![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CHCHD7 |
Gene summary for CHCHD7 |
![]() |
Gene information | Species | Human | Gene symbol | CHCHD7 | Gene ID | 79145 |
Gene name | coiled-coil-helix-coiled-coil-helix domain containing 7 | |
Gene Alias | COX23 | |
Cytomap | 8q12.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9BUK0 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79145 | CHCHD7 | LZE2T | Human | Esophagus | ESCC | 1.12e-07 | 1.57e+00 | 0.082 |
79145 | CHCHD7 | LZE4T | Human | Esophagus | ESCC | 2.26e-08 | 4.20e-01 | 0.0811 |
79145 | CHCHD7 | LZE7T | Human | Esophagus | ESCC | 4.09e-06 | 3.12e-01 | 0.0667 |
79145 | CHCHD7 | LZE8T | Human | Esophagus | ESCC | 7.40e-13 | 2.37e-01 | 0.067 |
79145 | CHCHD7 | LZE20T | Human | Esophagus | ESCC | 6.85e-24 | 9.81e-01 | 0.0662 |
79145 | CHCHD7 | LZE22T | Human | Esophagus | ESCC | 2.10e-06 | 4.13e-01 | 0.068 |
79145 | CHCHD7 | LZE24T | Human | Esophagus | ESCC | 5.25e-35 | 1.20e+00 | 0.0596 |
79145 | CHCHD7 | LZE21T | Human | Esophagus | ESCC | 5.50e-06 | 5.08e-01 | 0.0655 |
79145 | CHCHD7 | P1T-E | Human | Esophagus | ESCC | 3.32e-11 | 7.37e-01 | 0.0875 |
79145 | CHCHD7 | P2T-E | Human | Esophagus | ESCC | 1.59e-35 | 7.19e-01 | 0.1177 |
79145 | CHCHD7 | P4T-E | Human | Esophagus | ESCC | 1.94e-45 | 1.31e+00 | 0.1323 |
79145 | CHCHD7 | P5T-E | Human | Esophagus | ESCC | 8.24e-30 | 5.80e-01 | 0.1327 |
79145 | CHCHD7 | P8T-E | Human | Esophagus | ESCC | 1.87e-29 | 5.27e-01 | 0.0889 |
79145 | CHCHD7 | P9T-E | Human | Esophagus | ESCC | 8.90e-34 | 8.62e-01 | 0.1131 |
79145 | CHCHD7 | P10T-E | Human | Esophagus | ESCC | 3.62e-47 | 1.09e+00 | 0.116 |
79145 | CHCHD7 | P11T-E | Human | Esophagus | ESCC | 7.11e-14 | 4.01e-01 | 0.1426 |
79145 | CHCHD7 | P12T-E | Human | Esophagus | ESCC | 3.87e-42 | 7.10e-01 | 0.1122 |
79145 | CHCHD7 | P15T-E | Human | Esophagus | ESCC | 1.71e-21 | 5.37e-01 | 0.1149 |
79145 | CHCHD7 | P16T-E | Human | Esophagus | ESCC | 1.22e-38 | 8.20e-01 | 0.1153 |
79145 | CHCHD7 | P17T-E | Human | Esophagus | ESCC | 1.54e-20 | 1.22e+00 | 0.1278 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHCHD7 | SNV | Missense_Mutation | novel | c.76N>C | p.Met26Leu | p.M26L | Q9BUK0 | protein_coding | tolerated(0.06) | benign(0.198) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CHCHD7 | SNV | Missense_Mutation | novel | c.190N>G | p.Thr64Ala | p.T64A | Q9BUK0 | protein_coding | tolerated(1) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHCHD7 | SNV | Missense_Mutation | rs370320000 | c.238G>A | p.Val80Met | p.V80M | Q9BUK0 | protein_coding | tolerated(1) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHCHD7 | SNV | Missense_Mutation | novel | c.277C>T | p.Pro93Ser | p.P93S | Q9BUK0 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHCHD7 | SNV | Missense_Mutation | novel | c.311N>T | p.Ala104Val | p.A104V | Q9BUK0 | protein_coding | deleterious(0.01) | benign(0.062) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
CHCHD7 | SNV | Missense_Mutation | c.233N>A | p.Ser78Tyr | p.S78Y | Q9BUK0 | protein_coding | tolerated(0.06) | benign(0.406) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHCHD7 | SNV | Missense_Mutation | c.168C>A | p.Asn56Lys | p.N56K | Q9BUK0 | protein_coding | tolerated(0.1) | benign(0.346) | TCGA-EY-A2OP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHCHD7 | SNV | Missense_Mutation | c.88A>G | p.Thr30Ala | p.T30A | Q9BUK0 | protein_coding | tolerated(0.54) | benign(0.009) | TCGA-86-8075-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | etoposide | CR | |
CHCHD7 | insertion | In_Frame_Ins | novel | c.228_228+1insAATTCTATCGTGATGCAGAGAAGAAAGAACGGA | p.Asn77_Gly87dup | p.N77_G87dup | Q9BUK0 | protein_coding | TCGA-63-5128-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | ||
CHCHD7 | SNV | Missense_Mutation | c.142T>C | p.Ser48Pro | p.S48P | Q9BUK0 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |