

Gene ID

1240

Gene namechemerin chemokine-like receptor 1
Gene AliasCHEMERINR
Cytomap12q23.3
Gene Typeprotein-coding
GO ID

GO:0001501

UniProtAcc

Q99788


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1240CMKLR1ATC12HumanThyroidATC1.19e-103.72e-010.34
1240CMKLR1ATC2HumanThyroidATC7.49e-035.69e-010.34
1240CMKLR1ATC4HumanThyroidATC6.15e-144.78e-010.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005109022ThyroidATCregulation of DNA-binding transcription factor activity190/6293440/187231.49e-051.39e-04190
GO:005092123ThyroidATCpositive regulation of chemotaxis70/6293141/187235.77e-054.43e-0470
GO:004544423ThyroidATCfat cell differentiation105/6293229/187237.42e-055.62e-04105
GO:003210324ThyroidATCpositive regulation of response to external stimulus178/6293427/187232.61e-041.67e-03178
GO:000268719ThyroidATCpositive regulation of leukocyte migration65/6293135/187233.18e-041.99e-0365
GO:010610621ThyroidATCcold-induced thermogenesis68/6293144/187234.70e-042.76e-0368
GO:012016121ThyroidATCregulation of cold-induced thermogenesis68/6293144/187234.70e-042.76e-0368
GO:00509206ThyroidATCregulation of chemotaxis99/6293223/187234.91e-042.86e-0399
GO:000269023ThyroidATCpositive regulation of leukocyte chemotaxis47/629394/187237.32e-044.11e-0347
GO:199084521ThyroidATCadaptive thermogenesis71/6293157/187231.59e-037.99e-0371
GO:000268818ThyroidATCregulation of leukocyte chemotaxis57/6293122/187231.77e-038.71e-0357
GO:000268519ThyroidATCregulation of leukocyte migration90/6293210/187233.11e-031.40e-0290
GO:00508483ThyroidATCregulation of calcium-mediated signaling36/629373/187233.91e-031.70e-0236
GO:00434333ThyroidATCnegative regulation of DNA-binding transcription factor activity79/6293185/187235.96e-032.40e-0279
GO:01201625ThyroidATCpositive regulation of cold-induced thermogenesis45/629397/187235.97e-032.40e-0245
GO:007167516ThyroidATCregulation of mononuclear cell migration52/6293115/187236.24e-032.50e-0252
GO:004559822ThyroidATCregulation of fat cell differentiation61/6293139/187237.28e-032.86e-0261
GO:004560023ThyroidATCpositive regulation of fat cell differentiation32/629366/187238.63e-033.28e-0232
GO:000165912ThyroidATCtemperature homeostasis73/6293174/187231.29e-024.51e-0273
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINBreastDCIS
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINBreastIDC
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINCervixCC
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINCRCAD
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINCRCSER
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINHNSCCOSCC
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINLiverHealthy
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINLungAAH
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINTHCAADJ
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINTHCACancer
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINTHCAPrecancer
RARRES2CMKLR1RARRES2_CMKLR1CHEMERINTHCAPTC
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CMKLR1SNVMissense_Mutationc.1069T>Ap.Ser357Thrp.S357TQ99788protein_codingtolerated(0.09)possibly_damaging(0.471)TCGA-A8-A06X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CMKLR1SNVMissense_Mutationc.989T>Ap.Leu330Hisp.L330HQ99788protein_codingdeleterious(0)possibly_damaging(0.75)TCGA-AR-A251-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydoxorubicinSD
CMKLR1SNVMissense_Mutationrs767125122c.1040A>Cp.Tyr347Serp.Y347SQ99788protein_codingtolerated(0.28)benign(0.001)TCGA-B6-A0IB-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
CMKLR1SNVMissense_Mutationc.914C>Tp.Ala305Valp.A305VQ99788protein_codingdeleterious(0)probably_damaging(0.971)TCGA-GM-A2DD-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyfluorouracilCR
CMKLR1SNVMissense_Mutationnovelc.885N>Ap.Ser295Argp.S295RQ99788protein_codingtolerated(0.49)benign(0.026)TCGA-PL-A8LZ-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapypaclitaxelSD
CMKLR1SNVMissense_Mutationc.978N>Gp.Phe326Leup.F326LQ99788protein_codingtolerated(0.37)benign(0.062)TCGA-C5-A1ML-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
CMKLR1SNVMissense_Mutationc.1077N>Ap.Met359Ilep.M359IQ99788protein_codingtolerated(0.2)benign(0)TCGA-EA-A43B-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
CMKLR1SNVMissense_Mutationc.868C>Tp.Pro290Serp.P290SQ99788protein_codingtolerated(0.26)benign(0.18)TCGA-FU-A2QG-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CMKLR1SNVMissense_Mutationrs775282959c.751C>Tp.Arg251Cysp.R251CQ99788protein_codingdeleterious(0)probably_damaging(0.994)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CMKLR1SNVMissense_Mutationnovelc.1012C>Gp.Leu338Valp.L338VQ99788protein_codingdeleterious(0.02)possibly_damaging(0.54)TCGA-VS-A8EI-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
1240CMKLR1G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOMEagonist178100364
1240CMKLR1G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOMEagonist178100428
1240CMKLR1G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOMECCX832
1240CMKLR1G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOMEagonist135651892
1240CMKLR1G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOMEagonist354702257
1240CMKLR1G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOMEagonist135651571
1240CMKLR1G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOMEantagonist354702254
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