Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CMIP

Gene summary for CMIP

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CMIP

Gene ID

80790

Gene namec-Maf inducing protein
Gene AliasTCMIP
Cytomap16q23.2-q23.3
Gene Typeprotein-coding
GO ID

GO:0001701

UniProtAcc

Q8IY22


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
80790CMIPCA_HPV_2HumanCervixCC4.38e-063.38e-010.0391
80790CMIPN_HPV_2HumanCervixN_HPV6.90e-031.64e-01-0.0131
80790CMIPCCI_1HumanCervixCC4.30e-242.72e+000.528
80790CMIPCCI_2HumanCervixCC4.92e-142.31e+000.5249
80790CMIPCCI_3HumanCervixCC6.46e-282.07e+000.516
80790CMIPCCII_1HumanCervixCC3.77e-054.20e-010.3249
80790CMIPsample3HumanCervixCC3.10e-133.52e-010.1387
80790CMIPT3HumanCervixCC3.04e-083.47e-010.1389
80790CMIPHTA11_1938_2000001011HumanColorectumAD7.03e-044.58e-01-0.0811
80790CMIPHTA11_78_2000001011HumanColorectumAD1.14e-024.48e-01-0.1088
80790CMIPHTA11_347_2000001011HumanColorectumAD2.51e-136.51e-01-0.1954
80790CMIPHTA11_411_2000001011HumanColorectumSER1.69e-048.33e-01-0.2602
80790CMIPHTA11_2112_2000001011HumanColorectumSER2.02e-026.28e-01-0.2196
80790CMIPHTA11_696_2000001011HumanColorectumAD5.44e-085.72e-01-0.1464
80790CMIPHTA11_866_2000001011HumanColorectumAD3.30e-033.87e-01-0.1001
80790CMIPHTA11_99999965062_69753HumanColorectumMSI-H4.37e-058.21e-010.3487
80790CMIPHTA11_99999965104_69814HumanColorectumMSS4.91e-087.04e-010.281
80790CMIPF007HumanColorectumFAP2.82e-04-2.25e-010.1176
80790CMIPA001-C-207HumanColorectumFAP5.67e-041.80e-020.1278
80790CMIPA015-C-203HumanColorectumFAP1.17e-28-3.42e-01-0.1294
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00017018CervixCCin utero embryonic development71/2311367/187237.21e-051.00e-0371
GO:0001701ColorectumADin utero embryonic development110/3918367/187232.36e-054.62e-04110
GO:00017011ColorectumSERin utero embryonic development77/2897367/187232.77e-032.48e-0277
GO:00017012ColorectumMSSin utero embryonic development99/3467367/187233.71e-057.10e-0499
GO:00017013ColorectumFAPin utero embryonic development81/2622367/187231.58e-054.10e-0481
GO:00017014ColorectumCRCin utero embryonic development57/2078367/187235.54e-034.19e-0257
GO:00017019EndometriumAEHin utero embryonic development73/2100367/187237.18e-072.63e-0573
GO:000170114EndometriumEECin utero embryonic development75/2168367/187235.86e-072.16e-0575
GO:000170119EsophagusESCCin utero embryonic development243/8552367/187231.00e-156.86e-14243
GO:00017015LiverCirrhoticin utero embryonic development134/4634367/187232.78e-076.86e-06134
GO:000170111LiverHCCin utero embryonic development204/7958367/187232.44e-074.30e-06204
GO:00017016LungIACin utero embryonic development68/2061367/187231.12e-053.45e-0468
GO:000170112LungAISin utero embryonic development59/1849367/187231.20e-042.75e-0359
GO:000170121LungAAHin utero embryonic development24/613367/187231.09e-033.25e-0224
GO:000170131LungMIACin utero embryonic development33/967367/187231.44e-032.54e-0233
GO:000170116Oral cavityOSCCin utero embryonic development207/7305367/187237.92e-122.95e-10207
GO:000170117Oral cavityLPin utero embryonic development142/4623367/187231.48e-096.75e-08142
GO:000170123Oral cavityEOLPin utero embryonic development72/2218367/187231.02e-051.83e-0472
GO:000170132Oral cavityNEOLPin utero embryonic development76/2005367/187231.11e-085.44e-0776
GO:000170110ProstateBPHin utero embryonic development104/3107367/187239.17e-093.10e-07104
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CMIPSNVMissense_Mutationc.2110C>Tp.Arg704Trpp.R704WQ8IY22protein_codingdeleterious(0.01)possibly_damaging(0.841)TCGA-C8-A12T-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
CMIPSNVMissense_Mutationc.1975N>Tp.Gly659Cysp.G659CQ8IY22protein_codingdeleterious(0)probably_damaging(0.999)TCGA-E2-A1IK-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
CMIPSNVMissense_Mutationc.203C>Tp.Pro68Leup.P68LQ8IY22protein_codingdeleterious(0.02)benign(0.007)TCGA-EK-A3GK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CMIPSNVMissense_Mutationnovelc.1984G>Ap.Gly662Argp.G662RQ8IY22protein_codingdeleterious(0.03)probably_damaging(0.997)TCGA-VS-A8QM-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
CMIPSNVMissense_Mutationc.1187N>Ap.Val396Aspp.V396DQ8IY22protein_codingdeleterious_low_confidence(0)benign(0.125)TCGA-AA-3492-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
CMIPSNVMissense_Mutationc.1654N>Tp.Gly552Cysp.G552CQ8IY22protein_codingdeleterious(0.01)probably_damaging(0.998)TCGA-AA-3502-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
CMIPSNVMissense_Mutationc.688N>Ap.Ala230Thrp.A230TQ8IY22protein_codingtolerated(0.07)probably_damaging(0.981)TCGA-AZ-4313-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
CMIPSNVMissense_Mutationc.635C>Tp.Ser212Leup.S212LQ8IY22protein_codingtolerated(0.18)benign(0.057)TCGA-CK-4951-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
CMIPSNVMissense_Mutationc.2276N>Cp.Leu759Prop.L759PQ8IY22protein_codingdeleterious(0)probably_damaging(0.996)TCGA-CM-5861-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownPD
CMIPSNVMissense_Mutationc.1114C>Tp.Arg372Cysp.R372CQ8IY22protein_codingdeleterious_low_confidence(0)probably_damaging(0.982)TCGA-D5-6930-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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