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Gene: CIZ1 |
Gene summary for CIZ1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CIZ1 | Gene ID | 25792 |
| Gene name | CDKN1A interacting zinc finger protein 1 | |
| Gene Alias | LSFR1 | |
| Cytomap | 9q34.11 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BTG3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 25792 | CIZ1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.15e-05 | 2.04e-01 | 0.0155 |
| 25792 | CIZ1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.93e-02 | 2.17e-01 | -0.1808 |
| 25792 | CIZ1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.93e-03 | 2.46e-01 | -0.1088 |
| 25792 | CIZ1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.60e-11 | 3.43e-01 | -0.1954 |
| 25792 | CIZ1 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.99e-04 | 4.63e-01 | -0.2602 |
| 25792 | CIZ1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.19e-05 | 3.95e-01 | -0.1207 |
| 25792 | CIZ1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.74e-06 | 3.05e-01 | -0.1464 |
| 25792 | CIZ1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.92e-05 | 2.60e-01 | -0.1001 |
| 25792 | CIZ1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.10e-17 | 5.32e-01 | -0.059 |
| 25792 | CIZ1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.16e-02 | 2.95e-01 | -0.0842 |
| 25792 | CIZ1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.81e-05 | 4.31e-01 | -0.00410000000000005 |
| 25792 | CIZ1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.86e-15 | 4.17e-01 | 0.096 |
| 25792 | CIZ1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.75e-02 | 3.34e-01 | 0.0446 |
| 25792 | CIZ1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.66e-04 | 3.51e-01 | 0.0528 |
| 25792 | CIZ1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.87e-06 | 2.89e-01 | 0.0338 |
| 25792 | CIZ1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.56e-14 | 4.06e-01 | 0.0674 |
| 25792 | CIZ1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.26e-05 | 3.82e-01 | 0.0112 |
| 25792 | CIZ1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 8.53e-03 | 5.31e-01 | -0.0124 |
| 25792 | CIZ1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.63e-05 | 3.02e-01 | 0.0588 |
| 25792 | CIZ1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.00e-05 | 2.92e-01 | 0.294 |
| Page: 1 2 3 4 5 6 7 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
| GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
| GO:0032507 | Colorectum | AD | maintenance of protein location in cell | 25/3918 | 65/18723 | 9.12e-04 | 8.71e-03 | 25 |
| GO:0051651 | Colorectum | AD | maintenance of location in cell | 61/3918 | 214/18723 | 5.02e-03 | 3.37e-02 | 61 |
| GO:0045185 | Colorectum | AD | maintenance of protein location | 30/3918 | 94/18723 | 8.26e-03 | 4.85e-02 | 30 |
| GO:00345041 | Colorectum | SER | protein localization to nucleus | 74/2897 | 290/18723 | 5.74e-06 | 2.05e-04 | 74 |
| GO:00510541 | Colorectum | SER | positive regulation of DNA metabolic process | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
| GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
| GO:00325071 | Colorectum | SER | maintenance of protein location in cell | 21/2897 | 65/18723 | 5.39e-04 | 7.57e-03 | 21 |
| GO:00451851 | Colorectum | SER | maintenance of protein location | 26/2897 | 94/18723 | 1.76e-03 | 1.81e-02 | 26 |
| GO:00516511 | Colorectum | SER | maintenance of location in cell | 47/2897 | 214/18723 | 7.20e-03 | 4.99e-02 | 47 |
| GO:00345042 | Colorectum | MSS | protein localization to nucleus | 92/3467 | 290/18723 | 3.66e-08 | 1.98e-06 | 92 |
| GO:00510522 | Colorectum | MSS | regulation of DNA metabolic process | 108/3467 | 359/18723 | 5.86e-08 | 3.10e-06 | 108 |
| GO:00510542 | Colorectum | MSS | positive regulation of DNA metabolic process | 69/3467 | 201/18723 | 6.33e-08 | 3.26e-06 | 69 |
| GO:00516512 | Colorectum | MSS | maintenance of location in cell | 57/3467 | 214/18723 | 2.07e-03 | 1.76e-02 | 57 |
| GO:00325072 | Colorectum | MSS | maintenance of protein location in cell | 22/3467 | 65/18723 | 2.33e-03 | 1.90e-02 | 22 |
| GO:00510543 | Colorectum | MSI-H | positive regulation of DNA metabolic process | 34/1319 | 201/18723 | 1.60e-06 | 1.03e-04 | 34 |
| GO:00345043 | Colorectum | MSI-H | protein localization to nucleus | 40/1319 | 290/18723 | 3.43e-05 | 1.33e-03 | 40 |
| GO:00510523 | Colorectum | MSI-H | regulation of DNA metabolic process | 45/1319 | 359/18723 | 1.20e-04 | 3.56e-03 | 45 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CIZ1 | SNV | Missense_Mutation | novel | c.2398N>A | p.Glu800Lys | p.E800K | protein_coding | tolerated(0.05) | possibly_damaging(0.702) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
| CIZ1 | SNV | Missense_Mutation | rs770956884 | c.458N>A | p.Arg153Gln | p.R153Q | protein_coding | deleterious(0) | benign(0.343) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
| CIZ1 | SNV | Missense_Mutation | novel | c.1262N>A | p.Val421Glu | p.V421E | protein_coding | tolerated_low_confidence(0.31) | probably_damaging(0.997) | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| CIZ1 | SNV | Missense_Mutation | c.2668N>T | p.Ala890Ser | p.A890S | protein_coding | tolerated(0.06) | benign(0.335) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| CIZ1 | SNV | Missense_Mutation | c.1033N>T | p.Val345Phe | p.V345F | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.983) | TCGA-D8-A27I-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adrimycin+cyclophosphamide | SD | ||
| CIZ1 | insertion | Nonsense_Mutation | novel | c.2077_2078insTAGTGTGTTCCAGGTGTGTGTACCAAGCACTATCCTG | p.Tyr693LeufsTer13 | p.Y693Lfs*13 | protein_coding | TCGA-B6-A0I9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |||
| CIZ1 | deletion | Frame_Shift_Del | novel | c.816delA | p.Lys272AsnfsTer21 | p.K272Nfs*21 | protein_coding | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
| CIZ1 | SNV | Missense_Mutation | c.620C>T | p.Ser207Leu | p.S207L | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | ||
| CIZ1 | SNV | Missense_Mutation | c.2035G>A | p.Glu679Lys | p.E679K | protein_coding | tolerated(0.06) | possibly_damaging(0.457) | TCGA-Q1-A73P-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
| CIZ1 | SNV | Missense_Mutation | rs751261139 | c.1723G>A | p.Gly575Arg | p.G575R | protein_coding | deleterious(0) | benign(0.401) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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