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Gene: CCT7 |
Gene summary for CCT7 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCT7 | Gene ID | 10574 |
| Gene name | chaperonin containing TCP1 subunit 7 | |
| Gene Alias | CCTETA | |
| Cytomap | 2p13.2 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q99832 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10574 | CCT7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.74e-17 | 4.82e-01 | 0.0155 |
| 10574 | CCT7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.20e-07 | 4.66e-01 | -0.1808 |
| 10574 | CCT7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.81e-05 | 6.21e-01 | 0.0216 |
| 10574 | CCT7 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.57e-15 | 8.98e-01 | -0.0811 |
| 10574 | CCT7 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.93e-14 | 6.75e-01 | -0.1088 |
| 10574 | CCT7 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.26e-22 | 5.73e-01 | -0.1954 |
| 10574 | CCT7 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.82e-06 | 9.05e-01 | -0.2602 |
| 10574 | CCT7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 5.97e-03 | 7.65e-01 | -0.2196 |
| 10574 | CCT7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.32e-11 | 7.07e-01 | -0.1207 |
| 10574 | CCT7 | HTA11_83_2000001011 | Human | Colorectum | SER | 4.06e-09 | 6.39e-01 | -0.1526 |
| 10574 | CCT7 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.29e-35 | 8.91e-01 | -0.1464 |
| 10574 | CCT7 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.89e-21 | 5.97e-01 | -0.1001 |
| 10574 | CCT7 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.83e-34 | 1.26e+00 | -0.059 |
| 10574 | CCT7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.63e-08 | 7.84e-01 | -0.1706 |
| 10574 | CCT7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.61e-05 | 4.55e-01 | -0.2061 |
| 10574 | CCT7 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.17e-04 | 6.82e-01 | -0.1462 |
| 10574 | CCT7 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.32e-14 | 8.60e-01 | -0.0842 |
| 10574 | CCT7 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.37e-04 | 6.51e-01 | -0.00410000000000005 |
| 10574 | CCT7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.03e-11 | 6.75e-01 | -0.0179 |
| 10574 | CCT7 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.52e-47 | 1.28e+00 | 0.096 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
| GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
| GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
| GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
| GO:1900182 | Colorectum | AD | positive regulation of protein localization to nucleus | 38/3918 | 87/18723 | 1.43e-06 | 4.52e-05 | 38 |
| GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
| GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
| GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
| GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
| GO:2000278 | Colorectum | AD | regulation of DNA biosynthetic process | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
| GO:2000573 | Colorectum | AD | positive regulation of DNA biosynthetic process | 28/3918 | 66/18723 | 6.35e-05 | 1.05e-03 | 28 |
| GO:0032206 | Colorectum | AD | positive regulation of telomere maintenance | 23/3918 | 52/18723 | 1.31e-04 | 1.88e-03 | 23 |
| GO:0032204 | Colorectum | AD | regulation of telomere maintenance | 31/3918 | 80/18723 | 2.01e-04 | 2.67e-03 | 31 |
| GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
| GO:0000723 | Colorectum | AD | telomere maintenance | 43/3918 | 131/18723 | 9.77e-04 | 9.20e-03 | 43 |
| GO:0010833 | Colorectum | AD | telomere maintenance via telomere lengthening | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CCT7 | SNV | Missense_Mutation | novel | c.938G>C | p.Arg313Pro | p.R313P | Q99832 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-A2-A3XV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| CCT7 | SNV | Missense_Mutation | c.667N>C | p.Ala223Pro | p.A223P | Q99832 | protein_coding | tolerated(0.07) | probably_damaging(0.997) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCT7 | SNV | Missense_Mutation | rs541718985 | c.1339N>T | p.Arg447Cys | p.R447C | Q99832 | protein_coding | deleterious(0) | benign(0.12) | TCGA-AR-A1AJ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CCT7 | SNV | Missense_Mutation | novel | c.256N>A | p.Gln86Lys | p.Q86K | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| CCT7 | SNV | Missense_Mutation | novel | c.257N>T | p.Gln86Leu | p.Q86L | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A1FU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
| CCT7 | insertion | Frame_Shift_Ins | novel | c.117_118insT | p.Leu40SerfsTer21 | p.L40Sfs*21 | Q99832 | protein_coding | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| CCT7 | insertion | Frame_Shift_Ins | novel | c.118_119insAAGCTCTTGGCATCTTGCATTT | p.Leu40GlnfsTer28 | p.L40Qfs*28 | Q99832 | protein_coding | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| CCT7 | SNV | Missense_Mutation | novel | c.1242N>C | p.Met414Ile | p.M414I | Q99832 | protein_coding | deleterious(0.04) | possibly_damaging(0.744) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD |
| CCT7 | SNV | Missense_Mutation | c.779N>C | p.Val260Ala | p.V260A | Q99832 | protein_coding | tolerated(0.18) | possibly_damaging(0.672) | TCGA-F5-6811-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCT7 | SNV | Missense_Mutation | novel | c.656N>T | p.Thr219Ile | p.T219I | Q99832 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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