Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CEBPZ

Gene summary for CEBPZ

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CEBPZ

Gene ID

10153

Gene nameCCAAT enhancer binding protein zeta
Gene AliasCBF
Cytomap2p22.2
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q03701


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
10153CEBPZLZE4THumanEsophagusESCC9.17e-164.77e-010.0811
10153CEBPZLZE7THumanEsophagusESCC1.37e-074.45e-010.0667
10153CEBPZLZE8THumanEsophagusESCC2.76e-095.90e-020.067
10153CEBPZLZE22THumanEsophagusESCC1.66e-022.65e-010.068
10153CEBPZLZE24THumanEsophagusESCC2.69e-113.86e-010.0596
10153CEBPZLZE21THumanEsophagusESCC8.65e-083.26e-010.0655
10153CEBPZLZE6THumanEsophagusESCC5.01e-033.12e-030.0845
10153CEBPZP1T-EHumanEsophagusESCC1.78e-103.84e-010.0875
10153CEBPZP2T-EHumanEsophagusESCC2.02e-165.11e-010.1177
10153CEBPZP4T-EHumanEsophagusESCC2.07e-185.93e-010.1323
10153CEBPZP5T-EHumanEsophagusESCC7.94e-153.48e-010.1327
10153CEBPZP8T-EHumanEsophagusESCC1.75e-134.03e-010.0889
10153CEBPZP9T-EHumanEsophagusESCC3.49e-174.43e-010.1131
10153CEBPZP10T-EHumanEsophagusESCC7.12e-266.84e-010.116
10153CEBPZP11T-EHumanEsophagusESCC8.03e-125.00e-010.1426
10153CEBPZP12T-EHumanEsophagusESCC5.12e-215.20e-010.1122
10153CEBPZP15T-EHumanEsophagusESCC4.42e-244.75e-010.1149
10153CEBPZP16T-EHumanEsophagusESCC4.44e-254.18e-010.1153
10153CEBPZP17T-EHumanEsophagusESCC4.21e-083.15e-010.1278
10153CEBPZP20T-EHumanEsophagusESCC3.12e-233.62e-010.1124
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
CEBPZINCAFColorectumCRCZMAT3,SMIM14,ANKRD28, etc.4.64e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZINCAFColorectumFAPZMAT3,SMIM14,ANKRD28, etc.1.23e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZINCAFColorectumHealthyZMAT3,SMIM14,ANKRD28, etc.1.53e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZAT2LLungAAHCYP2J2,RSAD2,KTI12, etc.2.16e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZAT2LungAAHCYP2J2,RSAD2,KTI12, etc.4.19e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZAT2LungADJCYP2J2,RSAD2,KTI12, etc.3.31e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZAT2LungMIACCYP2J2,RSAD2,KTI12, etc.2.71e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZTFHLungMIACC12orf43,DMAP1,ZNF709, etc.1.59e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZADIPOSkinADJSYS1,GABPA,TFAP4, etc.1.86e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
CEBPZMYOFIBSkincSCCSYS1,GABPA,TFAP4, etc.1.80e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CEBPZSNVMissense_Mutationc.1477N>Tp.Ala493Serp.A493SQ03701protein_codingdeleterious(0)probably_damaging(0.999)TCGA-A2-A25C-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereSD
CEBPZSNVMissense_Mutationc.1477G>Tp.Ala493Serp.A493SQ03701protein_codingdeleterious(0)probably_damaging(0.999)TCGA-E2-A1B6-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificAdriamycinSD
CEBPZSNVMissense_Mutationc.335N>Gp.Asn112Serp.N112SQ03701protein_codingtolerated(0.52)benign(0)TCGA-GM-A2DB-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxolCR
CEBPZSNVMissense_Mutationnovelc.2228C>Tp.Ser743Leup.S743LQ03701protein_codingdeleterious(0.01)benign(0.164)TCGA-GM-A5PX-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexCR
CEBPZinsertionFrame_Shift_Insnovelc.600_601insTATGCAATTTGCTTTTTAAATCAAATGGCTCTGTCCCATGAAGp.Val201TyrfsTer18p.V201Yfs*18Q03701protein_codingTCGA-AO-A0JB-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
CEBPZdeletionFrame_Shift_Delrs763090473c.1428delNp.Asp477MetfsTer11p.D477Mfs*11Q03701protein_codingTCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
CEBPZSNVMissense_Mutationnovelc.1132N>Ap.Glu378Lysp.E378KQ03701protein_codingdeleterious(0)probably_damaging(0.992)TCGA-C5-A1M6-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
CEBPZSNVMissense_Mutationrs372639283c.2485N>Tp.Arg829Trpp.R829WQ03701protein_codingdeleterious(0.02)possibly_damaging(0.852)TCGA-EA-A3HS-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CEBPZSNVMissense_Mutationnovelc.392N>Ap.Ser131Asnp.S131NQ03701protein_codingtolerated(0.46)benign(0)TCGA-EA-A3HU-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
CEBPZinsertionFrame_Shift_Insnovelc.3153dupAp.Gln1052ThrfsTer7p.Q1052Tfs*7Q03701protein_codingTCGA-FU-A5XV-01Cervixcervical & endocervical cancerFemale<65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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