Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CIAO2B

Gene summary for CIAO2B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CIAO2B

Gene ID

51647

Gene namecytosolic iron-sulfur assembly component 2B
Gene AliasCGI-128
Cytomap16q22.1
Gene Typeprotein-coding
GO ID

GO:0006790

UniProtAcc

Q9Y3D0


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51647CIAO2BCA_HPV_1HumanCervixCC4.30e-09-1.71e-010.0264
51647CIAO2BCA_HPV_3HumanCervixCC7.99e-054.47e-020.0414
51647CIAO2BN_HPV_2HumanCervixN_HPV1.90e-026.64e-02-0.0131
51647CIAO2BCCI_1HumanCervixCC1.38e-07-6.49e-010.528
51647CIAO2BCCI_3HumanCervixCC4.75e-10-6.43e-010.516
51647CIAO2BCCII_1HumanCervixCC7.79e-21-6.90e-010.3249
51647CIAO2BTumorHumanCervixCC3.88e-43-6.90e-010.1241
51647CIAO2Bsample3HumanCervixCC2.81e-02-1.67e-010.1387
51647CIAO2BH2HumanCervixHSIL_HPV6.68e-06-3.98e-010.0632
51647CIAO2BL1HumanCervixCC9.19e-04-2.23e-010.0802
51647CIAO2BHTA11_3410_2000001011HumanColorectumAD6.00e-081.74e-010.0155
51647CIAO2BHTA11_2487_2000001011HumanColorectumSER3.26e-236.41e-01-0.1808
51647CIAO2BHTA11_2951_2000001011HumanColorectumAD3.40e-022.22e-010.0216
51647CIAO2BHTA11_1938_2000001011HumanColorectumAD8.58e-133.82e-01-0.0811
51647CIAO2BHTA11_78_2000001011HumanColorectumAD2.20e-051.60e-01-0.1088
51647CIAO2BHTA11_347_2000001011HumanColorectumAD2.45e-204.03e-01-0.1954
51647CIAO2BHTA11_411_2000001011HumanColorectumSER6.89e-149.28e-01-0.2602
51647CIAO2BHTA11_2112_2000001011HumanColorectumSER8.76e-085.59e-01-0.2196
51647CIAO2BHTA11_3361_2000001011HumanColorectumAD3.86e-113.70e-01-0.1207
51647CIAO2BHTA11_83_2000001011HumanColorectumSER1.46e-113.95e-01-0.1526
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00516048CervixCCprotein maturation56/2311294/187235.90e-045.59e-0356
GO:005160414CervixN_HPVprotein maturation20/534294/187233.17e-044.75e-0320
GO:0006790ColorectumADsulfur compound metabolic process101/3918339/187236.46e-051.07e-03101
GO:0051604ColorectumADprotein maturation85/3918294/187236.73e-046.91e-0385
GO:00516041ColorectumSERprotein maturation73/2897294/187231.82e-055.38e-0473
GO:00067901ColorectumSERsulfur compound metabolic process73/2897339/187231.75e-031.81e-0273
GO:005160417EsophagusHGINprotein maturation68/2587294/187239.77e-062.86e-0468
GO:00070593EsophagusHGINchromosome segregation71/2587346/187233.47e-045.62e-0371
GO:00974282EsophagusHGINprotein maturation by iron-sulfur cluster transfer8/258716/187236.00e-048.41e-038
GO:00162263EsophagusHGINiron-sulfur cluster assembly10/258726/187231.60e-031.79e-0210
GO:00311633EsophagusHGINmetallo-sulfur cluster assembly10/258726/187231.60e-031.79e-0210
GO:000705911EsophagusESCCchromosome segregation238/8552346/187231.72e-181.82e-16238
GO:005160418EsophagusESCCprotein maturation189/8552294/187237.64e-112.39e-09189
GO:00067906EsophagusESCCsulfur compound metabolic process201/8552339/187232.64e-073.94e-06201
GO:001622611EsophagusESCCiron-sulfur cluster assembly21/855226/187232.69e-041.63e-0321
GO:003116311EsophagusESCCmetallo-sulfur cluster assembly21/855226/187232.69e-041.63e-0321
GO:009742811EsophagusESCCprotein maturation by iron-sulfur cluster transfer14/855216/187236.78e-043.56e-0314
GO:00516049ProstateBPHprotein maturation80/3107294/187232.64e-064.23e-0580
GO:005160415ProstateTumorprotein maturation81/3246294/187237.58e-061.13e-0481
GO:00070594SkinAKchromosome segregation60/1910346/187232.88e-054.98e-0460
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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