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Gene: CHSY3 |
Gene summary for CHSY3 |
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Gene information | Species | Human | Gene symbol | CHSY3 | Gene ID | 337876 |
Gene name | chondroitin sulfate synthase 3 | |
Gene Alias | CHSY2 | |
Cytomap | 5q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006022 | UniProtAcc | Q70JA7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
337876 | CHSY3 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 3.17e-04 | 6.23e-01 | -0.1271 |
337876 | CHSY3 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.30e-05 | 7.84e-01 | -0.1406 |
337876 | CHSY3 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.24e-04 | 6.91e-01 | -0.138 |
337876 | CHSY3 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.70e-10 | 5.90e-01 | -0.2116 |
337876 | CHSY3 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 7.22e-04 | 5.09e-01 | -0.2107 |
337876 | CHSY3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 2.01e-09 | 6.56e-01 | -0.2119 |
337876 | CHSY3 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.39e-11 | 4.49e-01 | -0.0166 |
337876 | CHSY3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.46e-17 | 5.24e-01 | -0.0132 |
337876 | CHSY3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.84e-18 | 5.27e-01 | -0.013 |
337876 | CHSY3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 9.40e-17 | 5.64e-01 | -0.0121 |
337876 | CHSY3 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.37e-02 | 3.76e-01 | -0.0961 |
337876 | CHSY3 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 8.94e-07 | 5.10e-01 | -0.0876 |
337876 | CHSY3 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 2.91e-02 | 3.96e-01 | -0.0822 |
337876 | CHSY3 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.35e-06 | 6.03e-01 | -0.0809 |
337876 | CHSY3 | RNA-P8T2-P8T2-1 | Human | Lung | AIS | 2.03e-09 | 1.50e+00 | -0.1263 |
337876 | CHSY3 | RNA-P8T2-P8T2-3 | Human | Lung | AIS | 1.04e-04 | 8.92e-01 | -0.1284 |
337876 | CHSY3 | RNA-P8T2-P8T2-4 | Human | Lung | AIS | 3.02e-07 | 1.16e+00 | -0.1197 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHSY3 | SNV | Missense_Mutation | c.1013N>A | p.Thr338Lys | p.T338K | Q70JA7 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-A2-A0EU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHSY3 | SNV | Missense_Mutation | c.937N>G | p.Pro313Ala | p.P313A | Q70JA7 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
CHSY3 | SNV | Missense_Mutation | novel | c.2422N>T | p.Val808Leu | p.V808L | Q70JA7 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
CHSY3 | SNV | Missense_Mutation | c.1192N>T | p.Arg398Trp | p.R398W | Q70JA7 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-BH-A0BG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHSY3 | SNV | Missense_Mutation | rs772498988 | c.1894G>A | p.Asp632Asn | p.D632N | Q70JA7 | protein_coding | tolerated(0.08) | benign(0.139) | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
CHSY3 | SNV | Missense_Mutation | rs866412530 | c.1718N>A | p.Arg573Lys | p.R573K | Q70JA7 | protein_coding | tolerated(0.47) | benign(0.01) | TCGA-EW-A1IX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | femara | SD |
CHSY3 | insertion | In_Frame_Ins | novel | c.1918_1919insGACGGCTCATTGACTTCAAGGAAATTCAGTATGGCT | p.Asn640delinsArgArgLeuIleAspPheLysGluIleGlnTyrGlyTyr | p.N640delinsRRLIDFKEIQYGY | Q70JA7 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
CHSY3 | insertion | In_Frame_Ins | novel | c.1923_1924insCACTTCATCCCAACAAAA | p.Phe641_Glu642insHisPheIleProThrLys | p.F641_E642insHFIPTK | Q70JA7 | protein_coding | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
CHSY3 | insertion | Frame_Shift_Ins | novel | c.1924_1925insGCCTGCATACC | p.Glu642GlyfsTer15 | p.E642Gfs*15 | Q70JA7 | protein_coding | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
CHSY3 | insertion | Nonsense_Mutation | novel | c.2345_2346insAAGACCTTCACAATAGCAAAATCCATGCAGC | p.Thr783ArgfsTer5 | p.T783Rfs*5 | Q70JA7 | protein_coding | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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