|
Gene: CLCN6 |
Gene summary for CLCN6 |
Gene summary. |
Gene information | Species | Human | Gene symbol | CLCN6 | Gene ID | 1185 |
Gene name | chloride voltage-gated channel 6 | |
Gene Alias | CLC-6 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P51797 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1185 | CLCN6 | LZE20T | Human | Esophagus | ESCC | 4.98e-02 | 9.16e-02 | 0.0662 |
1185 | CLCN6 | LZE24T | Human | Esophagus | ESCC | 5.13e-03 | 1.12e-01 | 0.0596 |
1185 | CLCN6 | P2T-E | Human | Esophagus | ESCC | 1.13e-04 | 1.29e-01 | 0.1177 |
1185 | CLCN6 | P4T-E | Human | Esophagus | ESCC | 2.20e-02 | 9.24e-02 | 0.1323 |
1185 | CLCN6 | P5T-E | Human | Esophagus | ESCC | 1.56e-09 | 7.07e-02 | 0.1327 |
1185 | CLCN6 | P8T-E | Human | Esophagus | ESCC | 5.69e-19 | 1.30e-01 | 0.0889 |
1185 | CLCN6 | P10T-E | Human | Esophagus | ESCC | 2.90e-10 | 2.28e-01 | 0.116 |
1185 | CLCN6 | P12T-E | Human | Esophagus | ESCC | 2.96e-10 | 1.55e-01 | 0.1122 |
1185 | CLCN6 | P15T-E | Human | Esophagus | ESCC | 5.83e-12 | 2.36e-01 | 0.1149 |
1185 | CLCN6 | P16T-E | Human | Esophagus | ESCC | 5.97e-07 | 8.33e-02 | 0.1153 |
1185 | CLCN6 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 2.66e-01 | 0.1662 |
1185 | CLCN6 | P20T-E | Human | Esophagus | ESCC | 8.24e-04 | 9.82e-02 | 0.1124 |
1185 | CLCN6 | P21T-E | Human | Esophagus | ESCC | 5.69e-07 | 1.98e-01 | 0.1617 |
1185 | CLCN6 | P22T-E | Human | Esophagus | ESCC | 5.02e-09 | 8.18e-02 | 0.1236 |
1185 | CLCN6 | P23T-E | Human | Esophagus | ESCC | 1.83e-07 | 1.76e-01 | 0.108 |
1185 | CLCN6 | P26T-E | Human | Esophagus | ESCC | 4.73e-06 | 9.76e-02 | 0.1276 |
1185 | CLCN6 | P27T-E | Human | Esophagus | ESCC | 1.36e-16 | 1.32e-01 | 0.1055 |
1185 | CLCN6 | P28T-E | Human | Esophagus | ESCC | 4.73e-03 | 1.08e-01 | 0.1149 |
1185 | CLCN6 | P30T-E | Human | Esophagus | ESCC | 7.79e-07 | 2.00e-01 | 0.137 |
1185 | CLCN6 | P31T-E | Human | Esophagus | ESCC | 1.36e-08 | 1.67e-01 | 0.1251 |
Page: 1 2 3 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003253520 | Esophagus | ESCC | regulation of cellular component size | 227/8552 | 383/18723 | 4.77e-08 | 8.60e-07 | 227 |
GO:00083619 | Esophagus | ESCC | regulation of cell size | 107/8552 | 181/18723 | 1.81e-04 | 1.16e-03 | 107 |
GO:000961216 | Esophagus | ESCC | response to mechanical stimulus | 124/8552 | 216/18723 | 3.30e-04 | 1.94e-03 | 124 |
GO:003253522 | Liver | HCC | regulation of cellular component size | 217/7958 | 383/18723 | 1.28e-08 | 3.14e-07 | 217 |
GO:00096124 | Liver | HCC | response to mechanical stimulus | 113/7958 | 216/18723 | 2.20e-03 | 1.10e-02 | 113 |
GO:00083614 | Liver | HCC | regulation of cell size | 95/7958 | 181/18723 | 4.15e-03 | 1.81e-02 | 95 |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CLCN6 | SNV | Missense_Mutation | novel | c.1685N>C | p.Met562Thr | p.M562T | P51797 | protein_coding | deleterious(0) | benign(0.331) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
CLCN6 | SNV | Missense_Mutation | c.1065N>G | p.Asn355Lys | p.N355K | P51797 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-A8-A08J-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
CLCN6 | SNV | Missense_Mutation | rs371954004 | c.1214C>T | p.Ser405Leu | p.S405L | P51797 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CLCN6 | SNV | Missense_Mutation | novel | c.1232N>G | p.Asp411Gly | p.D411G | P51797 | protein_coding | tolerated(0.48) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
CLCN6 | SNV | Missense_Mutation | rs371954004 | c.1214N>T | p.Ser405Leu | p.S405L | P51797 | protein_coding | tolerated(0.08) | benign(0.011) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
CLCN6 | SNV | Missense_Mutation | rs201010581 | c.772N>G | p.Ile258Val | p.I258V | P51797 | protein_coding | tolerated(0.66) | probably_damaging(0.997) | TCGA-E2-A14S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
CLCN6 | insertion | Frame_Shift_Ins | novel | c.2203_2204insCAGTCCATGAAGTCCTACCCATCCAGCGAGCTACGGAACATGT | p.Arg735ProfsTer42 | p.R735Pfs*42 | P51797 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
CLCN6 | insertion | Nonsense_Mutation | novel | c.1676_1677insATGAGCTGTAGGTCCTCCC | p.Thr560Ter | p.T560* | P51797 | protein_coding | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
CLCN6 | deletion | Frame_Shift_Del | novel | c.2161delT | p.Tyr721ThrfsTer19 | p.Y721Tfs*19 | P51797 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CLCN6 | SNV | Missense_Mutation | rs761839015 | c.806C>T | p.Ser269Leu | p.S269L | P51797 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1185 | CLCN6 | ION CHANNEL, DRUGGABLE GENOME | blocker | 178100996 | ||
1185 | CLCN6 | ION CHANNEL, DRUGGABLE GENOME | antipsychotics | 17976958 |
Page: 1 |