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Gene: CLCN7 |
Gene summary for CLCN7 |
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Gene information | Species | Human | Gene symbol | CLCN7 | Gene ID | 1186 |
Gene name | chloride voltage-gated channel 7 | |
Gene Alias | CLC-7 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P51798 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1186 | CLCN7 | LZE7T | Human | Esophagus | ESCC | 1.12e-09 | 2.30e-01 | 0.0667 |
1186 | CLCN7 | LZE20T | Human | Esophagus | ESCC | 3.71e-02 | 1.32e-01 | 0.0662 |
1186 | CLCN7 | LZE21D1 | Human | Esophagus | HGIN | 2.68e-02 | 1.74e-01 | 0.0632 |
1186 | CLCN7 | LZE22T | Human | Esophagus | ESCC | 3.47e-10 | 3.35e-01 | 0.068 |
1186 | CLCN7 | LZE24T | Human | Esophagus | ESCC | 2.78e-12 | 2.25e-01 | 0.0596 |
1186 | CLCN7 | P1T-E | Human | Esophagus | ESCC | 2.48e-05 | 2.24e-01 | 0.0875 |
1186 | CLCN7 | P2T-E | Human | Esophagus | ESCC | 2.58e-16 | 3.88e-01 | 0.1177 |
1186 | CLCN7 | P4T-E | Human | Esophagus | ESCC | 5.49e-09 | 1.68e-01 | 0.1323 |
1186 | CLCN7 | P5T-E | Human | Esophagus | ESCC | 3.66e-05 | 6.95e-02 | 0.1327 |
1186 | CLCN7 | P8T-E | Human | Esophagus | ESCC | 1.11e-12 | 1.68e-01 | 0.0889 |
1186 | CLCN7 | P9T-E | Human | Esophagus | ESCC | 6.43e-05 | 8.15e-02 | 0.1131 |
1186 | CLCN7 | P10T-E | Human | Esophagus | ESCC | 5.31e-11 | 7.82e-02 | 0.116 |
1186 | CLCN7 | P11T-E | Human | Esophagus | ESCC | 3.31e-05 | 2.68e-01 | 0.1426 |
1186 | CLCN7 | P12T-E | Human | Esophagus | ESCC | 6.51e-22 | 3.84e-01 | 0.1122 |
1186 | CLCN7 | P15T-E | Human | Esophagus | ESCC | 3.85e-19 | 3.90e-01 | 0.1149 |
1186 | CLCN7 | P16T-E | Human | Esophagus | ESCC | 1.29e-10 | 1.18e-01 | 0.1153 |
1186 | CLCN7 | P17T-E | Human | Esophagus | ESCC | 2.97e-08 | 2.46e-01 | 0.1278 |
1186 | CLCN7 | P20T-E | Human | Esophagus | ESCC | 4.11e-09 | 9.87e-02 | 0.1124 |
1186 | CLCN7 | P21T-E | Human | Esophagus | ESCC | 9.38e-13 | 2.45e-01 | 0.1617 |
1186 | CLCN7 | P22T-E | Human | Esophagus | ESCC | 4.74e-16 | 1.48e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLCN7 | SNV | Missense_Mutation | c.930N>G | p.Phe310Leu | p.F310L | P51798 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CLCN7 | SNV | Missense_Mutation | novel | c.1739N>T | p.Gly580Val | p.G580V | P51798 | protein_coding | deleterious(0.03) | probably_damaging(0.981) | TCGA-AC-A3TN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
CLCN7 | SNV | Missense_Mutation | novel | c.272C>G | p.Ser91Cys | p.S91C | P51798 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLCN7 | deletion | Frame_Shift_Del | novel | c.1102delA | p.Met368TrpfsTer28 | p.M368Wfs*28 | P51798 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CLCN7 | deletion | Frame_Shift_Del | novel | c.388delT | p.Cys130AlafsTer53 | p.C130Afs*53 | P51798 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CLCN7 | SNV | Missense_Mutation | c.1225N>T | p.Arg409Trp | p.R409W | P51798 | protein_coding | tolerated(0.14) | probably_damaging(0.97) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CLCN7 | SNV | Missense_Mutation | novel | c.1966T>C | p.Ser656Pro | p.S656P | P51798 | protein_coding | tolerated(0.07) | possibly_damaging(0.756) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CLCN7 | SNV | Missense_Mutation | novel | c.211N>T | p.Pro71Ser | p.P71S | P51798 | protein_coding | tolerated(0.69) | benign(0) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLCN7 | SNV | Missense_Mutation | c.458G>A | p.Gly153Asp | p.G153D | P51798 | protein_coding | tolerated(0.3) | possibly_damaging(0.879) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CLCN7 | SNV | Missense_Mutation | c.2028G>T | p.Gln676His | p.Q676H | P51798 | protein_coding | tolerated(0.53) | benign(0.44) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1186 | CLCN7 | ION CHANNEL, DRUGGABLE GENOME, TRANSPORTER | blocker | 178100996 | ||
1186 | CLCN7 | ION CHANNEL, DRUGGABLE GENOME, TRANSPORTER | blocker | 178101087 | ||
1186 | CLCN7 | ION CHANNEL, DRUGGABLE GENOME, TRANSPORTER | blocker | 178101092 |
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