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Gene: CD200 |
Gene summary for CD200 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CD200 | Gene ID | 4345 |
| Gene name | CD200 molecule | |
| Gene Alias | MOX1 | |
| Cytomap | 3q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | P41217 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4345 | CD200 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.91e-08 | 3.13e-01 | 0.0155 |
| 4345 | CD200 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.98e-07 | 4.78e-01 | -0.1954 |
| 4345 | CD200 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.53e-04 | 2.54e-01 | 0.096 |
| 4345 | CD200 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.21e-03 | 5.99e-01 | 0.0131 |
| 4345 | CD200 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.29e-03 | 2.54e-01 | -0.0177 |
| 4345 | CD200 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.15e-02 | 4.92e-01 | 0.0171 |
| 4345 | CD200 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.28e-15 | 6.86e-01 | 0.294 |
| 4345 | CD200 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.60e-08 | -1.95e-01 | 0.3005 |
| 4345 | CD200 | A015-C-203 | Human | Colorectum | FAP | 1.22e-06 | -1.74e-01 | -0.1294 |
| 4345 | CD200 | A001-C-108 | Human | Colorectum | FAP | 3.00e-03 | -1.36e-01 | -0.0272 |
| 4345 | CD200 | A015-C-104 | Human | Colorectum | FAP | 7.95e-06 | -1.31e-01 | -0.1899 |
| 4345 | CD200 | A002-C-116 | Human | Colorectum | FAP | 9.88e-05 | -1.70e-01 | -0.0452 |
| 4345 | CD200 | F034 | Human | Colorectum | FAP | 5.10e-05 | -1.87e-01 | -0.0665 |
| 4345 | CD200 | F072B | Human | Colorectum | FAP | 2.01e-05 | -1.93e-01 | 0.257 |
| 4345 | CD200 | CRC-1-8810 | Human | Colorectum | CRC | 1.23e-03 | -1.75e-01 | 0.6257 |
| 4345 | CD200 | P2T-E | Human | Esophagus | ESCC | 3.70e-29 | 6.31e-01 | 0.1177 |
| 4345 | CD200 | P10T-E | Human | Esophagus | ESCC | 4.17e-14 | 4.24e-01 | 0.116 |
| 4345 | CD200 | P16T-E | Human | Esophagus | ESCC | 3.18e-18 | 5.44e-01 | 0.1153 |
| 4345 | CD200 | P52T-E | Human | Esophagus | ESCC | 1.66e-05 | 3.24e-01 | 0.1555 |
| 4345 | CD200 | P56T-E | Human | Esophagus | ESCC | 5.74e-07 | 1.10e+00 | 0.1613 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
| GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
| GO:0050708 | Colorectum | AD | regulation of protein secretion | 83/3918 | 268/18723 | 6.59e-05 | 1.07e-03 | 83 |
| GO:1901215 | Colorectum | AD | negative regulation of neuron death | 67/3918 | 208/18723 | 8.81e-05 | 1.35e-03 | 67 |
| GO:0009306 | Colorectum | AD | protein secretion | 105/3918 | 359/18723 | 1.05e-04 | 1.57e-03 | 105 |
| GO:0035592 | Colorectum | AD | establishment of protein localization to extracellular region | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
| GO:0071692 | Colorectum | AD | protein localization to extracellular region | 106/3918 | 368/18723 | 1.86e-04 | 2.49e-03 | 106 |
| GO:0051091 | Colorectum | AD | positive regulation of DNA-binding transcription factor activity | 73/3918 | 260/18723 | 3.52e-03 | 2.54e-02 | 73 |
| GO:0071634 | Colorectum | AD | regulation of transforming growth factor beta production | 16/3918 | 41/18723 | 6.20e-03 | 3.88e-02 | 16 |
| GO:00709971 | Colorectum | SER | neuron death | 84/2897 | 361/18723 | 5.76e-05 | 1.35e-03 | 84 |
| GO:00507081 | Colorectum | SER | regulation of protein secretion | 63/2897 | 268/18723 | 3.42e-04 | 5.39e-03 | 63 |
| GO:00093061 | Colorectum | SER | protein secretion | 79/2897 | 359/18723 | 5.99e-04 | 8.19e-03 | 79 |
| GO:00355921 | Colorectum | SER | establishment of protein localization to extracellular region | 79/2897 | 360/18723 | 6.54e-04 | 8.77e-03 | 79 |
| GO:19012141 | Colorectum | SER | regulation of neuron death | 71/2897 | 319/18723 | 7.95e-04 | 1.00e-02 | 71 |
| GO:00716921 | Colorectum | SER | protein localization to extracellular region | 80/2897 | 368/18723 | 8.13e-04 | 1.01e-02 | 80 |
| GO:0051051 | Colorectum | SER | negative regulation of transport | 98/2897 | 470/18723 | 1.01e-03 | 1.19e-02 | 98 |
| GO:19012151 | Colorectum | SER | negative regulation of neuron death | 49/2897 | 208/18723 | 1.40e-03 | 1.53e-02 | 49 |
| GO:00716341 | Colorectum | SER | regulation of transforming growth factor beta production | 14/2897 | 41/18723 | 2.45e-03 | 2.32e-02 | 14 |
| GO:0071604 | Colorectum | SER | transforming growth factor beta production | 14/2897 | 43/18723 | 4.04e-03 | 3.30e-02 | 14 |
| GO:0071675 | Colorectum | SER | regulation of mononuclear cell migration | 29/2897 | 115/18723 | 4.45e-03 | 3.54e-02 | 29 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CD200 | SNV | Missense_Mutation | novel | c.653N>G | p.Thr218Arg | p.T218R | P41217 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
| CD200 | SNV | Missense_Mutation | novel | c.809N>T | p.Ser270Phe | p.S270F | P41217 | protein_coding | tolerated(0.11) | possibly_damaging(0.837) | TCGA-C5-A7UE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
| CD200 | SNV | Missense_Mutation | c.637N>G | p.His213Asp | p.H213D | P41217 | protein_coding | tolerated(0.07) | benign(0.257) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| CD200 | SNV | Missense_Mutation | novel | c.309N>G | p.Phe103Leu | p.F103L | P41217 | protein_coding | deleterious(0) | benign(0.096) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| CD200 | SNV | Missense_Mutation | c.705N>T | p.Lys235Asn | p.K235N | P41217 | protein_coding | deleterious(0.01) | possibly_damaging(0.668) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| CD200 | SNV | Missense_Mutation | c.35G>C | p.Gly12Ala | p.G12A | P41217 | protein_coding | tolerated_low_confidence(0.71) | benign(0) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CD200 | SNV | Missense_Mutation | rs759192172 | c.745G>A | p.Asp249Asn | p.D249N | P41217 | protein_coding | tolerated(0.18) | benign(0.014) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| CD200 | SNV | Missense_Mutation | novel | c.438N>G | p.Cys146Trp | p.C146W | P41217 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| CD200 | SNV | Missense_Mutation | c.526N>C | p.Phe176Leu | p.F176L | P41217 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-CM-6172-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD | |
| CD200 | SNV | Missense_Mutation | novel | c.823N>T | p.Leu275Phe | p.L275F | P41217 | protein_coding | tolerated(0.09) | probably_damaging(0.996) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 4345 | CD200 | CELL SURFACE, DRUGGABLE GENOME | inhibitor | CHEMBL1743067 | SAMALIZUMAB | |
| 4345 | CD200 | CELL SURFACE, DRUGGABLE GENOME | ALXN6000 | SAMALIZUMAB | 21559315 |
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