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Gene: CCT4 |
Gene summary for CCT4 |
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Gene information | Species | Human | Gene symbol | CCT4 | Gene ID | 10575 |
Gene name | chaperonin containing TCP1 subunit 4 | |
Gene Alias | CCT-DELTA | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P50991 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10575 | CCT4 | GSM4909285 | Human | Breast | IDC | 1.23e-06 | 3.82e-01 | 0.21 |
10575 | CCT4 | GSM4909286 | Human | Breast | IDC | 6.21e-05 | -2.90e-01 | 0.1081 |
10575 | CCT4 | GSM4909294 | Human | Breast | IDC | 1.28e-05 | -2.48e-01 | 0.2022 |
10575 | CCT4 | GSM4909296 | Human | Breast | IDC | 3.73e-20 | -4.32e-01 | 0.1524 |
10575 | CCT4 | GSM4909297 | Human | Breast | IDC | 4.01e-17 | -2.80e-01 | 0.1517 |
10575 | CCT4 | GSM4909298 | Human | Breast | IDC | 5.16e-05 | -2.45e-01 | 0.1551 |
10575 | CCT4 | GSM4909301 | Human | Breast | IDC | 7.16e-09 | -3.30e-01 | 0.1577 |
10575 | CCT4 | GSM4909302 | Human | Breast | IDC | 1.26e-08 | -4.19e-01 | 0.1545 |
10575 | CCT4 | GSM4909307 | Human | Breast | IDC | 2.51e-07 | -3.41e-01 | 0.1569 |
10575 | CCT4 | GSM4909309 | Human | Breast | IDC | 3.82e-12 | -4.46e-01 | 0.0483 |
10575 | CCT4 | GSM4909311 | Human | Breast | IDC | 1.72e-42 | -4.65e-01 | 0.1534 |
10575 | CCT4 | GSM4909312 | Human | Breast | IDC | 3.04e-18 | -1.80e-01 | 0.1552 |
10575 | CCT4 | GSM4909313 | Human | Breast | IDC | 1.25e-02 | -2.74e-01 | 0.0391 |
10575 | CCT4 | GSM4909319 | Human | Breast | IDC | 7.00e-47 | -5.75e-01 | 0.1563 |
10575 | CCT4 | GSM4909320 | Human | Breast | IDC | 3.00e-03 | -3.57e-01 | 0.1575 |
10575 | CCT4 | GSM4909321 | Human | Breast | IDC | 5.42e-20 | -2.87e-01 | 0.1559 |
10575 | CCT4 | brca1 | Human | Breast | Precancer | 8.78e-05 | 2.84e-01 | -0.0338 |
10575 | CCT4 | NCCBC14 | Human | Breast | DCIS | 4.50e-07 | -1.42e-01 | 0.2021 |
10575 | CCT4 | NCCBC2 | Human | Breast | DCIS | 8.42e-04 | -5.43e-01 | 0.1554 |
10575 | CCT4 | NCCBC3 | Human | Breast | DCIS | 1.18e-02 | -1.32e-01 | 0.1198 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:00508219 | Breast | Precancer | protein stabilization | 29/1080 | 191/18723 | 1.67e-06 | 6.08e-05 | 29 |
GO:00316479 | Breast | Precancer | regulation of protein stability | 38/1080 | 298/18723 | 3.73e-06 | 1.19e-04 | 38 |
GO:00108338 | Breast | Precancer | telomere maintenance via telomere lengthening | 15/1080 | 81/18723 | 5.31e-05 | 1.11e-03 | 15 |
GO:00007238 | Breast | Precancer | telomere maintenance | 20/1080 | 131/18723 | 6.10e-05 | 1.25e-03 | 20 |
GO:19901734 | Breast | Precancer | protein localization to nucleoplasm | 6/1080 | 14/18723 | 7.30e-05 | 1.44e-03 | 6 |
GO:20005738 | Breast | Precancer | positive regulation of DNA biosynthetic process | 13/1080 | 66/18723 | 8.54e-05 | 1.63e-03 | 13 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:19048743 | Breast | Precancer | positive regulation of telomerase RNA localization to Cajal body | 6/1080 | 15/18723 | 1.16e-04 | 2.08e-03 | 6 |
GO:19048516 | Breast | Precancer | positive regulation of establishment of protein localization to telomere | 5/1080 | 10/18723 | 1.25e-04 | 2.21e-03 | 5 |
GO:00070047 | Breast | Precancer | telomere maintenance via telomerase | 13/1080 | 69/18723 | 1.37e-04 | 2.38e-03 | 13 |
