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Gene: CCR10 |
Gene summary for CCR10 |
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Gene information | Species | Human | Gene symbol | CCR10 | Gene ID | 2826 |
Gene name | C-C motif chemokine receptor 10 | |
Gene Alias | GPR2 | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P46092 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2826 | CCR10 | Pt13.b | Human | Liver | HCC | 6.92e-16 | 3.21e-01 | 0.0251 |
2826 | CCR10 | S014 | Human | Liver | HCC | 1.36e-19 | 5.38e-01 | 0.2254 |
2826 | CCR10 | S015 | Human | Liver | HCC | 1.42e-29 | 9.53e-01 | 0.2375 |
2826 | CCR10 | S016 | Human | Liver | HCC | 7.33e-25 | 6.46e-01 | 0.2243 |
2826 | CCR10 | S029 | Human | Liver | HCC | 2.14e-02 | 1.18e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
CCL28 | CCR10 | CCL28_CCR10 | CCL | Breast | DCIS |
CCL28 | CCR10 | CCL28_CCR10 | CCL | Breast | Healthy |
CCL28 | CCR10 | CCL28_CCR10 | CCL | CRC | AD |
CCL28 | CCR10 | CCL28_CCR10 | CCL | CRC | MSI-H |
CCL28 | CCR10 | CCL28_CCR10 | CCL | CRC | SER |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCR10 | SNV | Missense_Mutation | novel | c.233C>T | p.Ser78Phe | p.S78F | P46092 | protein_coding | deleterious(0.01) | possibly_damaging(0.483) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CCR10 | SNV | Missense_Mutation | novel | c.291N>A | p.Phe97Leu | p.F97L | P46092 | protein_coding | deleterious(0.01) | benign(0.049) | TCGA-VS-A9UP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CCR10 | SNV | Missense_Mutation | novel | c.518N>T | p.Ala173Val | p.A173V | P46092 | protein_coding | deleterious(0.01) | possibly_damaging(0.877) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
CCR10 | SNV | Missense_Mutation | novel | c.1005N>C | p.Gln335His | p.Q335H | P46092 | protein_coding | tolerated(0.44) | benign(0) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD |
CCR10 | SNV | Missense_Mutation | novel | c.451N>T | p.Arg151Trp | p.R151W | P46092 | protein_coding | deleterious(0) | possibly_damaging(0.813) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CCR10 | SNV | Missense_Mutation | c.214N>A | p.Ala72Thr | p.A72T | P46092 | protein_coding | tolerated(0.59) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
CCR10 | SNV | Missense_Mutation | c.299C>T | p.Ala100Val | p.A100V | P46092 | protein_coding | tolerated(0.74) | benign(0.012) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
CCR10 | SNV | Missense_Mutation | novel | c.925N>A | p.Leu309Ile | p.L309I | P46092 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CCR10 | deletion | Frame_Shift_Del | c.1039delT | p.Ser347LeufsTer27 | p.S347Lfs*27 | P46092 | protein_coding | TCGA-DM-A28E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
CCR10 | SNV | Missense_Mutation | c.262G>A | p.Asp88Asn | p.D88N | P46092 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2826 | CCR10 | DRUGGABLE GENOME, CELL SURFACE, G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE | antagonist | 348353673 | ||
2826 | CCR10 | DRUGGABLE GENOME, CELL SURFACE, G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE | agonist | 135651679 | ||
2826 | CCR10 | DRUGGABLE GENOME, CELL SURFACE, G PROTEIN COUPLED RECEPTOR, EXTERNAL SIDE OF PLASMA MEMBRANE | agonist | 135651681 |
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