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Gene: CEP78 |
Gene summary for CEP78 |
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Gene information | Species | Human | Gene symbol | CEP78 | Gene ID | 84131 |
Gene name | centrosomal protein 78 | |
Gene Alias | C9orf81 | |
Cytomap | 9q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q5JTW2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84131 | CEP78 | LZE4T | Human | Esophagus | ESCC | 2.34e-05 | 1.93e-01 | 0.0811 |
84131 | CEP78 | LZE7T | Human | Esophagus | ESCC | 5.19e-08 | 4.62e-01 | 0.0667 |
84131 | CEP78 | LZE24T | Human | Esophagus | ESCC | 6.34e-10 | 2.10e-01 | 0.0596 |
84131 | CEP78 | P2T-E | Human | Esophagus | ESCC | 2.95e-31 | 5.48e-01 | 0.1177 |
84131 | CEP78 | P4T-E | Human | Esophagus | ESCC | 2.82e-11 | 2.62e-01 | 0.1323 |
84131 | CEP78 | P5T-E | Human | Esophagus | ESCC | 1.31e-02 | 1.14e-01 | 0.1327 |
84131 | CEP78 | P8T-E | Human | Esophagus | ESCC | 1.76e-11 | 1.26e-01 | 0.0889 |
84131 | CEP78 | P9T-E | Human | Esophagus | ESCC | 5.99e-03 | 7.18e-02 | 0.1131 |
84131 | CEP78 | P10T-E | Human | Esophagus | ESCC | 7.83e-20 | 2.94e-01 | 0.116 |
84131 | CEP78 | P11T-E | Human | Esophagus | ESCC | 1.52e-02 | 2.37e-01 | 0.1426 |
84131 | CEP78 | P12T-E | Human | Esophagus | ESCC | 1.61e-11 | 2.73e-01 | 0.1122 |
84131 | CEP78 | P15T-E | Human | Esophagus | ESCC | 8.10e-14 | 2.86e-01 | 0.1149 |
84131 | CEP78 | P16T-E | Human | Esophagus | ESCC | 2.03e-10 | 2.34e-01 | 0.1153 |
84131 | CEP78 | P17T-E | Human | Esophagus | ESCC | 6.27e-04 | 1.61e-01 | 0.1278 |
84131 | CEP78 | P21T-E | Human | Esophagus | ESCC | 3.80e-19 | 3.23e-01 | 0.1617 |
84131 | CEP78 | P22T-E | Human | Esophagus | ESCC | 8.24e-12 | 1.77e-01 | 0.1236 |
84131 | CEP78 | P23T-E | Human | Esophagus | ESCC | 3.62e-10 | 1.85e-01 | 0.108 |
84131 | CEP78 | P24T-E | Human | Esophagus | ESCC | 4.15e-12 | 1.94e-01 | 0.1287 |
84131 | CEP78 | P26T-E | Human | Esophagus | ESCC | 3.37e-10 | 2.01e-01 | 0.1276 |
84131 | CEP78 | P27T-E | Human | Esophagus | ESCC | 2.32e-13 | 2.62e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP78 | SNV | Missense_Mutation | c.1612N>T | p.Leu538Phe | p.L538F | Q5JTW2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CEP78 | SNV | Missense_Mutation | novel | c.407N>C | p.Asp136Ala | p.D136A | Q5JTW2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP78 | SNV | Missense_Mutation | rs756662244 | c.1657A>G | p.Ile553Val | p.I553V | Q5JTW2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
CEP78 | SNV | Missense_Mutation | rs756662244 | c.1657N>G | p.Ile553Val | p.I553V | Q5JTW2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-BH-A0HU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
CEP78 | SNV | Missense_Mutation | c.1744N>A | p.Glu582Lys | p.E582K | Q5JTW2 | protein_coding | tolerated(0.11) | possibly_damaging(0.814) | TCGA-BH-A18U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CEP78 | SNV | Missense_Mutation | c.563N>C | p.Leu188Pro | p.L188P | Q5JTW2 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-E2-A156-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
CEP78 | SNV | Missense_Mutation | rs756662244 | c.1657N>G | p.Ile553Val | p.I553V | Q5JTW2 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-EW-A1J3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
CEP78 | insertion | Nonsense_Mutation | novel | c.2159_2160insTATTCTATAA | p.His721IlefsTer3 | p.H721Ifs*3 | Q5JTW2 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CEP78 | SNV | Missense_Mutation | rs763394651 | c.2027N>T | p.Ala676Val | p.A676V | Q5JTW2 | protein_coding | tolerated_low_confidence(0.59) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CEP78 | SNV | Missense_Mutation | c.2078G>A | p.Ser693Asn | p.S693N | Q5JTW2 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.997) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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