![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CCT8 |
Gene summary for CCT8 |
![]() |
Gene information | Species | Human | Gene symbol | CCT8 | Gene ID | 10694 |
Gene name | chaperonin containing TCP1 subunit 8 | |
Gene Alias | C21orf112 | |
Cytomap | 21q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P50990 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10694 | CCT8 | GSM4909280 | Human | Breast | Precancer | 9.43e-03 | -3.17e-01 | 0.0305 |
10694 | CCT8 | GSM4909282 | Human | Breast | IDC | 3.95e-02 | 2.04e-01 | -0.0288 |
10694 | CCT8 | GSM4909285 | Human | Breast | IDC | 8.32e-38 | 6.89e-01 | 0.21 |
10694 | CCT8 | GSM4909286 | Human | Breast | IDC | 5.34e-04 | -2.85e-01 | 0.1081 |
10694 | CCT8 | GSM4909291 | Human | Breast | IDC | 9.15e-06 | -3.95e-01 | 0.1753 |
10694 | CCT8 | GSM4909294 | Human | Breast | IDC | 1.11e-08 | 1.48e-01 | 0.2022 |
10694 | CCT8 | GSM4909296 | Human | Breast | IDC | 1.14e-24 | -5.06e-01 | 0.1524 |
10694 | CCT8 | GSM4909297 | Human | Breast | IDC | 3.68e-18 | -2.13e-01 | 0.1517 |
10694 | CCT8 | GSM4909301 | Human | Breast | IDC | 1.25e-06 | -3.32e-01 | 0.1577 |
10694 | CCT8 | GSM4909302 | Human | Breast | IDC | 9.31e-07 | -3.24e-01 | 0.1545 |
10694 | CCT8 | GSM4909304 | Human | Breast | IDC | 4.46e-04 | -3.50e-01 | 0.1636 |
10694 | CCT8 | GSM4909307 | Human | Breast | IDC | 6.41e-07 | -3.71e-01 | 0.1569 |
10694 | CCT8 | GSM4909309 | Human | Breast | IDC | 8.53e-08 | -3.46e-01 | 0.0483 |
10694 | CCT8 | GSM4909311 | Human | Breast | IDC | 1.25e-31 | -3.91e-01 | 0.1534 |
10694 | CCT8 | GSM4909312 | Human | Breast | IDC | 1.50e-12 | -8.45e-02 | 0.1552 |
10694 | CCT8 | GSM4909313 | Human | Breast | IDC | 6.45e-08 | -3.70e-01 | 0.0391 |
10694 | CCT8 | GSM4909318 | Human | Breast | IDC | 3.41e-03 | -3.41e-01 | 0.2031 |
10694 | CCT8 | GSM4909319 | Human | Breast | IDC | 3.94e-43 | -4.94e-01 | 0.1563 |
10694 | CCT8 | GSM4909320 | Human | Breast | IDC | 3.83e-11 | -5.68e-01 | 0.1575 |
10694 | CCT8 | GSM4909321 | Human | Breast | IDC | 9.43e-18 | -3.57e-01 | 0.1559 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:00508219 | Breast | Precancer | protein stabilization | 29/1080 | 191/18723 | 1.67e-06 | 6.08e-05 | 29 |
GO:00316479 | Breast | Precancer | regulation of protein stability | 38/1080 | 298/18723 | 3.73e-06 | 1.19e-04 | 38 |
GO:00108338 | Breast | Precancer | telomere maintenance via telomere lengthening | 15/1080 | 81/18723 | 5.31e-05 | 1.11e-03 | 15 |
GO:00007238 | Breast | Precancer | telomere maintenance | 20/1080 | 131/18723 | 6.10e-05 | 1.25e-03 | 20 |
GO:19901734 | Breast | Precancer | protein localization to nucleoplasm | 6/1080 | 14/18723 | 7.30e-05 | 1.44e-03 | 6 |
GO:20005738 | Breast | Precancer | positive regulation of DNA biosynthetic process | 13/1080 | 66/18723 | 8.54e-05 | 1.63e-03 | 13 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:19048743 | Breast | Precancer | positive regulation of telomerase RNA localization to Cajal body | 6/1080 | 15/18723 | 1.16e-04 | 2.08e-03 | 6 |
GO:19048516 | Breast | Precancer | positive regulation of establishment of protein localization to telomere | 5/1080 | 10/18723 | 1.25e-04 | 2.21e-03 | 5 |
GO:00070047 | Breast | Precancer | telomere maintenance via telomerase | 13/1080 | 69/18723 | 1.37e-04 | 2.38e-03 | 13 |
GO:19043567 | Breast | Precancer | regulation of telomere maintenance via telomere lengthening | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:19043588 | Breast | Precancer | positive regulation of telomere maintenance via telomere lengthening | 9/1080 | 37/18723 | 1.96e-04 | 3.10e-03 | 9 |
GO:00702034 | Breast | Precancer | regulation of establishment of protein localization to telomere | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:19048694 | Breast | Precancer | regulation of protein localization to Cajal body | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:19048714 | Breast | Precancer | positive regulation of protein localization to Cajal body | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:00062786 | Breast | Precancer | RNA-dependent DNA biosynthetic process | 13/1080 | 75/18723 | 3.27e-04 | 4.64e-03 | 13 |
GO:0035036 | Breast | Precancer | sperm-egg recognition | 10/1080 | 48/18723 | 3.43e-04 | 4.81e-03 | 10 |
GO:00702026 | Breast | Precancer | regulation of establishment of protein localization to chromosome | 5/1080 | 12/18723 | 3.56e-04 | 4.93e-03 | 5 |
GO:19034053 | Breast | Precancer | protein localization to nuclear body | 5/1080 | 12/18723 | 3.56e-04 | 4.93e-03 | 5 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT8 | SNV | Missense_Mutation | c.475N>A | p.Glu159Lys | p.E159K | P50990 | protein_coding | tolerated(0.08) | benign(0.341) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
CCT8 | SNV | Missense_Mutation | c.1204N>G | p.Leu402Val | p.L402V | P50990 | protein_coding | tolerated(0.08) | possibly_damaging(0.493) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
CCT8 | SNV | Missense_Mutation | rs776326374 | c.269C>T | p.Ser90Phe | p.S90F | P50990 | protein_coding | deleterious(0) | possibly_damaging(0.674) | TCGA-AO-A0J2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
CCT8 | SNV | Missense_Mutation | novel | c.1633N>C | p.Asp545His | p.D545H | P50990 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
CCT8 | SNV | Missense_Mutation | c.38N>T | p.Gln13Leu | p.Q13L | P50990 | protein_coding | tolerated(0.2) | benign(0) | TCGA-C8-A1HF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CCT8 | SNV | Missense_Mutation | novel | c.784G>A | p.Ala262Thr | p.A262T | P50990 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A1MQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
CCT8 | SNV | Missense_Mutation | c.553N>G | p.Gln185Glu | p.Q185E | P50990 | protein_coding | tolerated(1) | benign(0) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCT8 | SNV | Missense_Mutation | c.1027N>C | p.Glu343Gln | p.E343Q | P50990 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CCT8 | SNV | Missense_Mutation | c.208N>A | p.Ala70Thr | p.A70T | P50990 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
CCT8 | SNV | Missense_Mutation | c.1525N>G | p.Lys509Glu | p.K509E | P50990 | protein_coding | deleterious(0.02) | possibly_damaging(0.78) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |