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Gene: CELA3B |
Gene summary for CELA3B |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CELA3B | Gene ID | 23436 |
| Gene name | chymotrypsin like elastase 3B | |
| Gene Alias | CBPP | |
| Cytomap | 1p36.12 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | P08861 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23436 | CELA3B | HTA12-15-2 | Human | Pancreas | PDAC | 6.26e-47 | -2.43e+00 | 0.2315 |
| 23436 | CELA3B | HTA12-23-1 | Human | Pancreas | PDAC | 3.22e-33 | -2.43e+00 | 0.3405 |
| 23436 | CELA3B | HTA12-25-1 | Human | Pancreas | PDAC | 4.45e-46 | -2.43e+00 | 0.313 |
| 23436 | CELA3B | HTA12-26-1 | Human | Pancreas | PDAC | 4.65e-55 | -2.43e+00 | 0.3728 |
| 23436 | CELA3B | HTA12-29-1 | Human | Pancreas | PDAC | 5.13e-124 | -2.43e+00 | 0.3722 |
| 23436 | CELA3B | HTA12-3-16 | Human | Pancreas | PDAC | 4.67e-14 | -2.30e+00 | 0.1553 |
| 23436 | CELA3B | HTA12-30-1 | Human | Pancreas | PDAC | 5.33e-13 | -2.43e+00 | 0.3671 |
| 23436 | CELA3B | HTA12-32-1 | Human | Pancreas | PDAC | 1.34e-16 | -2.04e+00 | 0.3624 |
| 23436 | CELA3B | HTA12-9-1 | Human | Pancreas | PDAC | 2.52e-70 | -2.35e+00 | 0.1532 |
| 23436 | CELA3B | HTA12-9-2 | Human | Pancreas | PDAC | 1.84e-15 | -3.91e-01 | 0.0835 |
| 23436 | CELA3B | HTA12-9-3 | Human | Pancreas | PDAC | 5.86e-39 | -2.43e+00 | 0.2045 |
| 23436 | CELA3B | 3829-EC | Human | Pancreas | PanIN | 4.33e-07 | -1.30e-01 | 0.009 |
| 23436 | CELA3B | 4347-EC | Human | Pancreas | PanIN | 1.97e-06 | -1.43e-01 | 0.0572 |
| 23436 | CELA3B | 4741-EC2 | Human | Pancreas | PanIN | 2.23e-16 | 1.31e-01 | 0.0194 |
| 23436 | CELA3B | 181429 | Human | Pancreas | PDAC | 1.57e-21 | -2.43e+00 | 0.1416 |
| 23436 | CELA3B | 61354830 | Human | Pancreas | PDAC | 5.33e-13 | -2.43e+00 | 0.1458 |
| 23436 | CELA3B | DS20191261Tumor | Human | Pancreas | PDAC | 1.13e-84 | -2.43e+00 | 0.1367 |
| 23436 | CELA3B | DS20191261TumorKeller | Human | Pancreas | PDAC | 4.66e-27 | -2.43e+00 | 0.1407 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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