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Gene: CFAP45 |
Gene summary for CFAP45 |
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Gene information | Species | Human | Gene symbol | CFAP45 | Gene ID | 25790 |
Gene name | cilia and flagella associated protein 45 | |
Gene Alias | CCDC19 | |
Cytomap | 1q23.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UL16 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25790 | CFAP45 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 1.43e-02 | 5.96e-01 | -0.0296 |
25790 | CFAP45 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 3.94e-03 | 5.15e-01 | -0.0263 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00328861 | Lung | MIAC | regulation of microtubule-based process | 23/967 | 240/18723 | 3.27e-03 | 4.31e-02 | 23 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP45 | SNV | Missense_Mutation | c.421G>A | p.Ala141Thr | p.A141T | Q9UL16 | protein_coding | deleterious(0.01) | benign(0.017) | TCGA-AR-A24P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP45 | SNV | Missense_Mutation | rs753777685 | c.1207C>T | p.Arg403Cys | p.R403C | Q9UL16 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-BH-A18L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CFAP45 | SNV | Missense_Mutation | c.332N>T | p.Arg111Leu | p.R111L | Q9UL16 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-D8-A1JI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
CFAP45 | SNV | Missense_Mutation | c.1216G>A | p.Glu406Lys | p.E406K | Q9UL16 | protein_coding | deleterious(0) | possibly_damaging(0.764) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
CFAP45 | insertion | In_Frame_Ins | novel | c.45_46insCCATCCAAGGATAATAGCATCAGAGTA | p.Ala15_Ser16insProSerLysAspAsnSerIleArgVal | p.A15_S16insPSKDNSIRV | Q9UL16 | protein_coding | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CFAP45 | deletion | Frame_Shift_Del | novel | c.304delC | p.Leu102Ter | p.L102* | Q9UL16 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
CFAP45 | SNV | Missense_Mutation | novel | c.1327C>T | p.Arg443Trp | p.R443W | Q9UL16 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CFAP45 | SNV | Missense_Mutation | novel | c.1131N>C | p.Glu377Asp | p.E377D | Q9UL16 | protein_coding | deleterious(0.03) | possibly_damaging(0.767) | TCGA-EA-A43B-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CFAP45 | SNV | Missense_Mutation | novel | c.1519N>A | p.Ala507Thr | p.A507T | Q9UL16 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
CFAP45 | SNV | Missense_Mutation | novel | c.568N>A | p.Glu190Lys | p.E190K | Q9UL16 | protein_coding | deleterious(0) | possibly_damaging(0.487) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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