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Gene: CDH23 |
Gene summary for CDH23 |
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Gene information | Species | Human | Gene symbol | CDH23 | Gene ID | 64072 |
Gene name | cadherin related 23 | |
Gene Alias | CDHR23 | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001894 | UniProtAcc | A0A087WYR8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64072 | CDH23 | HCC1_Meng | Human | Liver | HCC | 3.87e-04 | -3.53e-02 | 0.0246 |
64072 | CDH23 | HCC1 | Human | Liver | HCC | 1.42e-06 | 1.04e+00 | 0.5336 |
64072 | CDH23 | HCC2 | Human | Liver | HCC | 4.65e-11 | 1.22e+00 | 0.5341 |
64072 | CDH23 | HCC5 | Human | Liver | HCC | 3.58e-08 | 1.05e+00 | 0.4932 |
64072 | CDH23 | S029 | Human | Liver | HCC | 8.12e-10 | 4.38e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDH23 | SNV | Missense_Mutation | novel | c.1091N>C | p.Gly364Ala | p.G364A | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A2-A4S1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDH23 | SNV | Missense_Mutation | rs375465342 | c.553N>A | p.Gly185Ser | p.G185S | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A8-A093-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
CDH23 | SNV | Missense_Mutation | rs751682379 | c.2569N>A | p.Val857Ile | p.V857I | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDH23 | SNV | Missense_Mutation | c.3388G>A | p.Asp1130Asn | p.D1130N | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
CDH23 | SNV | Missense_Mutation | rs377148854 | c.1699N>A | p.Val567Met | p.V567M | protein_coding | tolerated(0.14) | benign(0.035) | TCGA-AC-A62X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDH23 | SNV | Missense_Mutation | novel | c.315N>A | p.Phe105Leu | p.F105L | protein_coding | tolerated(0.23) | probably_damaging(0.986) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDH23 | SNV | Missense_Mutation | novel | c.1806N>G | p.Ser602Arg | p.S602R | protein_coding | tolerated(0.31) | benign(0.014) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CDH23 | SNV | Missense_Mutation | rs779553715 | c.8923G>A | p.Gly2975Ser | p.G2975S | protein_coding | tolerated(0.68) | benign(0.03) | TCGA-AO-A0J6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CDH23 | SNV | Missense_Mutation | novel | c.2425N>C | p.Glu809Gln | p.E809Q | protein_coding | tolerated(0.08) | possibly_damaging(0.892) | TCGA-AR-A1AO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
CDH23 | SNV | Missense_Mutation | rs772995621 | c.499G>A | p.Val167Ile | p.V167I | protein_coding | tolerated(0.26) | probably_damaging(0.959) | TCGA-B6-A0I1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
64072 | CDH23 | NA | methylphenidate | METHYLPHENIDATE | 29382897 |
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