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Gene: CLRN3 |
Gene summary for CLRN3 |
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Gene information | Species | Human | Gene symbol | CLRN3 | Gene ID | 119467 |
Gene name | clarin 3 | |
Gene Alias | TMEM12 | |
Cytomap | 10q26.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NCR9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
119467 | CLRN3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.39e-02 | 3.89e-01 | -0.0811 |
119467 | CLRN3 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.14e-22 | 7.06e-01 | -0.1954 |
119467 | CLRN3 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.89e-07 | 4.74e-01 | -0.1526 |
119467 | CLRN3 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.77e-11 | 4.85e-01 | -0.1464 |
119467 | CLRN3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 8.99e-07 | 4.55e-01 | -0.059 |
119467 | CLRN3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.23e-03 | 5.62e-01 | -0.2061 |
119467 | CLRN3 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.69e-02 | 4.00e-01 | -0.0842 |
119467 | CLRN3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.28e-18 | 7.70e-01 | 0.294 |
119467 | CLRN3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.70e-04 | 9.10e-01 | 0.3487 |
119467 | CLRN3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.65e-13 | 6.53e-01 | 0.3859 |
119467 | CLRN3 | A015-C-203 | Human | Colorectum | FAP | 1.29e-02 | -8.23e-02 | -0.1294 |
119467 | CLRN3 | A015-C-104 | Human | Colorectum | FAP | 8.61e-04 | -1.22e-01 | -0.1899 |
119467 | CLRN3 | A002-C-116 | Human | Colorectum | FAP | 1.86e-04 | -1.41e-01 | -0.0452 |
119467 | CLRN3 | F034 | Human | Colorectum | FAP | 4.65e-04 | -1.50e-01 | -0.0665 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLRN3 | SNV | Missense_Mutation | rs367866010 | c.15N>T | p.Lys5Asn | p.K5N | Q8NCR9 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLRN3 | SNV | Missense_Mutation | c.517A>G | p.Thr173Ala | p.T173A | Q8NCR9 | protein_coding | tolerated(0.54) | benign(0) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLRN3 | SNV | Missense_Mutation | c.154A>G | p.Thr52Ala | p.T52A | Q8NCR9 | protein_coding | tolerated(0.09) | benign(0.028) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CLRN3 | SNV | Missense_Mutation | c.667G>A | p.Gly223Arg | p.G223R | Q8NCR9 | protein_coding | deleterious(0.02) | probably_damaging(0.993) | TCGA-EW-A2FR-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | epirubicin | SD | |
CLRN3 | SNV | Missense_Mutation | novel | c.551N>C | p.Ile184Thr | p.I184T | Q8NCR9 | protein_coding | tolerated(0.17) | benign(0.006) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CLRN3 | SNV | Missense_Mutation | rs371220164 | c.623N>A | p.Arg208Gln | p.R208Q | Q8NCR9 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
CLRN3 | SNV | Missense_Mutation | c.221N>G | p.Lys74Arg | p.K74R | Q8NCR9 | protein_coding | tolerated(0.51) | benign(0.023) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CLRN3 | SNV | Missense_Mutation | rs371220164 | c.623N>A | p.Arg208Gln | p.R208Q | Q8NCR9 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CLRN3 | SNV | Missense_Mutation | c.52N>A | p.Leu18Ile | p.L18I | Q8NCR9 | protein_coding | tolerated(0.35) | benign(0.187) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
CLRN3 | SNV | Missense_Mutation | novel | c.251N>A | p.Ser84Tyr | p.S84Y | Q8NCR9 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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