![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CFAP221 |
Gene summary for CFAP221 |
![]() |
Gene information | Species | Human | Gene symbol | CFAP221 | Gene ID | 200373 |
Gene name | cilia and flagella associated protein 221 | |
Gene Alias | FAP221 | |
Cytomap | 2q14.2 | |
Gene Type | protein-coding | GO ID | GO:0003341 | UniProtAcc | Q4G0U5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
200373 | CFAP221 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 2.32e-02 | 8.56e-01 | -0.1271 |
200373 | CFAP221 | RNA-P10T2-P10T2-2 | Human | Lung | AAH | 1.56e-04 | 8.42e-01 | -0.1406 |
200373 | CFAP221 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 2.64e-02 | 7.39e-01 | -0.1408 |
200373 | CFAP221 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 1.41e-02 | 6.75e-01 | -0.138 |
200373 | CFAP221 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.53e-18 | 8.74e-01 | -0.2116 |
200373 | CFAP221 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.12e-05 | 7.65e-01 | -0.1941 |
200373 | CFAP221 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 2.52e-07 | 7.76e-01 | -0.2107 |
200373 | CFAP221 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.45e-10 | 7.57e-01 | -0.2119 |
200373 | CFAP221 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.19e-30 | 9.14e-01 | -0.0166 |
200373 | CFAP221 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 5.11e-38 | 1.02e+00 | -0.0132 |
200373 | CFAP221 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.66e-37 | 9.49e-01 | -0.013 |
200373 | CFAP221 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.74e-26 | 8.55e-01 | -0.0121 |
200373 | CFAP221 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 3.98e-12 | 9.68e-01 | -0.0961 |
200373 | CFAP221 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 7.88e-12 | 8.56e-01 | -0.0876 |
200373 | CFAP221 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 5.56e-09 | 8.56e-01 | -0.0822 |
200373 | CFAP221 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 3.11e-10 | 8.87e-01 | -0.0809 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0060271 | Lung | IAC | cilium assembly | 55/2061 | 337/18723 | 1.84e-03 | 1.88e-02 | 55 |
GO:0044782 | Lung | IAC | cilium organization | 58/2061 | 368/18723 | 3.15e-03 | 2.75e-02 | 58 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CFAP221 | SNV | Missense_Mutation | novel | c.1982N>G | p.Asn661Ser | p.N661S | Q4G0U5 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AC-A2BK-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
CFAP221 | SNV | Missense_Mutation | novel | c.1378G>T | p.Ala460Ser | p.A460S | Q4G0U5 | protein_coding | deleterious(0.02) | possibly_damaging(0.741) | TCGA-AC-A3TM-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
CFAP221 | SNV | Missense_Mutation | rs552536625 | c.1297N>T | p.Arg433Cys | p.R433C | Q4G0U5 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | rs556658192 | c.1574N>A | p.Arg525Gln | p.R525Q | Q4G0U5 | protein_coding | tolerated(0.42) | benign(0.005) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CFAP221 | SNV | Missense_Mutation | c.1933N>A | p.Ala645Thr | p.A645T | Q4G0U5 | protein_coding | tolerated(0.13) | benign(0.171) | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP221 | SNV | Missense_Mutation | rs750449699 | c.1951N>A | p.Asp651Asn | p.D651N | Q4G0U5 | protein_coding | tolerated(0.12) | benign(0.007) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
CFAP221 | SNV | Missense_Mutation | rs546995825 | c.1505C>T | p.Ser502Leu | p.S502L | Q4G0U5 | protein_coding | tolerated(0.09) | benign(0.034) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CFAP221 | SNV | Missense_Mutation | rs570868554 | c.2467N>C | p.Glu823Gln | p.E823Q | Q4G0U5 | protein_coding | tolerated(0.13) | benign(0.159) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
CFAP221 | SNV | Missense_Mutation | c.2494N>T | p.Ala832Ser | p.A832S | Q4G0U5 | protein_coding | tolerated(0.05) | benign(0.131) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CFAP221 | SNV | Missense_Mutation | rs377738201 | c.1960N>A | p.Pro654Thr | p.P654T | Q4G0U5 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-AA-3831-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |