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Gene: CELA2A |
Gene summary for CELA2A |
Gene summary. |
Gene information | Species | Human | Gene symbol | CELA2A | Gene ID | 63036 |
Gene name | chymotrypsin like elastase 2A | |
Gene Alias | AOMS4 | |
Cytomap | 1p36.21 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P08217 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
63036 | CELA2A | HTA12-15-2 | Human | Pancreas | PDAC | 5.32e-23 | -1.93e+00 | 0.2315 |
63036 | CELA2A | HTA12-16-5 | Human | Pancreas | PDAC | 2.32e-16 | 4.82e-01 | 0.047 |
63036 | CELA2A | HTA12-23-1 | Human | Pancreas | PDAC | 7.21e-15 | -1.93e+00 | 0.3405 |
63036 | CELA2A | HTA12-25-1 | Human | Pancreas | PDAC | 1.76e-22 | -1.93e+00 | 0.313 |
63036 | CELA2A | HTA12-26-1 | Human | Pancreas | PDAC | 4.84e-28 | -1.93e+00 | 0.3728 |
63036 | CELA2A | HTA12-29-1 | Human | Pancreas | PDAC | 3.94e-75 | -1.93e+00 | 0.3722 |
63036 | CELA2A | HTA12-3-16 | Human | Pancreas | PDAC | 2.55e-03 | -1.93e+00 | 0.1553 |
63036 | CELA2A | HTA12-30-1 | Human | Pancreas | PDAC | 5.67e-04 | -1.93e+00 | 0.3671 |
63036 | CELA2A | HTA12-32-1 | Human | Pancreas | PDAC | 1.59e-06 | -1.93e+00 | 0.3624 |
63036 | CELA2A | HTA12-9-1 | Human | Pancreas | PDAC | 1.79e-37 | -1.84e+00 | 0.1532 |
63036 | CELA2A | HTA12-9-3 | Human | Pancreas | PDAC | 3.28e-18 | -1.93e+00 | 0.2045 |
63036 | CELA2A | 3829-EC | Human | Pancreas | PanIN | 3.02e-37 | -9.33e-01 | 0.009 |
63036 | CELA2A | 4347-EC | Human | Pancreas | PanIN | 5.61e-04 | -1.53e-01 | 0.0572 |
63036 | CELA2A | 4741-EC2 | Human | Pancreas | PanIN | 1.41e-15 | 2.75e-01 | 0.0194 |
63036 | CELA2A | 181429 | Human | Pancreas | PDAC | 2.20e-08 | -1.93e+00 | 0.1416 |
63036 | CELA2A | 61354830 | Human | Pancreas | PDAC | 5.67e-04 | -1.93e+00 | 0.1458 |
63036 | CELA2A | DS20191261Tumor | Human | Pancreas | PDAC | 1.78e-47 | -1.93e+00 | 0.1367 |
63036 | CELA2A | DS20191261TumorKeller | Human | Pancreas | PDAC | 2.15e-11 | -1.93e+00 | 0.1407 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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