Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: CDC42EP5

Gene summary for CDC42EP5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

CDC42EP5

Gene ID

148170

Gene nameCDC42 effector protein 5
Gene AliasBorg3
Cytomap19q13.42
Gene Typeprotein-coding
GO ID

GO:0000165

UniProtAcc

Q6NZY7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
148170CDC42EP5HTA11_2487_2000001011HumanColorectumSER1.32e-159.57e-01-0.1808
148170CDC42EP5HTA11_1938_2000001011HumanColorectumAD1.78e-035.84e-01-0.0811
148170CDC42EP5HTA11_347_2000001011HumanColorectumAD9.85e-311.00e+00-0.1954
148170CDC42EP5HTA11_411_2000001011HumanColorectumSER5.70e-111.49e+00-0.2602
148170CDC42EP5HTA11_2112_2000001011HumanColorectumSER4.34e-071.16e+00-0.2196
148170CDC42EP5HTA11_3361_2000001011HumanColorectumAD3.62e-097.48e-01-0.1207
148170CDC42EP5HTA11_83_2000001011HumanColorectumSER3.51e-025.25e-01-0.1526
148170CDC42EP5HTA11_696_2000001011HumanColorectumAD1.21e-299.48e-01-0.1464
148170CDC42EP5HTA11_866_2000001011HumanColorectumAD9.14e-115.94e-01-0.1001
148170CDC42EP5HTA11_1391_2000001011HumanColorectumAD1.76e-097.13e-01-0.059
148170CDC42EP5HTA11_2992_2000001011HumanColorectumSER1.08e-101.22e+00-0.1706
148170CDC42EP5HTA11_5212_2000001011HumanColorectumAD1.92e-057.86e-01-0.2061
148170CDC42EP5HTA11_5216_2000001011HumanColorectumSER3.10e-037.55e-01-0.1462
148170CDC42EP5HTA11_546_2000001011HumanColorectumAD4.60e-068.49e-01-0.0842
148170CDC42EP5HTA11_10711_2000001011HumanColorectumAD1.21e-025.43e-010.0338
148170CDC42EP5HTA11_7696_3000711011HumanColorectumAD5.25e-054.48e-010.0674
148170CDC42EP5HTA11_99999970781_79442HumanColorectumMSS1.57e-02-3.15e-010.294
148170CDC42EP5HTA11_99999974143_84620HumanColorectumMSS1.95e-10-4.50e-010.3005
148170CDC42EP5F007HumanColorectumFAP1.10e-03-2.67e-010.1176
148170CDC42EP5A001-C-207HumanColorectumFAP5.47e-04-2.25e-010.1278
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0007015ColorectumADactin filament organization167/3918442/187231.65e-167.94e-14167
GO:0032535ColorectumADregulation of cellular component size142/3918383/187231.74e-133.41e-11142
GO:1902903ColorectumADregulation of supramolecular fiber organization139/3918383/187232.01e-123.19e-10139
GO:0032970ColorectumADregulation of actin filament-based process142/3918397/187234.05e-125.90e-10142
GO:0110053ColorectumADregulation of actin filament organization108/3918278/187235.02e-126.98e-10108
GO:0008154ColorectumADactin polymerization or depolymerization90/3918218/187236.14e-128.23e-1090
GO:0032271ColorectumADregulation of protein polymerization94/3918233/187231.01e-111.29e-0994
GO:0030041ColorectumADactin filament polymerization81/3918191/187231.35e-111.69e-0981
GO:0051258ColorectumADprotein polymerization112/3918297/187231.85e-112.27e-09112
GO:0043254ColorectumADregulation of protein-containing complex assembly148/3918428/187232.64e-113.18e-09148
GO:0008064ColorectumADregulation of actin polymerization or depolymerization79/3918188/187234.17e-114.74e-0979
GO:0030833ColorectumADregulation of actin filament polymerization74/3918172/187234.50e-115.03e-0974
GO:0030832ColorectumADregulation of actin filament length79/3918189/187235.71e-116.27e-0979
GO:1902905ColorectumADpositive regulation of supramolecular fiber organization85/3918209/187235.95e-116.33e-0985
GO:0032956ColorectumADregulation of actin cytoskeleton organization127/3918358/187231.03e-101.04e-08127
GO:0051495ColorectumADpositive regulation of cytoskeleton organization89/3918226/187231.61e-101.56e-0889
GO:0032273ColorectumADpositive regulation of protein polymerization62/3918138/187231.94e-101.76e-0862
GO:0031334ColorectumADpositive regulation of protein-containing complex assembly91/3918237/187234.78e-103.99e-0891
GO:0030838ColorectumADpositive regulation of actin filament polymerization48/391899/187239.21e-107.03e-0848
GO:0022604ColorectumADregulation of cell morphogenesis109/3918309/187233.08e-092.07e-07109
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
CDC42EP5SNVMissense_Mutationnovelc.322G>Tp.Asp108Tyrp.D108YQ6NZY7protein_codingdeleterious(0)benign(0.338)TCGA-G3-AAV0-01Liverliver hepatocellular carcinomaMale<65I/IIUnknownUnknownSD
CDC42EP5SNVMissense_Mutationnovelc.259N>Gp.Pro87Alap.P87AQ6NZY7protein_codingtolerated(0.34)possibly_damaging(0.461)TCGA-58-8391-01Lunglung squamous cell carcinomaFemale<65III/IVChemotherapycarboplatinPD
CDC42EP5SNVMissense_Mutationc.432N>Gp.Asp144Glup.D144EQ6NZY7protein_codingtolerated_low_confidence(0.27)benign(0.01)TCGA-66-2793-01Lunglung squamous cell carcinomaMale>=65III/IVUnknownUnknownSD
CDC42EP5SNVMissense_Mutationnovelc.109N>Ap.Gly37Argp.G37RQ6NZY7protein_codingdeleterious(0)probably_damaging(1)TCGA-QU-A6IO-01Prostateprostate adenocarcinomaMale<656UnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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