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Gene: CCT3 |
Gene summary for CCT3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCT3 | Gene ID | 7203 |
| Gene name | chaperonin containing TCP1 subunit 3 | |
| Gene Alias | CCT-gamma | |
| Cytomap | 1q22 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B3KX11 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7203 | CCT3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.31e-06 | 3.23e-01 | 0.0155 |
| 7203 | CCT3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.24e-04 | 4.71e-01 | -0.1808 |
| 7203 | CCT3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.86e-02 | 5.58e-01 | 0.0216 |
| 7203 | CCT3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.74e-17 | 7.87e-01 | -0.0811 |
| 7203 | CCT3 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.45e-08 | 5.31e-01 | -0.1088 |
| 7203 | CCT3 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.63e-20 | 6.57e-01 | -0.1954 |
| 7203 | CCT3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.45e-07 | 7.28e-01 | -0.1207 |
| 7203 | CCT3 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.90e-07 | 4.94e-01 | -0.1526 |
| 7203 | CCT3 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.49e-14 | 6.02e-01 | -0.1464 |
| 7203 | CCT3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.40e-10 | 5.03e-01 | -0.1001 |
| 7203 | CCT3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.57e-29 | 1.25e+00 | -0.059 |
| 7203 | CCT3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.44e-05 | 7.46e-01 | -0.1706 |
| 7203 | CCT3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.37e-03 | 3.79e-01 | -0.2061 |
| 7203 | CCT3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.11e-04 | 6.53e-01 | -0.1462 |
| 7203 | CCT3 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.92e-06 | 5.60e-01 | -0.0842 |
| 7203 | CCT3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.18e-02 | 4.93e-01 | -0.0179 |
| 7203 | CCT3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.93e-29 | 1.10e+00 | 0.096 |
| 7203 | CCT3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.67e-02 | 6.16e-01 | 0.0446 |
| 7203 | CCT3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.81e-04 | 5.50e-01 | 0.0528 |
| 7203 | CCT3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.84e-05 | 6.63e-01 | 0.0131 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
| GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
| GO:0031647 | Colorectum | AD | regulation of protein stability | 108/3918 | 298/18723 | 6.33e-10 | 5.08e-08 | 108 |
| GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
| GO:0050821 | Colorectum | AD | protein stabilization | 73/3918 | 191/18723 | 3.02e-08 | 1.64e-06 | 73 |
| GO:1900180 | Colorectum | AD | regulation of protein localization to nucleus | 55/3918 | 136/18723 | 1.70e-07 | 7.34e-06 | 55 |
| GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
| GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
| GO:1900182 | Colorectum | AD | positive regulation of protein localization to nucleus | 38/3918 | 87/18723 | 1.43e-06 | 4.52e-05 | 38 |
| GO:0006403 | Colorectum | AD | RNA localization | 71/3918 | 201/18723 | 1.54e-06 | 4.76e-05 | 71 |
| GO:0034504 | Colorectum | AD | protein localization to nucleus | 94/3918 | 290/18723 | 2.83e-06 | 8.09e-05 | 94 |
| GO:0006457 | Colorectum | AD | protein folding | 73/3918 | 212/18723 | 3.24e-06 | 9.10e-05 | 73 |
| GO:2001252 | Colorectum | AD | positive regulation of chromosome organization | 35/3918 | 82/18723 | 6.90e-06 | 1.72e-04 | 35 |
| GO:2000278 | Colorectum | AD | regulation of DNA biosynthetic process | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
| GO:2000573 | Colorectum | AD | positive regulation of DNA biosynthetic process | 28/3918 | 66/18723 | 6.35e-05 | 1.05e-03 | 28 |
| GO:0032206 | Colorectum | AD | positive regulation of telomere maintenance | 23/3918 | 52/18723 | 1.31e-04 | 1.88e-03 | 23 |
| GO:0032204 | Colorectum | AD | regulation of telomere maintenance | 31/3918 | 80/18723 | 2.01e-04 | 2.67e-03 | 31 |
| GO:0033044 | Colorectum | AD | regulation of chromosome organization | 60/3918 | 187/18723 | 2.25e-04 | 2.94e-03 | 60 |
| GO:0000723 | Colorectum | AD | telomere maintenance | 43/3918 | 131/18723 | 9.77e-04 | 9.20e-03 | 43 |
| GO:0010833 | Colorectum | AD | telomere maintenance via telomere lengthening | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CCT3 | SNV | Missense_Mutation | novel | c.1345C>A | p.Arg449Ser | p.R449S | P49368 | protein_coding | deleterious(0.04) | possibly_damaging(0.531) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| CCT3 | SNV | Missense_Mutation | rs763340746 | c.1535N>T | p.Thr512Met | p.T512M | P49368 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
| CCT3 | SNV | Missense_Mutation | c.773N>G | p.Ile258Ser | p.I258S | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | |
| CCT3 | SNV | Missense_Mutation | rs746245572 | c.710N>A | p.Arg237His | p.R237H | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-D8-A1XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
| CCT3 | SNV | Missense_Mutation | c.1447G>A | p.Glu483Lys | p.E483K | P49368 | protein_coding | tolerated(0.47) | benign(0.013) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD | |
| CCT3 | insertion | Nonsense_Mutation | novel | c.1227_1228insAAGACCTAACTTTATGGTTAG | p.Pro409_Gly410insLysThrTerLeuTyrGlyTer | p.P409_G410insKT*LYG* | P49368 | protein_coding | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| CCT3 | insertion | Nonsense_Mutation | novel | c.1225_1226insTAGCATAATGGA | p.Pro409delinsLeuAlaTerTrpThr | p.P409delinsLA*WT | P49368 | protein_coding | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| CCT3 | SNV | Missense_Mutation | rs375964353 | c.688C>T | p.Arg230Trp | p.R230W | P49368 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| CCT3 | SNV | Missense_Mutation | rs373870763 | c.1567G>A | p.Val523Ile | p.V523I | P49368 | protein_coding | tolerated(0.29) | possibly_damaging(0.546) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| CCT3 | SNV | Missense_Mutation | novel | c.59G>T | p.Arg20Ile | p.R20I | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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