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Gene: CHD1L |
Gene summary for CHD1L |
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Gene information | Species | Human | Gene symbol | CHD1L | Gene ID | 9557 |
Gene name | chromodomain helicase DNA binding protein 1 like | |
Gene Alias | ALC1 | |
Cytomap | 1q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A0A0MSH9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9557 | CHD1L | LZE4T | Human | Esophagus | ESCC | 2.61e-10 | 2.48e-01 | 0.0811 |
9557 | CHD1L | LZE7T | Human | Esophagus | ESCC | 8.34e-06 | 2.67e-01 | 0.0667 |
9557 | CHD1L | LZE24T | Human | Esophagus | ESCC | 4.70e-05 | 9.84e-02 | 0.0596 |
9557 | CHD1L | LZE21T | Human | Esophagus | ESCC | 2.87e-03 | 2.03e-01 | 0.0655 |
9557 | CHD1L | P2T-E | Human | Esophagus | ESCC | 1.73e-30 | 6.42e-01 | 0.1177 |
9557 | CHD1L | P4T-E | Human | Esophagus | ESCC | 9.76e-15 | 3.35e-01 | 0.1323 |
9557 | CHD1L | P5T-E | Human | Esophagus | ESCC | 1.79e-19 | 3.44e-01 | 0.1327 |
9557 | CHD1L | P8T-E | Human | Esophagus | ESCC | 5.47e-12 | 1.30e-01 | 0.0889 |
9557 | CHD1L | P9T-E | Human | Esophagus | ESCC | 1.48e-09 | 1.57e-01 | 0.1131 |
9557 | CHD1L | P10T-E | Human | Esophagus | ESCC | 3.05e-20 | 2.76e-01 | 0.116 |
9557 | CHD1L | P11T-E | Human | Esophagus | ESCC | 4.04e-07 | 4.27e-01 | 0.1426 |
9557 | CHD1L | P12T-E | Human | Esophagus | ESCC | 2.93e-13 | 2.92e-01 | 0.1122 |
9557 | CHD1L | P15T-E | Human | Esophagus | ESCC | 8.35e-11 | 3.40e-01 | 0.1149 |
9557 | CHD1L | P16T-E | Human | Esophagus | ESCC | 1.54e-16 | 3.45e-01 | 0.1153 |
9557 | CHD1L | P17T-E | Human | Esophagus | ESCC | 4.49e-04 | 1.87e-01 | 0.1278 |
9557 | CHD1L | P20T-E | Human | Esophagus | ESCC | 5.80e-04 | 1.39e-01 | 0.1124 |
9557 | CHD1L | P21T-E | Human | Esophagus | ESCC | 1.33e-19 | 3.30e-01 | 0.1617 |
9557 | CHD1L | P22T-E | Human | Esophagus | ESCC | 6.13e-30 | 5.75e-01 | 0.1236 |
9557 | CHD1L | P23T-E | Human | Esophagus | ESCC | 1.96e-15 | 4.04e-01 | 0.108 |
9557 | CHD1L | P24T-E | Human | Esophagus | ESCC | 2.11e-26 | 4.97e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:003239214 | Esophagus | ESCC | DNA geometric change | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:003250813 | Esophagus | ESCC | DNA duplex unwinding | 58/8552 | 84/18723 | 1.23e-05 | 1.14e-04 | 58 |
GO:00063255 | Liver | NAFLD | chromatin organization | 64/1882 | 409/18723 | 2.31e-04 | 3.89e-03 | 64 |
GO:00323922 | Liver | NAFLD | DNA geometric change | 18/1882 | 90/18723 | 3.34e-03 | 2.93e-02 | 18 |
GO:003239211 | Liver | HCC | DNA geometric change | 54/7958 | 90/18723 | 6.04e-04 | 3.79e-03 | 54 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:00325081 | Liver | HCC | DNA duplex unwinding | 49/7958 | 84/18723 | 2.46e-03 | 1.19e-02 | 49 |
GO:00323925 | Oral cavity | OSCC | DNA geometric change | 59/7305 | 90/18723 | 3.03e-07 | 4.63e-06 | 59 |
GO:00325083 | Oral cavity | OSCC | DNA duplex unwinding | 55/7305 | 84/18723 | 8.05e-07 | 1.12e-05 | 55 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:003239215 | Skin | cSCC | DNA geometric change | 44/4864 | 90/18723 | 2.53e-06 | 4.06e-05 | 44 |
GO:000632519 | Skin | cSCC | chromatin organization | 147/4864 | 409/18723 | 4.41e-06 | 6.52e-05 | 147 |
GO:003250814 | Skin | cSCC | DNA duplex unwinding | 40/4864 | 84/18723 | 1.58e-05 | 1.94e-04 | 40 |
GO:000633812 | Skin | cSCC | chromatin remodeling | 94/4864 | 255/18723 | 7.58e-05 | 7.26e-04 | 94 |
GO:00711031 | Skin | cSCC | DNA conformation change | 96/4864 | 290/18723 | 3.87e-03 | 2.07e-02 | 96 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHD1L | SNV | Missense_Mutation | novel | c.2556N>C | p.Trp852Cys | p.W852C | Q86WJ1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHD1L | SNV | Missense_Mutation | rs200997862 | c.1897C>T | p.Arg633Trp | p.R633W | Q86WJ1 | protein_coding | deleterious(0.02) | benign(0.02) | TCGA-A8-A08L-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHD1L | SNV | Missense_Mutation | c.2092G>C | p.Glu698Gln | p.E698Q | Q86WJ1 | protein_coding | tolerated(0.1) | possibly_damaging(0.543) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CHD1L | SNV | Missense_Mutation | rs782045573 | c.178N>T | p.Arg60Cys | p.R60C | Q86WJ1 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AN-A0XP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHD1L | SNV | Missense_Mutation | c.1981A>G | p.Lys661Glu | p.K661E | Q86WJ1 | protein_coding | tolerated(0.26) | benign(0.003) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHD1L | SNV | Missense_Mutation | c.2273G>C | p.Arg758Pro | p.R758P | Q86WJ1 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-E2-A158-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | arimidex | SD | |
CHD1L | SNV | Missense_Mutation | rs142193146 | c.2218G>C | p.Val740Leu | p.V740L | Q86WJ1 | protein_coding | tolerated(0.08) | benign(0.021) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
CHD1L | SNV | Missense_Mutation | c.694N>C | p.Asp232His | p.D232H | Q86WJ1 | protein_coding | tolerated(0.06) | benign(0.059) | TCGA-E9-A3QA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHD1L | insertion | Frame_Shift_Ins | novel | c.1395dupA | p.Val466SerfsTer16 | p.V466Sfs*16 | Q86WJ1 | protein_coding | TCGA-B6-A0WY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
CHD1L | SNV | Missense_Mutation | novel | c.1090C>T | p.His364Tyr | p.H364Y | Q86WJ1 | protein_coding | deleterious(0.05) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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