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Gene: CHN2 |
Gene summary for CHN2 |
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Gene information | Species | Human | Gene symbol | CHN2 | Gene ID | 1124 |
Gene name | chimerin 2 | |
Gene Alias | ARHGAP3 | |
Cytomap | 7p14.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | P52757 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1124 | CHN2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.41e-17 | 3.85e-01 | 0.0155 |
1124 | CHN2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.80e-32 | 8.85e-01 | -0.1808 |
1124 | CHN2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.20e-14 | 7.78e-01 | 0.0216 |
1124 | CHN2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.45e-32 | 7.71e-01 | -0.0811 |
1124 | CHN2 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.01e-50 | 1.15e+00 | -0.1088 |
1124 | CHN2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-53 | 1.01e+00 | -0.1954 |
1124 | CHN2 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.29e-21 | 1.44e+00 | -0.2602 |
1124 | CHN2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.88e-11 | 7.52e-01 | -0.2196 |
1124 | CHN2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.42e-20 | 6.72e-01 | -0.1207 |
1124 | CHN2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.91e-27 | 1.04e+00 | -0.1526 |
1124 | CHN2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.94e-62 | 1.16e+00 | -0.1464 |
1124 | CHN2 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.14e-46 | 8.78e-01 | -0.1001 |
1124 | CHN2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.33e-38 | 1.10e+00 | -0.059 |
1124 | CHN2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.50e-12 | 7.14e-01 | -0.1706 |
1124 | CHN2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.32e-13 | 5.85e-01 | -0.2061 |
1124 | CHN2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.20e-12 | 5.38e-01 | -0.1462 |
1124 | CHN2 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.21e-19 | 8.30e-01 | -0.0842 |
1124 | CHN2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.27e-11 | 3.72e-01 | -0.0179 |
1124 | CHN2 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.51e-34 | 6.81e-01 | 0.096 |
1124 | CHN2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.20e-12 | 7.37e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0043547 | Colorectum | AD | positive regulation of GTPase activity | 75/3918 | 255/18723 | 7.95e-04 | 7.91e-03 | 75 |
GO:00430871 | Colorectum | SER | regulation of GTPase activity | 77/2897 | 348/18723 | 5.90e-04 | 8.07e-03 | 77 |
GO:00430872 | Colorectum | MSS | regulation of GTPase activity | 101/3467 | 348/18723 | 1.00e-06 | 3.46e-05 | 101 |
GO:00510561 | Colorectum | MSS | regulation of small GTPase mediated signal transduction | 82/3467 | 302/18723 | 1.31e-04 | 1.99e-03 | 82 |
GO:00435471 | Colorectum | MSS | positive regulation of GTPase activity | 68/3467 | 255/18723 | 7.97e-04 | 8.38e-03 | 68 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHN2 | SNV | Missense_Mutation | c.678N>A | p.His226Gln | p.H226Q | P52757 | protein_coding | tolerated(0.11) | probably_damaging(0.985) | TCGA-A2-A04N-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | |
CHN2 | SNV | Missense_Mutation | c.153N>G | p.Asn51Lys | p.N51K | P52757 | protein_coding | tolerated(0.09) | benign(0.054) | TCGA-AR-A24H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
CHN2 | SNV | Missense_Mutation | novel | c.538N>T | p.Thr180Ser | p.T180S | P52757 | protein_coding | tolerated(0.76) | benign(0.001) | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD |
CHN2 | SNV | Missense_Mutation | c.562N>G | p.Thr188Ala | p.T188A | P52757 | protein_coding | tolerated(0.75) | benign(0) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
CHN2 | insertion | Frame_Shift_Ins | novel | c.536_537insCAGTATATCAGAGTTTGTTTACATTTCCTCAGCCGCAGATGCT | p.Lys179AsnfsTer21 | p.K179Nfs*21 | P52757 | protein_coding | TCGA-BH-A0HX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adrimycin | SD | ||
CHN2 | SNV | Missense_Mutation | c.1238T>G | p.Val413Gly | p.V413G | P52757 | protein_coding | deleterious(0) | benign(0.213) | TCGA-JX-A3PZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
CHN2 | SNV | Missense_Mutation | c.248G>C | p.Arg83Thr | p.R83T | P52757 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CHN2 | SNV | Missense_Mutation | novel | c.1070G>C | p.Arg357Thr | p.R357T | P52757 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CHN2 | deletion | Frame_Shift_Del | novel | c.510_520delGAGCAGGTCTA | p.Ser171LysfsTer2 | p.S171Kfs*2 | P52757 | protein_coding | TCGA-VS-A9V2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
CHN2 | SNV | Missense_Mutation | c.718N>A | p.Ala240Thr | p.A240T | P52757 | protein_coding | tolerated(0.07) | probably_damaging(0.995) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1124 | CHN2 | NA | fluorouracil | FLUOROURACIL | 24444404 |
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