Tissue | Expression Dynamics | Abbreviation |
Breast | | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00083809 | Breast | Precancer | RNA splicing | 65/1080 | 434/18723 | 1.27e-12 | 2.53e-10 | 65 |
GO:00434849 | Breast | Precancer | regulation of RNA splicing | 34/1080 | 148/18723 | 2.66e-12 | 4.75e-10 | 34 |
GO:000838014 | Breast | IDC | RNA splicing | 73/1434 | 434/18723 | 1.27e-10 | 1.57e-08 | 73 |
GO:004348414 | Breast | IDC | regulation of RNA splicing | 36/1434 | 148/18723 | 3.32e-10 | 3.77e-08 | 36 |
GO:000838024 | Breast | DCIS | RNA splicing | 73/1390 | 434/18723 | 3.05e-11 | 5.08e-09 | 73 |
GO:004348424 | Breast | DCIS | regulation of RNA splicing | 36/1390 | 148/18723 | 1.40e-10 | 1.69e-08 | 36 |
GO:000838026 | Esophagus | HGIN | RNA splicing | 160/2587 | 434/18723 | 3.74e-34 | 1.12e-30 | 160 |
GO:004348427 | Esophagus | HGIN | regulation of RNA splicing | 59/2587 | 148/18723 | 3.61e-15 | 7.22e-13 | 59 |
GO:0008380111 | Esophagus | ESCC | RNA splicing | 336/8552 | 434/18723 | 1.74e-42 | 3.67e-39 | 336 |
GO:0043484111 | Esophagus | ESCC | regulation of RNA splicing | 116/8552 | 148/18723 | 3.18e-16 | 2.38e-14 | 116 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:001810710 | Esophagus | ESCC | peptidyl-threonine phosphorylation | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
GO:001821010 | Esophagus | ESCC | peptidyl-threonine modification | 70/8552 | 125/18723 | 1.29e-02 | 4.25e-02 | 70 |
GO:000838012 | Liver | Cirrhotic | RNA splicing | 229/4634 | 434/18723 | 9.13e-37 | 2.86e-33 | 229 |
GO:004348412 | Liver | Cirrhotic | regulation of RNA splicing | 85/4634 | 148/18723 | 2.03e-17 | 2.83e-15 | 85 |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLK1 | SNV | Missense_Mutation | | c.247N>C | p.Asn83His | p.N83H | P49759 | protein_coding | deleterious_low_confidence(0) | benign(0.047) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
CLK1 | SNV | Missense_Mutation | | c.246N>T | p.Glu82Asp | p.E82D | P49759 | protein_coding | deleterious_low_confidence(0.03) | benign(0.003) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD |
CLK1 | SNV | Missense_Mutation | | c.436T>G | p.Ser146Ala | p.S146A | P49759 | protein_coding | tolerated(0.05) | probably_damaging(0.977) | TCGA-AO-A1KS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CLK1 | SNV | Missense_Mutation | | c.937N>G | p.Gln313Glu | p.Q313E | P49759 | protein_coding | deleterious(0.01) | possibly_damaging(0.881) | TCGA-C8-A12T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLK1 | SNV | Missense_Mutation | | c.157G>C | p.Asp53His | p.D53H | P49759 | protein_coding | deleterious_low_confidence(0.02) | benign(0.024) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
CLK1 | SNV | Missense_Mutation | rs758189196 | c.1037N>T | p.Ala346Val | p.A346V | P49759 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CLK1 | SNV | Missense_Mutation | | c.605N>C | p.Arg202Thr | p.R202T | P49759 | protein_coding | deleterious(0.01) | possibly_damaging(0.58) | TCGA-FU-A3YQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CLK1 | SNV | Missense_Mutation | | c.737N>A | p.Arg246His | p.R246H | P49759 | protein_coding | tolerated(0.14) | benign(0.023) | TCGA-Q1-A5R3-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
CLK1 | SNV | Missense_Mutation | novel | c.552G>T | p.Glu184Asp | p.E184D | P49759 | protein_coding | tolerated(0.05) | benign(0.337) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CLK1 | SNV | Missense_Mutation | | c.974A>C | p.Lys325Thr | p.K325T | P49759 | protein_coding | deleterious(0) | possibly_damaging(0.793) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565795 | | |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565842 | | |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | | HARMINE | HARMINE | 22998443 |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565735 | | |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | inhibitor | 249565841 | | |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | | LEUCETTAMINE B | LEUCETTAMINE B | 22998443 |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | | NU-2058 | CHEMBL269881 | |
1195 | CLK1 | SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME, TYROSINE KINASE | | TG003 | | |