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Gene: CCT6A |
Gene summary for CCT6A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCT6A | Gene ID | 908 |
| Gene name | chaperonin containing TCP1 subunit 6A | |
| Gene Alias | CCT-zeta | |
| Cytomap | 7p11.2 | |
| Gene Type | protein-coding | GO ID | GO:0000723 | UniProtAcc | P40227 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 908 | CCT6A | HTA11_78_2000001011 | Human | Colorectum | AD | 3.85e-04 | 4.43e-01 | -0.1088 |
| 908 | CCT6A | HTA11_347_2000001011 | Human | Colorectum | AD | 2.44e-04 | 3.19e-01 | -0.1954 |
| 908 | CCT6A | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.69e-03 | 4.25e-01 | -0.059 |
| 908 | CCT6A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.80e-02 | 7.36e-01 | 0.0171 |
| 908 | CCT6A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.16e-08 | 5.11e-01 | 0.294 |
| 908 | CCT6A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.45e-06 | 7.16e-01 | 0.281 |
| 908 | CCT6A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.68e-19 | 7.13e-01 | 0.3859 |
| 908 | CCT6A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.95e-03 | 2.84e-01 | 0.3005 |
| 908 | CCT6A | A015-C-203 | Human | Colorectum | FAP | 6.36e-04 | -6.54e-02 | -0.1294 |
| 908 | CCT6A | A001-C-108 | Human | Colorectum | FAP | 2.87e-02 | -7.64e-02 | -0.0272 |
| 908 | CCT6A | A002-C-205 | Human | Colorectum | FAP | 8.09e-04 | -4.90e-02 | -0.1236 |
| 908 | CCT6A | A002-C-114 | Human | Colorectum | FAP | 7.50e-03 | -4.67e-02 | -0.1561 |
| 908 | CCT6A | A015-C-104 | Human | Colorectum | FAP | 3.93e-06 | -8.85e-02 | -0.1899 |
| 908 | CCT6A | A002-C-016 | Human | Colorectum | FAP | 3.78e-02 | -5.99e-02 | 0.0521 |
| 908 | CCT6A | A002-C-116 | Human | Colorectum | FAP | 1.99e-04 | -7.76e-02 | -0.0452 |
| 908 | CCT6A | CRC-3-11773 | Human | Colorectum | CRC | 1.40e-05 | 3.57e-01 | 0.2564 |
| 908 | CCT6A | AEH-subject1 | Human | Endometrium | AEH | 3.73e-08 | -2.48e-01 | -0.3059 |
| 908 | CCT6A | AEH-subject2 | Human | Endometrium | AEH | 1.05e-09 | -2.71e-01 | -0.2525 |
| 908 | CCT6A | AEH-subject3 | Human | Endometrium | AEH | 9.93e-06 | -1.27e-01 | -0.2576 |
| 908 | CCT6A | AEH-subject4 | Human | Endometrium | AEH | 1.77e-02 | -8.85e-02 | -0.2657 |
| Page: 1 2 3 4 5 6 7 8 9 10 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
| GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
| GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
| GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
| GO:1900182 | Colorectum | AD | positive regulation of protein localization to nucleus | 38/3918 | 87/18723 | 1.43e-06 | 4.52e-05 | 38 |
| GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
| GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
| GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
| GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
| GO:2000278 | Colorectum | AD | regulation of DNA biosynthetic process | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
| GO:2000573 | Colorectum | AD | positive regulation of DNA biosynthetic process | 28/3918 | 66/18723 | 6.35e-05 | 1.05e-03 | 28 |
| GO:0032206 | Colorectum | AD | positive regulation of telomere maintenance | 23/3918 | 52/18723 | 1.31e-04 | 1.88e-03 | 23 |
| GO:0032204 | Colorectum | AD | regulation of telomere maintenance | 31/3918 | 80/18723 | 2.01e-04 | 2.67e-03 | 31 |
| GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
| GO:0000723 | Colorectum | AD | telomere maintenance | 43/3918 | 131/18723 | 9.77e-04 | 9.20e-03 | 43 |
| GO:0010833 | Colorectum | AD | telomere maintenance via telomere lengthening | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CCT6A | SNV | Missense_Mutation | rs770231271 | c.1324N>A | p.Asp442Asn | p.D442N | P40227 | protein_coding | tolerated(0.2) | benign(0.012) | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| CCT6A | SNV | Missense_Mutation | c.1115N>C | p.Val372Ala | p.V372A | P40227 | protein_coding | tolerated(0.07) | possibly_damaging(0.588) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCT6A | SNV | Missense_Mutation | novel | c.867N>A | p.Phe289Leu | p.F289L | P40227 | protein_coding | deleterious(0.04) | possibly_damaging(0.85) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD |
| CCT6A | SNV | Missense_Mutation | novel | c.559N>A | p.Asp187Asn | p.D187N | P40227 | protein_coding | tolerated(0.06) | possibly_damaging(0.558) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| CCT6A | insertion | In_Frame_Ins | novel | c.869_870insCCTAAGATTTAACAG | p.Val290_Val291insLeuArgPheAsnSer | p.V290_V291insLRFNS | P40227 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
| CCT6A | SNV | Missense_Mutation | c.1268N>A | p.Ile423Asn | p.I423N | P40227 | protein_coding | tolerated(0.36) | benign(0.005) | TCGA-A6-6649-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
| CCT6A | SNV | Missense_Mutation | c.464N>A | p.Ser155Tyr | p.S155Y | P40227 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
| CCT6A | SNV | Missense_Mutation | c.650G>A | p.Arg217Gln | p.R217Q | P40227 | protein_coding | deleterious(0.03) | possibly_damaging(0.884) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
| CCT6A | SNV | Missense_Mutation | c.1240N>A | p.Val414Met | p.V414M | P40227 | protein_coding | deleterious(0) | possibly_damaging(0.556) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| CCT6A | SNV | Missense_Mutation | c.1310T>C | p.Val437Ala | p.V437A | P40227 | protein_coding | deleterious(0.03) | benign(0.158) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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