![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CHCHD1 |
Gene summary for CHCHD1 |
![]() |
Gene information | Species | Human | Gene symbol | CHCHD1 | Gene ID | 118487 |
Gene name | coiled-coil-helix-coiled-coil-helix domain containing 1 | |
Gene Alias | C10orf34 | |
Cytomap | 10q22.2 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q96BP2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
118487 | CHCHD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 7.59e-08 | 2.59e-01 | -0.1808 |
118487 | CHCHD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.79e-06 | 3.17e-01 | -0.0811 |
118487 | CHCHD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.62e-12 | 2.20e-01 | -0.1954 |
118487 | CHCHD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.64e-03 | 1.90e-01 | -0.1207 |
118487 | CHCHD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.49e-04 | 1.70e-01 | -0.1464 |
118487 | CHCHD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.46e-02 | 1.45e-01 | -0.1001 |
118487 | CHCHD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.02e-09 | 3.86e-01 | -0.059 |
118487 | CHCHD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.50e-08 | 1.76e-01 | 0.096 |
118487 | CHCHD1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.48e-07 | 3.91e-01 | 0.0446 |
118487 | CHCHD1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.75e-04 | 2.83e-01 | 0.0528 |
118487 | CHCHD1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.62e-02 | 2.08e-01 | 0.0131 |
118487 | CHCHD1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.62e-07 | 5.49e-01 | 0.0171 |
118487 | CHCHD1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.16e-03 | 1.59e-01 | 0.0338 |
118487 | CHCHD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.96e-04 | 1.57e-01 | 0.0674 |
118487 | CHCHD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.18e-08 | 2.89e-01 | 0.294 |
118487 | CHCHD1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.56e-09 | 2.65e-01 | 0.281 |
118487 | CHCHD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.52e-07 | 2.66e-01 | 0.3859 |
118487 | CHCHD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.76e-06 | 1.86e-01 | 0.3005 |
118487 | CHCHD1 | LZE4T | Human | Esophagus | ESCC | 7.60e-10 | 1.85e-01 | 0.0811 |
118487 | CHCHD1 | LZE7T | Human | Esophagus | ESCC | 2.45e-04 | 4.47e-01 | 0.0667 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004603410 | Cervix | CC | ATP metabolic process | 90/2311 | 277/18723 | 7.90e-19 | 2.36e-15 | 90 |
GO:000611910 | Cervix | CC | oxidative phosphorylation | 55/2311 | 141/18723 | 7.12e-16 | 1.42e-12 | 55 |
GO:00090609 | Cervix | CC | aerobic respiration | 60/2311 | 189/18723 | 1.59e-12 | 6.36e-10 | 60 |
GO:00453339 | Cervix | CC | cellular respiration | 66/2311 | 230/18723 | 2.07e-11 | 5.39e-09 | 66 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:00060919 | Cervix | CC | generation of precursor metabolites and energy | 105/2311 | 490/18723 | 7.40e-09 | 6.61e-07 | 105 |
GO:00159809 | Cervix | CC | energy derivation by oxidation of organic compounds | 74/2311 | 318/18723 | 3.83e-08 | 2.53e-06 | 74 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:00345048 | Cervix | CC | protein localization to nucleus | 68/2311 | 290/18723 | 9.91e-08 | 5.25e-06 | 68 |
GO:00068399 | Cervix | CC | mitochondrial transport | 60/2311 | 254/18723 | 4.21e-07 | 1.67e-05 | 60 |
GO:00325077 | Cervix | CC | maintenance of protein location in cell | 21/2311 | 65/18723 | 2.03e-05 | 3.71e-04 | 21 |
GO:004518510 | Cervix | CC | maintenance of protein location | 26/2311 | 94/18723 | 4.85e-05 | 7.34e-04 | 26 |
GO:00108218 | Cervix | CC | regulation of mitochondrion organization | 34/2311 | 144/18723 | 1.27e-04 | 1.58e-03 | 34 |
GO:00070067 | Cervix | CC | mitochondrial membrane organization | 28/2311 | 116/18723 | 3.28e-04 | 3.47e-03 | 28 |
GO:00725955 | Cervix | CC | maintenance of protein localization in organelle | 14/2311 | 42/18723 | 3.32e-04 | 3.49e-03 | 14 |
GO:00086379 | Cervix | CC | apoptotic mitochondrial changes | 25/2311 | 107/18723 | 1.11e-03 | 9.14e-03 | 25 |
GO:00108224 | Cervix | CC | positive regulation of mitochondrion organization | 19/2311 | 74/18723 | 1.30e-03 | 1.03e-02 | 19 |
GO:00514571 | Cervix | CC | maintenance of protein location in nucleus | 8/2311 | 23/18723 | 4.70e-03 | 2.82e-02 | 8 |
GO:00070074 | Cervix | CC | inner mitochondrial membrane organization | 11/2311 | 38/18723 | 4.94e-03 | 2.95e-02 | 11 |
GO:00343316 | Cervix | CC | cell junction maintenance | 10/2311 | 35/18723 | 7.99e-03 | 4.18e-02 | 10 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHCHD1 | SNV | Missense_Mutation | c.100N>T | p.Gly34Trp | p.G34W | Q96BP2 | protein_coding | deleterious(0) | possibly_damaging(0.731) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
CHCHD1 | SNV | Missense_Mutation | c.44A>G | p.Asn15Ser | p.N15S | Q96BP2 | protein_coding | tolerated(0.14) | possibly_damaging(0.549) | TCGA-AA-3655-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CHCHD1 | SNV | Missense_Mutation | novel | c.308A>C | p.Lys103Thr | p.K103T | Q96BP2 | protein_coding | tolerated(0.1) | benign(0.015) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
CHCHD1 | SNV | Missense_Mutation | novel | c.347A>G | p.Tyr116Cys | p.Y116C | Q96BP2 | protein_coding | deleterious_low_confidence(0.01) | benign(0.219) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
CHCHD1 | SNV | Missense_Mutation | novel | c.285G>T | p.Glu95Asp | p.E95D | Q96BP2 | protein_coding | tolerated(0.2) | benign(0.026) | TCGA-DD-A4ND-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
CHCHD1 | SNV | Missense_Mutation | novel | c.312G>C | p.Leu104Phe | p.L104F | Q96BP2 | protein_coding | deleterious(0.03) | benign(0.034) | TCGA-T3-A92M-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
CHCHD1 | SNV | Missense_Mutation | novel | c.124N>A | p.Glu42Lys | p.E42K | Q96BP2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BJ-A45J-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |