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Gene: CDRT4 |
Gene summary for CDRT4 |
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Gene information | Species | Human | Gene symbol | CDRT4 | Gene ID | 284040 |
Gene name | CMT1A duplicated region transcript 4 | |
Gene Alias | CDRT4 | |
Cytomap | 17p12 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | D3DTT2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284040 | CDRT4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.97e-13 | 2.65e-01 | 0.0155 |
284040 | CDRT4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.32e-08 | 3.00e-01 | -0.1808 |
284040 | CDRT4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.49e-08 | 4.90e-01 | 0.0216 |
284040 | CDRT4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.84e-10 | 3.61e-01 | -0.0811 |
284040 | CDRT4 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.85e-13 | 3.92e-01 | -0.1088 |
284040 | CDRT4 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.70e-30 | 5.68e-01 | -0.1954 |
284040 | CDRT4 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 5.38e-01 | -0.2602 |
284040 | CDRT4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.71e-03 | 3.07e-01 | -0.2196 |
284040 | CDRT4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.34e-03 | 2.02e-01 | -0.1207 |
284040 | CDRT4 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.35e-06 | 2.18e-01 | -0.1526 |
284040 | CDRT4 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.21e-31 | 6.01e-01 | -0.1464 |
284040 | CDRT4 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.89e-27 | 5.27e-01 | -0.1001 |
284040 | CDRT4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.72e-12 | 3.32e-01 | -0.059 |
284040 | CDRT4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.12e-05 | 2.59e-01 | -0.2061 |
284040 | CDRT4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-03 | 2.80e-01 | -0.1462 |
284040 | CDRT4 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.64e-16 | 5.06e-01 | -0.0842 |
284040 | CDRT4 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.20e-07 | 6.31e-01 | -0.00410000000000005 |
284040 | CDRT4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.47e-08 | 3.22e-01 | -0.0179 |
284040 | CDRT4 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.44e-22 | 4.49e-01 | 0.096 |
284040 | CDRT4 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.84e-10 | 5.38e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDRT4 | insertion | In_Frame_Ins | novel | c.122_123insGGCTGAGAGCTCCCAGCTTCTTTCACGAGGGCATGGTGCCGC | p.Lys41_Arg42insAlaGluSerSerGlnLeuLeuSerArgGlyHisGlyAlaAla | p.K41_R42insAESSQLLSRGHGAA | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |||
CDRT4 | insertion | In_Frame_Ins | novel | c.241_242insTGCTCTTGCTCATGCGGAGCTTGGCTAAGAGAAACC | p.Ser81delinsLeuLeuLeuLeuMetArgSerLeuAlaLysArgAsnPro | p.S81delinsLLLLMRSLAKRNP | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
CDRT4 | insertion | Nonsense_Mutation | novel | c.273_274insATGAGATGTAGTAACTTATAGC | p.Asp92MetfsTer7 | p.D92Mfs*7 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
CDRT4 | SNV | Missense_Mutation | rs753693958 | c.212C>T | p.Ser71Phe | p.S71F | protein_coding | tolerated(0.13) | benign(0.029) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
CDRT4 | SNV | Missense_Mutation | c.35N>C | p.Leu12Pro | p.L12P | protein_coding | deleterious(0.03) | benign(0.04) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
CDRT4 | SNV | Missense_Mutation | c.154N>A | p.Leu52Met | p.L52M | protein_coding | tolerated(0.07) | possibly_damaging(0.483) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
CDRT4 | SNV | Missense_Mutation | novel | c.226N>T | p.Pro76Ser | p.P76S | protein_coding | deleterious(0.02) | benign(0.065) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
CDRT4 | SNV | Missense_Mutation | novel | c.359N>G | p.His120Arg | p.H120R | protein_coding | tolerated(0.29) | benign(0) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDRT4 | SNV | Missense_Mutation | rs745848525 | c.341N>C | p.Met114Thr | p.M114T | protein_coding | tolerated(0.24) | benign(0.003) | TCGA-AX-A2IN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
CDRT4 | SNV | Missense_Mutation | novel | c.236G>T | p.Arg79Met | p.R79M | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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