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Gene: CKAP5 |
Gene summary for CKAP5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CKAP5 | Gene ID | 9793 |
| Gene name | cytoskeleton associated protein 5 | |
| Gene Alias | CHTOG | |
| Cytomap | 11p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q14008 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9793 | CKAP5 | LZE2T | Human | Esophagus | ESCC | 5.05e-04 | 8.41e-01 | 0.082 |
| 9793 | CKAP5 | LZE4T | Human | Esophagus | ESCC | 2.12e-13 | 3.88e-01 | 0.0811 |
| 9793 | CKAP5 | LZE5T | Human | Esophagus | ESCC | 1.76e-03 | 3.10e-01 | 0.0514 |
| 9793 | CKAP5 | LZE7T | Human | Esophagus | ESCC | 3.52e-17 | 6.46e-01 | 0.0667 |
| 9793 | CKAP5 | LZE8T | Human | Esophagus | ESCC | 1.40e-10 | 2.54e-01 | 0.067 |
| 9793 | CKAP5 | LZE24T | Human | Esophagus | ESCC | 1.39e-12 | 3.74e-01 | 0.0596 |
| 9793 | CKAP5 | LZE6T | Human | Esophagus | ESCC | 3.95e-03 | 3.44e-01 | 0.0845 |
| 9793 | CKAP5 | P1T-E | Human | Esophagus | ESCC | 4.90e-04 | 2.25e-01 | 0.0875 |
| 9793 | CKAP5 | P2T-E | Human | Esophagus | ESCC | 1.92e-34 | 5.98e-01 | 0.1177 |
| 9793 | CKAP5 | P4T-E | Human | Esophagus | ESCC | 5.96e-12 | 4.55e-01 | 0.1323 |
| 9793 | CKAP5 | P5T-E | Human | Esophagus | ESCC | 3.43e-13 | 2.53e-01 | 0.1327 |
| 9793 | CKAP5 | P8T-E | Human | Esophagus | ESCC | 1.57e-18 | 3.56e-01 | 0.0889 |
| 9793 | CKAP5 | P9T-E | Human | Esophagus | ESCC | 4.56e-16 | 3.21e-01 | 0.1131 |
| 9793 | CKAP5 | P10T-E | Human | Esophagus | ESCC | 5.25e-19 | 3.65e-01 | 0.116 |
| 9793 | CKAP5 | P11T-E | Human | Esophagus | ESCC | 1.70e-05 | 3.75e-01 | 0.1426 |
| 9793 | CKAP5 | P12T-E | Human | Esophagus | ESCC | 2.00e-15 | 3.26e-01 | 0.1122 |
| 9793 | CKAP5 | P15T-E | Human | Esophagus | ESCC | 2.72e-12 | 4.51e-01 | 0.1149 |
| 9793 | CKAP5 | P16T-E | Human | Esophagus | ESCC | 6.18e-23 | 3.50e-01 | 0.1153 |
| 9793 | CKAP5 | P17T-E | Human | Esophagus | ESCC | 5.37e-11 | 5.93e-01 | 0.1278 |
| 9793 | CKAP5 | P20T-E | Human | Esophagus | ESCC | 4.60e-17 | 4.11e-01 | 0.1124 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
| GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
| GO:0043624 | Colorectum | AD | cellular protein complex disassembly | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
| GO:0051261 | Colorectum | AD | protein depolymerization | 39/3918 | 114/18723 | 6.74e-04 | 6.91e-03 | 39 |
| GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
| GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
| GO:00436241 | Colorectum | SER | cellular protein complex disassembly | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
| GO:00512611 | Colorectum | SER | protein depolymerization | 31/2897 | 114/18723 | 9.18e-04 | 1.11e-02 | 31 |
| GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
| GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
| GO:00329843 | Colorectum | MSI-H | protein-containing complex disassembly | 28/1319 | 224/18723 | 2.24e-03 | 3.01e-02 | 28 |
| GO:00224113 | Colorectum | MSI-H | cellular component disassembly | 47/1319 | 443/18723 | 3.26e-03 | 3.99e-02 | 47 |
| GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
| GO:00329844 | Colorectum | FAP | protein-containing complex disassembly | 54/2622 | 224/18723 | 3.37e-05 | 7.48e-04 | 54 |
| GO:00512612 | Colorectum | FAP | protein depolymerization | 26/2622 | 114/18723 | 7.36e-03 | 4.40e-02 | 26 |
| GO:00329845 | Colorectum | CRC | protein-containing complex disassembly | 46/2078 | 224/18723 | 2.61e-05 | 7.18e-04 | 46 |
| GO:00224115 | Colorectum | CRC | cellular component disassembly | 75/2078 | 443/18723 | 1.26e-04 | 2.42e-03 | 75 |
| GO:00512613 | Colorectum | CRC | protein depolymerization | 22/2078 | 114/18723 | 6.73e-03 | 4.77e-02 | 22 |
| GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CKAP5 | SNV | Missense_Mutation | c.3470N>G | p.Ser1157Cys | p.S1157C | Q14008 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
| CKAP5 | SNV | Missense_Mutation | novel | c.4878G>C | p.Gln1626His | p.Q1626H | Q14008 | protein_coding | tolerated(0.07) | possibly_damaging(0.556) | TCGA-A2-A3XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | PR |
| CKAP5 | SNV | Missense_Mutation | c.5440G>A | p.Glu1814Lys | p.E1814K | Q14008 | protein_coding | tolerated(0.19) | probably_damaging(0.98) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| CKAP5 | SNV | Missense_Mutation | c.5491G>A | p.Asp1831Asn | p.D1831N | Q14008 | protein_coding | tolerated(0.06) | probably_damaging(0.989) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD | |
| CKAP5 | SNV | Missense_Mutation | novel | c.1116N>T | p.Glu372Asp | p.E372D | Q14008 | protein_coding | tolerated(0.05) | probably_damaging(0.971) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CKAP5 | SNV | Missense_Mutation | c.5737C>G | p.Pro1913Ala | p.P1913A | Q14008 | protein_coding | tolerated(0.64) | benign(0.015) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CKAP5 | SNV | Missense_Mutation | c.5000N>T | p.Ser1667Phe | p.S1667F | Q14008 | protein_coding | deleterious(0.04) | possibly_damaging(0.603) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD | |
| CKAP5 | SNV | Missense_Mutation | novel | c.2166N>A | p.Met722Ile | p.M722I | Q14008 | protein_coding | tolerated(0.17) | benign(0) | TCGA-AR-A2LR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| CKAP5 | SNV | Missense_Mutation | c.4459N>T | p.Asp1487Tyr | p.D1487Y | Q14008 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| CKAP5 | SNV | Missense_Mutation | c.42N>C | p.Gln14His | p.Q14H | Q14008 | protein_coding | deleterious(0.01) | probably_damaging(0.964) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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