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Gene: CHMP7 |
Gene summary for CHMP7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CHMP7 | Gene ID | 91782 |
| Gene name | charged multivesicular body protein 7 | |
| Gene Alias | CHMP7 | |
| Cytomap | 8p21.3 | |
| Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | B3KMN6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 91782 | CHMP7 | LZE4T | Human | Esophagus | ESCC | 5.67e-13 | 2.49e-01 | 0.0811 |
| 91782 | CHMP7 | LZE7T | Human | Esophagus | ESCC | 2.57e-04 | 2.07e-01 | 0.0667 |
| 91782 | CHMP7 | LZE22T | Human | Esophagus | ESCC | 8.33e-04 | 1.63e-01 | 0.068 |
| 91782 | CHMP7 | LZE24T | Human | Esophagus | ESCC | 3.03e-15 | 3.20e-01 | 0.0596 |
| 91782 | CHMP7 | LZE6T | Human | Esophagus | ESCC | 3.97e-03 | 7.97e-02 | 0.0845 |
| 91782 | CHMP7 | P1T-E | Human | Esophagus | ESCC | 1.17e-02 | 2.88e-01 | 0.0875 |
| 91782 | CHMP7 | P2T-E | Human | Esophagus | ESCC | 2.44e-22 | 3.40e-01 | 0.1177 |
| 91782 | CHMP7 | P4T-E | Human | Esophagus | ESCC | 3.61e-15 | 2.38e-01 | 0.1323 |
| 91782 | CHMP7 | P5T-E | Human | Esophagus | ESCC | 4.68e-04 | 2.06e-02 | 0.1327 |
| 91782 | CHMP7 | P8T-E | Human | Esophagus | ESCC | 1.02e-09 | 1.37e-01 | 0.0889 |
| 91782 | CHMP7 | P9T-E | Human | Esophagus | ESCC | 4.85e-09 | 1.03e-01 | 0.1131 |
| 91782 | CHMP7 | P10T-E | Human | Esophagus | ESCC | 2.08e-12 | 2.00e-01 | 0.116 |
| 91782 | CHMP7 | P11T-E | Human | Esophagus | ESCC | 2.80e-08 | 2.35e-01 | 0.1426 |
| 91782 | CHMP7 | P12T-E | Human | Esophagus | ESCC | 5.38e-15 | 2.14e-01 | 0.1122 |
| 91782 | CHMP7 | P15T-E | Human | Esophagus | ESCC | 1.22e-05 | 1.27e-01 | 0.1149 |
| 91782 | CHMP7 | P16T-E | Human | Esophagus | ESCC | 8.60e-18 | 2.91e-01 | 0.1153 |
| 91782 | CHMP7 | P17T-E | Human | Esophagus | ESCC | 4.63e-11 | 1.94e-01 | 0.1278 |
| 91782 | CHMP7 | P19T-E | Human | Esophagus | ESCC | 4.96e-04 | 2.86e-01 | 0.1662 |
| 91782 | CHMP7 | P20T-E | Human | Esophagus | ESCC | 5.97e-18 | 3.83e-01 | 0.1124 |
| 91782 | CHMP7 | P21T-E | Human | Esophagus | ESCC | 1.59e-08 | 1.99e-01 | 0.1617 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
| GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
| GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
| GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
| GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
| GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
| GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
| GO:004477216 | Esophagus | ESCC | mitotic cell cycle phase transition | 281/8552 | 424/18723 | 4.63e-18 | 4.45e-16 | 281 |
| GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
| GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
| GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
| GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
| GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
| GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
| GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
| GO:0006900111 | Esophagus | ESCC | vesicle budding from membrane | 54/8552 | 61/18723 | 2.66e-12 | 1.07e-10 | 54 |
| GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
| GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
| Page: 1 2 3 4 5 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
| hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
| hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
| hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CHMP7 | SNV | Missense_Mutation | c.1048C>G | p.Gln350Glu | p.Q350E | Q8WUX9 | protein_coding | tolerated(0.14) | benign(0.076) | TCGA-A8-A09G-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
| CHMP7 | SNV | Missense_Mutation | rs776751717 | c.757N>T | p.Arg253Cys | p.R253C | Q8WUX9 | protein_coding | deleterious(0.02) | possibly_damaging(0.744) | TCGA-E9-A1RH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD |
| CHMP7 | SNV | Missense_Mutation | rs760597457 | c.1208N>A | p.Arg403His | p.R403H | Q8WUX9 | protein_coding | tolerated(0.28) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| CHMP7 | SNV | Missense_Mutation | c.580G>A | p.Glu194Lys | p.E194K | Q8WUX9 | protein_coding | deleterious(0.03) | possibly_damaging(0.468) | TCGA-DS-A7WF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
| CHMP7 | SNV | Missense_Mutation | rs149875498 | c.881N>A | p.Arg294His | p.R294H | Q8WUX9 | protein_coding | tolerated(0.05) | benign(0.051) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| CHMP7 | SNV | Missense_Mutation | c.1256C>T | p.Ala419Val | p.A419V | Q8WUX9 | protein_coding | tolerated(0.21) | probably_damaging(0.935) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
| CHMP7 | SNV | Missense_Mutation | novel | c.886N>A | p.Glu296Lys | p.E296K | Q8WUX9 | protein_coding | tolerated(0.27) | benign(0.013) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| CHMP7 | deletion | Frame_Shift_Del | c.367delG | p.Val123LeufsTer6 | p.V123Lfs*6 | Q8WUX9 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |||
| CHMP7 | SNV | Missense_Mutation | rs139229850 | c.302N>T | p.Arg101Leu | p.R101L | Q8WUX9 | protein_coding | tolerated(0.4) | benign(0.087) | TCGA-AJ-A3QS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
| CHMP7 | SNV | Missense_Mutation | rs748059267 | c.758N>A | p.Arg253His | p.R253H | Q8WUX9 | protein_coding | tolerated(0.07) | possibly_damaging(0.493) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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