Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CENPA

Gene summary for CENPA

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CENPA

Gene ID

1058

Gene namecentromere protein A
Gene AliasCENP-A
Cytomap2p23.3
Gene Typeprotein-coding
GO ID

GO:0000132

UniProtAcc

P49450


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
1058CENPAP2T-EHumanEsophagusESCC4.30e-107.63e-010.1177
1058CENPAP4T-EHumanEsophagusESCC2.11e-116.63e-010.1323
1058CENPAP5T-EHumanEsophagusESCC9.67e-184.51e-010.1327
1058CENPAP9T-EHumanEsophagusESCC2.41e-062.59e-010.1131
1058CENPAP10T-EHumanEsophagusESCC9.53e-095.27e-010.116
1058CENPAP15T-EHumanEsophagusESCC1.35e-042.68e-010.1149
1058CENPAP16T-EHumanEsophagusESCC1.66e-021.38e-010.1153
1058CENPAP17T-EHumanEsophagusESCC4.79e-043.00e-010.1278
1058CENPAP20T-EHumanEsophagusESCC5.73e-032.74e-010.1124
1058CENPAP21T-EHumanEsophagusESCC9.02e-115.05e-010.1617
1058CENPAP22T-EHumanEsophagusESCC4.31e-063.72e-010.1236
1058CENPAP24T-EHumanEsophagusESCC4.16e-227.20e-010.1287
1058CENPAP26T-EHumanEsophagusESCC4.31e-063.07e-010.1276
1058CENPAP28T-EHumanEsophagusESCC4.40e-092.96e-010.1149
1058CENPAP30T-EHumanEsophagusESCC1.02e-022.55e-010.137
1058CENPAP31T-EHumanEsophagusESCC9.56e-083.83e-010.1251
1058CENPAP32T-EHumanEsophagusESCC4.12e-113.88e-010.1666
1058CENPAP36T-EHumanEsophagusESCC2.11e-033.11e-010.1187
1058CENPAP37T-EHumanEsophagusESCC1.22e-134.94e-010.1371
1058CENPAP38T-EHumanEsophagusESCC2.58e-106.89e-010.127
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005165617EsophagusESCCestablishment of organelle localization273/8552390/187239.13e-231.81e-20273
GO:190285015EsophagusESCCmicrotubule cytoskeleton organization involved in mitosis116/8552147/187231.25e-169.91e-15116
GO:000028115EsophagusESCCmitotic cytokinesis58/855271/187234.34e-101.15e-0858
GO:000716320EsophagusESCCestablishment or maintenance of cell polarity143/8552218/187232.05e-094.65e-08143
GO:003450211EsophagusESCCprotein localization to chromosome70/855292/187232.54e-095.64e-0870
GO:000091016EsophagusESCCcytokinesis115/8552173/187232.48e-084.68e-07115
GO:006164015EsophagusESCCcytoskeleton-dependent cytokinesis72/8552100/187238.10e-081.39e-0672
GO:003001018EsophagusESCCestablishment of cell polarity96/8552143/187231.69e-072.67e-0696
GO:00513831EsophagusESCCkinetochore organization21/855223/187235.69e-065.90e-0521
GO:00345081EsophagusESCCcentromere complex assembly25/855230/187232.45e-052.09e-0425
GO:00513821EsophagusESCCkinetochore assembly16/855218/187231.78e-041.15e-0316
GO:0000132EsophagusESCCestablishment of mitotic spindle orientation23/855230/187235.47e-043.00e-0323
GO:00400011EsophagusESCCestablishment of mitotic spindle localization26/855235/187235.57e-043.04e-0326
GO:00512941EsophagusESCCestablishment of spindle orientation27/855237/187237.00e-043.66e-0327
GO:00516533EsophagusESCCspindle localization37/855256/187231.65e-037.65e-0337
GO:0051293EsophagusESCCestablishment of spindle localization33/855251/187234.77e-031.85e-0233
GO:00714591EsophagusESCCprotein localization to chromosome, centromeric region18/855225/187237.04e-032.56e-0218
GO:005165610Oral cavityOSCCestablishment of organelle localization239/7305390/187232.46e-193.31e-17239
GO:19028506Oral cavityOSCCmicrotubule cytoskeleton organization involved in mitosis99/7305147/187232.94e-121.18e-1099
GO:000716318Oral cavityOSCCestablishment or maintenance of cell polarity129/7305218/187231.16e-092.86e-08129
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CENPASNVMissense_Mutationc.238C>Tp.Arg80Cysp.R80CP49450protein_codingtolerated(0.05)benign(0.054)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
CENPASNVMissense_Mutationnovelc.203N>Ap.Ser68Asnp.S68NP49450protein_codingdeleterious(0.01)possibly_damaging(0.787)TCGA-A6-3809-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
CENPASNVMissense_Mutationnovelc.107N>Tp.Ser36Phep.S36FP49450protein_codingtolerated(0.14)benign(0.28)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
CENPASNVMissense_Mutationnovelc.205C>Tp.Arg69Cysp.R69CP49450protein_codingdeleterious(0.02)probably_damaging(0.99)TCGA-DF-A2KU-01Endometriumuterine corpus endometrioid carcinomaFemaleUnknownI/IIUnknownUnknownSD
CENPASNVMissense_Mutationnovelc.184A>Gp.Ile62Valp.I62VP49450protein_codingdeleterious(0.04)benign(0.238)TCGA-DD-AACH-01Liverliver hepatocellular carcinomaMale>=65I/IIUnknownUnknownPD
CENPASNVMissense_Mutationnovelc.205N>Tp.Arg69Cysp.R69CP49450protein_codingdeleterious(0.02)probably_damaging(0.99)TCGA-78-8640-01Lunglung adenocarcinomaMale<65I/IIUnknownUnknownSD
CENPASNVMissense_Mutationnovelc.206N>Tp.Arg69Leup.R69LP49450protein_codingtolerated(0.06)benign(0.231)TCGA-78-8640-01Lunglung adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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