GO:19043567 | Breast | Precancer | regulation of telomere maintenance via telomere lengthening | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:19043588 | Breast | Precancer | positive regulation of telomere maintenance via telomere lengthening | 9/1080 | 37/18723 | 1.96e-04 | 3.10e-03 | 9 |
GO:00702034 | Breast | Precancer | regulation of establishment of protein localization to telomere | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:19048694 | Breast | Precancer | regulation of protein localization to Cajal body | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:19048714 | Breast | Precancer | positive regulation of protein localization to Cajal body | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:00062786 | Breast | Precancer | RNA-dependent DNA biosynthetic process | 13/1080 | 75/18723 | 3.27e-04 | 4.64e-03 | 13 |
GO:0035036 | Breast | Precancer | sperm-egg recognition | 10/1080 | 48/18723 | 3.43e-04 | 4.81e-03 | 10 |
GO:00702026 | Breast | Precancer | regulation of establishment of protein localization to chromosome | 5/1080 | 12/18723 | 3.56e-04 | 4.93e-03 | 5 |
GO:19034053 | Breast | Precancer | protein localization to nuclear body | 5/1080 | 12/18723 | 3.56e-04 | 4.93e-03 | 5 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT4 | SNV | Missense_Mutation | rs780164717 | c.1487N>A | p.Arg496Gln | p.R496Q | P50991 | protein_coding | tolerated(0.09) | probably_damaging(0.924) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCT4 | SNV | Missense_Mutation | novel | c.898A>T | p.Ile300Leu | p.I300L | P50991 | protein_coding | tolerated(0.07) | benign(0.034) | TCGA-E2-A576-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
CCT4 | insertion | In_Frame_Ins | novel | c.1072_1073insTAGAGAAAAGCTCATCACCCAGGC | p.Ser358delinsLeuGluLysSerSerSerProArgPro | p.S358delinsLEKSSSPRP | P50991 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
CCT4 | SNV | Missense_Mutation | novel | c.595A>G | p.Thr199Ala | p.T199A | P50991 | protein_coding | tolerated(0.32) | benign(0.021) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CCT4 | SNV | Missense_Mutation | novel | c.1223C>T | p.Ala408Val | p.A408V | P50991 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT4 | SNV | Missense_Mutation | rs140356041 | c.967N>G | p.Met323Val | p.M323V | P50991 | protein_coding | deleterious(0.01) | benign(0.338) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CCT4 | SNV | Missense_Mutation | c.881N>A | p.Gly294Glu | p.G294E | P50991 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5341-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
CCT4 | SNV | Missense_Mutation | rs769218948 | c.1159N>G | p.Thr387Ala | p.T387A | P50991 | protein_coding | deleterious(0.01) | benign(0.071) | TCGA-AG-4001-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT4 | SNV | Missense_Mutation | c.1512G>T | p.Leu504Phe | p.L504F | P50991 | protein_coding | tolerated(0.17) | benign(0.025) | TCGA-AG-4022-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
CCT4 | insertion | Nonsense_Mutation | novel | c.1386_1387insAATTAATCAATATTT | p.Pro462_Ser463insAsnTerSerIlePhe | p.P462_S463insN*SIF | P50991 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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