![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CENPM |
Gene summary for CENPM |
![]() |
Gene information | Species | Human | Gene symbol | CENPM | Gene ID | 79019 |
Gene name | centromere protein M | |
Gene Alias | C22orf18 | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000775 | UniProtAcc | Q9NSP4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79019 | CENPM | LZE2T | Human | Esophagus | ESCC | 9.06e-03 | 5.09e-01 | 0.082 |
79019 | CENPM | LZE7T | Human | Esophagus | ESCC | 4.77e-02 | 2.78e-01 | 0.0667 |
79019 | CENPM | LZE22T | Human | Esophagus | ESCC | 8.28e-04 | 4.10e-01 | 0.068 |
79019 | CENPM | LZE24T | Human | Esophagus | ESCC | 5.45e-07 | 2.86e-01 | 0.0596 |
79019 | CENPM | LZE21T | Human | Esophagus | ESCC | 1.21e-03 | 5.23e-01 | 0.0655 |
79019 | CENPM | LZE6T | Human | Esophagus | ESCC | 2.21e-05 | 3.05e-01 | 0.0845 |
79019 | CENPM | P1T-E | Human | Esophagus | ESCC | 4.50e-07 | 3.93e-01 | 0.0875 |
79019 | CENPM | P2T-E | Human | Esophagus | ESCC | 1.53e-19 | 5.01e-01 | 0.1177 |
79019 | CENPM | P4T-E | Human | Esophagus | ESCC | 2.23e-22 | 6.34e-01 | 0.1323 |
79019 | CENPM | P5T-E | Human | Esophagus | ESCC | 4.19e-25 | 6.48e-01 | 0.1327 |
79019 | CENPM | P8T-E | Human | Esophagus | ESCC | 2.02e-06 | 1.67e-01 | 0.0889 |
79019 | CENPM | P9T-E | Human | Esophagus | ESCC | 9.01e-07 | 2.41e-01 | 0.1131 |
79019 | CENPM | P10T-E | Human | Esophagus | ESCC | 2.93e-15 | 4.54e-01 | 0.116 |
79019 | CENPM | P12T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.07e-01 | 0.1122 |
79019 | CENPM | P15T-E | Human | Esophagus | ESCC | 8.35e-07 | 2.95e-01 | 0.1149 |
79019 | CENPM | P16T-E | Human | Esophagus | ESCC | 3.28e-14 | 4.21e-01 | 0.1153 |
79019 | CENPM | P17T-E | Human | Esophagus | ESCC | 5.60e-05 | 4.23e-01 | 0.1278 |
79019 | CENPM | P21T-E | Human | Esophagus | ESCC | 1.13e-16 | 3.80e-01 | 0.1617 |
79019 | CENPM | P22T-E | Human | Esophagus | ESCC | 1.13e-16 | 5.09e-01 | 0.1236 |
79019 | CENPM | P23T-E | Human | Esophagus | ESCC | 3.60e-10 | 3.57e-01 | 0.108 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CENPM | insertion | Frame_Shift_Ins | novel | c.282_283insAGGGGTAGGAAAGTAGCCTTTTT | p.Gly95ArgfsTer32 | p.G95Rfs*32 | Q9NSP4 | protein_coding | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
CENPM | SNV | Missense_Mutation | c.5C>T | p.Ser2Leu | p.S2L | Q9NSP4 | protein_coding | deleterious(0) | possibly_damaging(0.577) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
CENPM | SNV | Missense_Mutation | rs763500522 | c.256N>T | p.Arg86Cys | p.R86C | Q9NSP4 | protein_coding | tolerated(0.21) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CENPM | SNV | Missense_Mutation | novel | c.382N>A | p.Leu128Met | p.L128M | Q9NSP4 | protein_coding | tolerated(0.05) | possibly_damaging(0.876) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CENPM | SNV | Missense_Mutation | novel | c.460G>A | p.Ala154Thr | p.A154T | Q9NSP4 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
CENPM | SNV | Missense_Mutation | novel | c.149N>C | p.Lys50Thr | p.K50T | Q9NSP4 | protein_coding | tolerated(0.78) | benign(0.026) | TCGA-EO-A3AV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
CENPM | SNV | Missense_Mutation | novel | c.404T>G | p.Val135Gly | p.V135G | Q9NSP4 | protein_coding | tolerated(0.09) | benign(0.125) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CENPM | SNV | Missense_Mutation | rs528182327 | c.61G>T | p.Val21Leu | p.V21L | Q9NSP4 | protein_coding | tolerated(0.07) | benign(0.048) | TCGA-NC-A5HL-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CENPM | SNV | Missense_Mutation | novel | c.217N>T | p.His73Tyr | p.H73Y | Q9NSP4 | protein_coding | deleterious(0.05) | probably_damaging(0.966) | TCGA-CV-A6K2-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |