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Gene: CDKL2 |
Gene summary for CDKL2 |
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Gene information | Species | Human | Gene symbol | CDKL2 | Gene ID | 8999 |
Gene name | cyclin dependent kinase like 2 | |
Gene Alias | KKIAMRE | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DH08 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8999 | CDKL2 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 9.10e-04 | 7.72e-01 | -0.1408 |
8999 | CDKL2 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.17e-03 | 7.22e-01 | -0.138 |
8999 | CDKL2 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 5.51e-11 | 5.52e-01 | -0.2116 |
8999 | CDKL2 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 2.25e-08 | 8.15e-01 | -0.1941 |
8999 | CDKL2 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 4.03e-03 | 4.84e-01 | -0.2107 |
8999 | CDKL2 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.81e-06 | 4.20e-01 | -0.2119 |
8999 | CDKL2 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.67e-02 | 5.32e-01 | -0.0296 |
8999 | CDKL2 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.07e-27 | 7.57e-01 | -0.0166 |
8999 | CDKL2 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.21e-32 | 8.31e-01 | -0.0132 |
8999 | CDKL2 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.54e-30 | 8.29e-01 | -0.013 |
8999 | CDKL2 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 2.45e-26 | 7.84e-01 | -0.0121 |
8999 | CDKL2 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 7.18e-05 | 5.21e-01 | -0.0961 |
8999 | CDKL2 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 1.56e-03 | 4.64e-01 | -0.0822 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDKL2 | SNV | Missense_Mutation | novel | c.1708N>T | p.His570Tyr | p.H570Y | protein_coding | deleterious_low_confidence(0) | benign(0.05) | TCGA-BH-A6R8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDKL2 | deletion | Frame_Shift_Del | novel | c.1110delN | p.Asn370LysfsTer19 | p.N370Kfs*19 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | |||
CDKL2 | SNV | Missense_Mutation | c.1259C>T | p.Ser420Phe | p.S420F | protein_coding | tolerated(0.09) | possibly_damaging(0.824) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
CDKL2 | SNV | Missense_Mutation | c.986N>T | p.Ser329Phe | p.S329F | protein_coding | tolerated(0.06) | benign(0.019) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
CDKL2 | SNV | Missense_Mutation | rs755711267 | c.446N>A | p.Arg149Gln | p.R149Q | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDKL2 | SNV | Missense_Mutation | novel | c.47N>A | p.Gly16Glu | p.G16E | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CDKL2 | SNV | Missense_Mutation | novel | c.430N>A | p.Asp144Asn | p.D144N | protein_coding | deleterious(0) | probably_damaging(0.949) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CDKL2 | SNV | Missense_Mutation | c.1080N>C | p.Lys360Asn | p.K360N | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | ||
CDKL2 | SNV | Missense_Mutation | c.222A>C | p.Lys74Asn | p.K74N | protein_coding | deleterious(0) | possibly_damaging(0.805) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
CDKL2 | SNV | Missense_Mutation | c.1127N>A | p.Ser376Asn | p.S376N | protein_coding | tolerated(0.27) | benign(0.011) | TCGA-DM-A28G-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8999 | CDKL2 | DRUGGABLE GENOME, KINASE, ENZYME, TUMOR SUPPRESSOR, SERINE THREONINE KINASE | inhibitor | 249565786 |
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