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Gene: CCNQ |
Gene summary for CCNQ |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CCNQ | Gene ID | 92002 |
| Gene name | cyclin Q | |
| Gene Alias | CycM | |
| Cytomap | Xq28 | |
| Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N1B3 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 92002 | CCNQ | S014 | Human | Liver | HCC | 1.68e-10 | 2.66e-01 | 0.2254 |
| 92002 | CCNQ | S015 | Human | Liver | HCC | 6.11e-04 | 1.42e-01 | 0.2375 |
| 92002 | CCNQ | S016 | Human | Liver | HCC | 2.76e-11 | 2.64e-01 | 0.2243 |
| 92002 | CCNQ | S027 | Human | Liver | HCC | 2.12e-21 | 1.26e+00 | 0.2446 |
| 92002 | CCNQ | S028 | Human | Liver | HCC | 1.55e-39 | 1.45e+00 | 0.2503 |
| 92002 | CCNQ | S029 | Human | Liver | HCC | 8.56e-37 | 1.53e+00 | 0.2581 |
| 92002 | CCNQ | male-WTA | Human | Thyroid | PTC | 1.09e-02 | 8.87e-02 | 0.1037 |
| 92002 | CCNQ | PTC01 | Human | Thyroid | PTC | 2.43e-03 | 1.31e-01 | 0.1899 |
| 92002 | CCNQ | PTC04 | Human | Thyroid | PTC | 1.25e-05 | 1.34e-01 | 0.1927 |
| 92002 | CCNQ | PTC05 | Human | Thyroid | PTC | 3.81e-05 | 1.95e-01 | 0.2065 |
| 92002 | CCNQ | PTC06 | Human | Thyroid | PTC | 1.18e-11 | 2.84e-01 | 0.2057 |
| 92002 | CCNQ | PTC07 | Human | Thyroid | PTC | 2.77e-07 | 2.14e-01 | 0.2044 |
| 92002 | CCNQ | ATC11 | Human | Thyroid | ATC | 3.71e-05 | 3.68e-01 | 0.3386 |
| 92002 | CCNQ | ATC12 | Human | Thyroid | ATC | 2.82e-21 | 4.33e-01 | 0.34 |
| 92002 | CCNQ | ATC13 | Human | Thyroid | ATC | 8.75e-26 | 4.90e-01 | 0.34 |
| 92002 | CCNQ | ATC2 | Human | Thyroid | ATC | 4.44e-15 | 1.02e+00 | 0.34 |
| 92002 | CCNQ | ATC3 | Human | Thyroid | ATC | 6.43e-04 | 2.68e-01 | 0.338 |
| 92002 | CCNQ | ATC4 | Human | Thyroid | ATC | 3.45e-27 | 5.90e-01 | 0.34 |
| 92002 | CCNQ | ATC5 | Human | Thyroid | ATC | 2.95e-31 | 5.39e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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