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Gene: CENPU |
Gene summary for CENPU |
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Gene information | Species | Human | Gene symbol | CENPU | Gene ID | 79682 |
Gene name | centromere protein U | |
Gene Alias | CENP50 | |
Cytomap | 4q35.1 | |
Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q71F23 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79682 | CENPU | P1T-E | Human | Esophagus | ESCC | 1.07e-02 | 3.67e-01 | 0.0875 |
79682 | CENPU | P2T-E | Human | Esophagus | ESCC | 2.86e-26 | 7.60e-01 | 0.1177 |
79682 | CENPU | P4T-E | Human | Esophagus | ESCC | 1.08e-04 | 1.95e-01 | 0.1323 |
79682 | CENPU | P5T-E | Human | Esophagus | ESCC | 1.75e-25 | 5.33e-01 | 0.1327 |
79682 | CENPU | P8T-E | Human | Esophagus | ESCC | 4.12e-11 | 3.67e-01 | 0.0889 |
79682 | CENPU | P10T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.87e-01 | 0.116 |
79682 | CENPU | P12T-E | Human | Esophagus | ESCC | 1.53e-19 | 3.81e-01 | 0.1122 |
79682 | CENPU | P15T-E | Human | Esophagus | ESCC | 3.26e-10 | 4.75e-01 | 0.1149 |
79682 | CENPU | P16T-E | Human | Esophagus | ESCC | 3.60e-13 | 3.09e-01 | 0.1153 |
79682 | CENPU | P17T-E | Human | Esophagus | ESCC | 6.90e-04 | 2.23e-01 | 0.1278 |
79682 | CENPU | P21T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.25e-01 | 0.1617 |
79682 | CENPU | P22T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.83e-01 | 0.1236 |
79682 | CENPU | P23T-E | Human | Esophagus | ESCC | 9.33e-25 | 9.35e-01 | 0.108 |
79682 | CENPU | P24T-E | Human | Esophagus | ESCC | 1.85e-18 | 3.94e-01 | 0.1287 |
79682 | CENPU | P26T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.29e-01 | 0.1276 |
79682 | CENPU | P27T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.06e-01 | 0.1055 |
79682 | CENPU | P28T-E | Human | Esophagus | ESCC | 8.08e-19 | 3.73e-01 | 0.1149 |
79682 | CENPU | P30T-E | Human | Esophagus | ESCC | 1.03e-04 | 5.65e-01 | 0.137 |
79682 | CENPU | P31T-E | Human | Esophagus | ESCC | 1.35e-23 | 7.32e-01 | 0.1251 |
79682 | CENPU | P32T-E | Human | Esophagus | ESCC | 5.95e-29 | 7.51e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CENPU | SNV | Missense_Mutation | novel | c.1102N>G | p.Tyr368Asp | p.Y368D | Q71F23 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
CENPU | insertion | Nonsense_Mutation | novel | c.1103_1104insAA | p.Tyr368Ter | p.Y368* | Q71F23 | protein_coding | TCGA-A7-A26I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
CENPU | insertion | Frame_Shift_Ins | novel | c.129_130insACGTG | p.Phe44ThrfsTer80 | p.F44Tfs*80 | Q71F23 | protein_coding | TCGA-C8-A131-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
CENPU | SNV | Missense_Mutation | c.945N>T | p.Lys315Asn | p.K315N | Q71F23 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CENPU | SNV | Missense_Mutation | rs200975207 | c.1132N>A | p.Val378Ile | p.V378I | Q71F23 | protein_coding | tolerated(0.23) | benign(0) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CENPU | SNV | Missense_Mutation | c.77G>T | p.Arg26Ile | p.R26I | Q71F23 | protein_coding | deleterious(0) | possibly_damaging(0.548) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
CENPU | SNV | Missense_Mutation | c.955N>T | p.Arg319Cys | p.R319C | Q71F23 | protein_coding | deleterious(0.05) | benign(0.3) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CENPU | SNV | Missense_Mutation | c.439A>G | p.Thr147Ala | p.T147A | Q71F23 | protein_coding | tolerated(0.06) | benign(0.061) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
CENPU | SNV | Missense_Mutation | novel | c.527N>G | p.Lys176Arg | p.K176R | Q71F23 | protein_coding | tolerated(0.14) | benign(0.031) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CENPU | SNV | Missense_Mutation | novel | c.317N>T | p.Arg106Ile | p.R106I | Q71F23 | protein_coding | tolerated(0.09) | benign(0.276) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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