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Gene: CEP41 |
Gene summary for CEP41 |
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Gene information | Species | Human | Gene symbol | CEP41 | Gene ID | 95681 |
Gene name | centrosomal protein 41 | |
Gene Alias | JBTS15 | |
Cytomap | 7q32.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9BYV8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
95681 | CEP41 | LZE24T | Human | Esophagus | ESCC | 8.15e-07 | 2.70e-01 | 0.0596 |
95681 | CEP41 | LZE6T | Human | Esophagus | ESCC | 1.51e-03 | 1.83e-01 | 0.0845 |
95681 | CEP41 | P2T-E | Human | Esophagus | ESCC | 3.03e-06 | 1.38e-01 | 0.1177 |
95681 | CEP41 | P4T-E | Human | Esophagus | ESCC | 3.83e-13 | 2.64e-01 | 0.1323 |
95681 | CEP41 | P5T-E | Human | Esophagus | ESCC | 9.01e-08 | 2.25e-01 | 0.1327 |
95681 | CEP41 | P8T-E | Human | Esophagus | ESCC | 5.16e-09 | 1.62e-01 | 0.0889 |
95681 | CEP41 | P12T-E | Human | Esophagus | ESCC | 4.78e-13 | 2.00e-01 | 0.1122 |
95681 | CEP41 | P15T-E | Human | Esophagus | ESCC | 2.52e-13 | 3.60e-01 | 0.1149 |
95681 | CEP41 | P16T-E | Human | Esophagus | ESCC | 4.34e-10 | 1.82e-01 | 0.1153 |
95681 | CEP41 | P21T-E | Human | Esophagus | ESCC | 4.25e-09 | 2.14e-01 | 0.1617 |
95681 | CEP41 | P22T-E | Human | Esophagus | ESCC | 1.29e-07 | 1.72e-01 | 0.1236 |
95681 | CEP41 | P24T-E | Human | Esophagus | ESCC | 4.91e-06 | 1.54e-01 | 0.1287 |
95681 | CEP41 | P26T-E | Human | Esophagus | ESCC | 4.28e-03 | 8.28e-02 | 0.1276 |
95681 | CEP41 | P27T-E | Human | Esophagus | ESCC | 6.96e-06 | 1.41e-01 | 0.1055 |
95681 | CEP41 | P28T-E | Human | Esophagus | ESCC | 3.63e-05 | 1.11e-01 | 0.1149 |
95681 | CEP41 | P30T-E | Human | Esophagus | ESCC | 1.83e-06 | 2.08e-01 | 0.137 |
95681 | CEP41 | P31T-E | Human | Esophagus | ESCC | 1.67e-09 | 1.59e-01 | 0.1251 |
95681 | CEP41 | P32T-E | Human | Esophagus | ESCC | 5.10e-24 | 5.10e-01 | 0.1666 |
95681 | CEP41 | P36T-E | Human | Esophagus | ESCC | 2.31e-07 | 1.57e-01 | 0.1187 |
95681 | CEP41 | P37T-E | Human | Esophagus | ESCC | 4.04e-03 | 1.18e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEP41 | SNV | Missense_Mutation | rs782089459 | c.1028G>A | p.Arg343Gln | p.R343Q | Q9BYV8 | protein_coding | deleterious(0.03) | benign(0.441) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CEP41 | SNV | Missense_Mutation | c.676N>A | p.Asp226Asn | p.D226N | Q9BYV8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1FC-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEP41 | SNV | Missense_Mutation | c.349G>A | p.Glu117Lys | p.E117K | Q9BYV8 | protein_coding | tolerated(0.53) | benign(0.079) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
CEP41 | SNV | Missense_Mutation | rs138907207 | c.130N>A | p.Glu44Lys | p.E44K | Q9BYV8 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-FU-A3NI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CEP41 | SNV | Missense_Mutation | c.670N>G | p.Leu224Val | p.L224V | Q9BYV8 | protein_coding | tolerated(0.67) | benign(0.078) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
CEP41 | SNV | Missense_Mutation | novel | c.584N>G | p.Tyr195Cys | p.Y195C | Q9BYV8 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CEP41 | SNV | Missense_Mutation | c.900G>T | p.Trp300Cys | p.W300C | Q9BYV8 | protein_coding | tolerated(0.18) | benign(0.119) | TCGA-AA-3941-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CEP41 | SNV | Missense_Mutation | c.935N>G | p.Tyr312Cys | p.Y312C | Q9BYV8 | protein_coding | tolerated(0.17) | benign(0) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CEP41 | SNV | Missense_Mutation | c.160N>C | p.Lys54Gln | p.K54Q | Q9BYV8 | protein_coding | deleterious(0.03) | possibly_damaging(0.527) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CEP41 | SNV | Missense_Mutation | c.391G>A | p.Ala131Thr | p.A131T | Q9BYV8 | protein_coding | tolerated(0.19) | benign(0.006) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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