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Gene: CEBPD |
Gene summary for CEBPD |
Gene summary. |
Gene information | Species | Human | Gene symbol | CEBPD | Gene ID | 1052 |
Gene name | CCAAT enhancer binding protein delta | |
Gene Alias | C/EBP-delta | |
Cytomap | 8q11.21 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P49716 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1052 | CEBPD | GSM4909281 | Human | Breast | IDC | 1.35e-28 | -7.95e-01 | 0.21 |
1052 | CEBPD | GSM4909285 | Human | Breast | IDC | 4.38e-47 | -1.08e+00 | 0.21 |
1052 | CEBPD | GSM4909286 | Human | Breast | IDC | 7.01e-30 | -9.17e-01 | 0.1081 |
1052 | CEBPD | GSM4909289 | Human | Breast | IDC | 4.99e-04 | -8.27e-01 | 0.1064 |
1052 | CEBPD | GSM4909290 | Human | Breast | IDC | 1.69e-38 | -1.16e+00 | 0.2096 |
1052 | CEBPD | GSM4909291 | Human | Breast | IDC | 2.20e-29 | -1.12e+00 | 0.1753 |
1052 | CEBPD | GSM4909293 | Human | Breast | IDC | 7.76e-14 | -5.89e-01 | 0.1581 |
1052 | CEBPD | GSM4909294 | Human | Breast | IDC | 2.95e-22 | -7.49e-01 | 0.2022 |
1052 | CEBPD | GSM4909296 | Human | Breast | IDC | 3.21e-36 | -9.38e-01 | 0.1524 |
1052 | CEBPD | GSM4909297 | Human | Breast | IDC | 3.20e-48 | -1.12e+00 | 0.1517 |
1052 | CEBPD | GSM4909298 | Human | Breast | IDC | 4.29e-35 | -9.62e-01 | 0.1551 |
1052 | CEBPD | GSM4909299 | Human | Breast | IDC | 8.78e-07 | -4.07e-01 | 0.035 |
1052 | CEBPD | GSM4909301 | Human | Breast | IDC | 3.35e-16 | -6.93e-01 | 0.1577 |
1052 | CEBPD | GSM4909302 | Human | Breast | IDC | 1.45e-18 | -7.80e-01 | 0.1545 |
1052 | CEBPD | GSM4909304 | Human | Breast | IDC | 1.55e-09 | -2.91e-01 | 0.1636 |
1052 | CEBPD | GSM4909305 | Human | Breast | IDC | 1.25e-07 | -4.22e-01 | 0.0436 |
1052 | CEBPD | GSM4909306 | Human | Breast | IDC | 1.91e-23 | -6.86e-01 | 0.1564 |
1052 | CEBPD | GSM4909307 | Human | Breast | IDC | 1.15e-42 | -1.05e+00 | 0.1569 |
1052 | CEBPD | GSM4909308 | Human | Breast | IDC | 5.06e-32 | -1.01e+00 | 0.158 |
1052 | CEBPD | GSM4909309 | Human | Breast | IDC | 4.57e-21 | -8.56e-01 | 0.0483 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CEBPD | SNV | Missense_Mutation | novel | c.629N>G | p.Asp210Gly | p.D210G | P49716 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CEBPD | SNV | Missense_Mutation | novel | c.764C>T | p.Pro255Leu | p.P255L | P49716 | protein_coding | deleterious(0) | benign(0.044) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CEBPD | SNV | Missense_Mutation | novel | c.584N>A | p.Arg195Gln | p.R195Q | P49716 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-QS-A5YR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CEBPD | SNV | Missense_Mutation | novel | c.769C>G | p.Pro257Ala | p.P257A | P49716 | protein_coding | tolerated(1) | benign(0) | TCGA-99-8033-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
CEBPD | SNV | Missense_Mutation | novel | c.127N>T | p.Gly43Cys | p.G43C | P49716 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD |
CEBPD | SNV | Missense_Mutation | novel | c.202N>G | p.Met68Val | p.M68V | P49716 | protein_coding | tolerated(0.1) | benign(0.007) | TCGA-F7-8298-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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